Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain

The presence of bacteria resistant to antibiotics, such as Staphylococcus aureus resistant to methicillin (MRSA), is becoming an increasing everyday concern for their implications for human and animal health. This is even more alarming when such bacteria are isolated in wild animals which, in princi...

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Autores: Moreno-Grúa, Elena|||0000-0002-9154-5975, Pérez-Fuentes, Sara|||0000-0001-5173-4539, Viana, David|||0000-0002-5813-0356, Cardells-Peris, Jesús|||0000-0003-1401-772X, Lizana, Victor|||0000-0003-2490-6336, Aguiló-Gisbert, Jordi|||0000-0002-2162-9495, Selva, Laura|||0000-0002-7920-1918, Corpa Arenas, Juan Manuel|||0000-0002-2690-3828
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252724
Acceso en línea:https://ddd.uab.cat/record/252724
https://dx.doi.org/urn:doi:10.3390/ani10071109
Access Level:acceso abierto
Palabra clave:Methicillin-resistant Staphylococcus aureus
MRSA
Mec C gene
Wild rabbits
High-density areas
id ES_352b2100549e690e17dc256faba00cc2
oai_identifier_str oai:ddd.uab.cat:252724
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
title Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
spellingShingle Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
Moreno-Grúa, Elena|||0000-0002-9154-5975
Methicillin-resistant Staphylococcus aureus
MRSA
Mec C gene
Wild rabbits
High-density areas
title_short Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
title_full Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
title_fullStr Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
title_full_unstemmed Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
title_sort Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, Spain
dc.creator.none.fl_str_mv Moreno-Grúa, Elena|||0000-0002-9154-5975
Pérez-Fuentes, Sara|||0000-0001-5173-4539
Viana, David|||0000-0002-5813-0356
Cardells-Peris, Jesús|||0000-0003-1401-772X
Lizana, Victor|||0000-0003-2490-6336
Aguiló-Gisbert, Jordi|||0000-0002-2162-9495
Selva, Laura|||0000-0002-7920-1918
Corpa Arenas, Juan Manuel|||0000-0002-2690-3828
author Moreno-Grúa, Elena|||0000-0002-9154-5975
author_facet Moreno-Grúa, Elena|||0000-0002-9154-5975
Pérez-Fuentes, Sara|||0000-0001-5173-4539
Viana, David|||0000-0002-5813-0356
Cardells-Peris, Jesús|||0000-0003-1401-772X
Lizana, Victor|||0000-0003-2490-6336
Aguiló-Gisbert, Jordi|||0000-0002-2162-9495
Selva, Laura|||0000-0002-7920-1918
Corpa Arenas, Juan Manuel|||0000-0002-2690-3828
author_role author
author2 Pérez-Fuentes, Sara|||0000-0001-5173-4539
Viana, David|||0000-0002-5813-0356
Cardells-Peris, Jesús|||0000-0003-1401-772X
Lizana, Victor|||0000-0003-2490-6336
Aguiló-Gisbert, Jordi|||0000-0002-2162-9495
Selva, Laura|||0000-0002-7920-1918
Corpa Arenas, Juan Manuel|||0000-0002-2690-3828
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Methicillin-resistant Staphylococcus aureus
MRSA
Mec C gene
Wild rabbits
High-density areas
topic Methicillin-resistant Staphylococcus aureus
MRSA
Mec C gene
Wild rabbits
High-density areas
description The presence of bacteria resistant to antibiotics, such as Staphylococcus aureus resistant to methicillin (MRSA), is becoming an increasing everyday concern for their implications for human and animal health. This is even more alarming when such bacteria are isolated in wild animals which, in principle, should not come into contact with antibiotics. This work studied 353 rabbits and 10 hares hunted in rabbit high-density areas. Of these, 41.3% carried S. aureus in some sampled locations, of which 63.3% were MRSA. These are surprising results given the unexpected high presence of MRSA in the studied animals. This finding is very worrying because these animals tend to enter the food chain with no veterinary control, which implies a risk for human health. Thus it is necessary to extend this study to other, less-populated areas with other animal species (ruminants, rabbit predators, hunting dogs, etc.) or even water sources to obtain further knowledge about the origin of bacterial resistances in nature. The appearance of methicillin-resistant strains of Staphylococcus aureus (MRSA) in several animal species (including rabbits) has set off alarms for their capacity to act as reservoirs for this bacterium. This is especially important in wild animals given its epidemiological implications. The objectives of this study were to identify and characterize S. aureus, specifically MRSA, strains in wild lagomorph high-density areas. Ten hares and 353 wild rabbits from 14 towns with a high rabbit density in the Valencian region (eastern Spanish coast) were sampled. Swabs from the nasal cavity, ears, perineum and lesions (when present) were taken for microbiological studies. The detection of different genes and antibiotic susceptibility studies were also carried out. Of all the animals, 41.3% were positive for S. aureus, of which 63.3% were MRSA. Ears were the anatomical location with more S. aureus and MRSA strains. The more frequently identified MLST type was ST1945 (97.1%, 136/140). The mec A gene was found only in one sample. The rest (n = 139) carried the mec C gene and were included in CC130, except one. Penicillin resistance was detected in 28 mec -negative isolates and, in one case, bacitracin resistance. mec A isolate presented resistance to enrofloxacin and tetracycline, and 10 mec C isolates also showed bacitracin resistance. No MRSA isolate was positive for genes chp, sea, tst and PVL. Two ST1945 isolates contained IEC type E (comprising genes scn and sak). mec A-isolate was positive for bla Z. Of the 28 MSSA strains showing resistance to penicillin, 22 carried the bla Z gene. These surprising results highlight the marked presence of MRSA strains in wild rabbits in high-density areas.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252724
https://dx.doi.org/urn:doi:10.3390/ani10071109
url https://ddd.uab.cat/record/252724
https://dx.doi.org/urn:doi:10.3390/ani10071109
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU17/02708
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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spelling Marked Presence of Methicillin-Resistant Staphylococcus aureus in Wild Lagomorphs in Valencia, SpainMoreno-Grúa, Elena|||0000-0002-9154-5975Pérez-Fuentes, Sara|||0000-0001-5173-4539Viana, David|||0000-0002-5813-0356Cardells-Peris, Jesús|||0000-0003-1401-772XLizana, Victor|||0000-0003-2490-6336Aguiló-Gisbert, Jordi|||0000-0002-2162-9495Selva, Laura|||0000-0002-7920-1918Corpa Arenas, Juan Manuel|||0000-0002-2690-3828Methicillin-resistant Staphylococcus aureusMRSAMec C geneWild rabbitsHigh-density areasThe presence of bacteria resistant to antibiotics, such as Staphylococcus aureus resistant to methicillin (MRSA), is becoming an increasing everyday concern for their implications for human and animal health. This is even more alarming when such bacteria are isolated in wild animals which, in principle, should not come into contact with antibiotics. This work studied 353 rabbits and 10 hares hunted in rabbit high-density areas. Of these, 41.3% carried S. aureus in some sampled locations, of which 63.3% were MRSA. These are surprising results given the unexpected high presence of MRSA in the studied animals. This finding is very worrying because these animals tend to enter the food chain with no veterinary control, which implies a risk for human health. Thus it is necessary to extend this study to other, less-populated areas with other animal species (ruminants, rabbit predators, hunting dogs, etc.) or even water sources to obtain further knowledge about the origin of bacterial resistances in nature. The appearance of methicillin-resistant strains of Staphylococcus aureus (MRSA) in several animal species (including rabbits) has set off alarms for their capacity to act as reservoirs for this bacterium. This is especially important in wild animals given its epidemiological implications. The objectives of this study were to identify and characterize S. aureus, specifically MRSA, strains in wild lagomorph high-density areas. Ten hares and 353 wild rabbits from 14 towns with a high rabbit density in the Valencian region (eastern Spanish coast) were sampled. Swabs from the nasal cavity, ears, perineum and lesions (when present) were taken for microbiological studies. The detection of different genes and antibiotic susceptibility studies were also carried out. Of all the animals, 41.3% were positive for S. aureus, of which 63.3% were MRSA. Ears were the anatomical location with more S. aureus and MRSA strains. The more frequently identified MLST type was ST1945 (97.1%, 136/140). The mec A gene was found only in one sample. The rest (n = 139) carried the mec C gene and were included in CC130, except one. Penicillin resistance was detected in 28 mec -negative isolates and, in one case, bacitracin resistance. mec A isolate presented resistance to enrofloxacin and tetracycline, and 10 mec C isolates also showed bacitracin resistance. No MRSA isolate was positive for genes chp, sea, tst and PVL. Two ST1945 isolates contained IEC type E (comprising genes scn and sak). mec A-isolate was positive for bla Z. Of the 28 MSSA strains showing resistance to penicillin, 22 carried the bla Z gene. These surprising results highlight the marked presence of MRSA strains in wild rabbits in high-density areas. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252724https://dx.doi.org/urn:doi:10.3390/ani10071109reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU17/02708open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2527242026-06-06T12:50:31Z
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