Role of rs10406069 in miR-5196 in hyperdiploid childhood acute lymphoblastic leukemia

Aim: To determine the role of single nucleotide polymorphisms (SNPs) in noncoding RNAs in childhood acute lymphoblastic leukemia (ALL) subtypes. Materials&methods: We screened all SNPs in 130 pre-miRNA genes to assess their role in the susceptibility of the most common subtypes of ALL: hyperdipl...

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Detalles Bibliográficos
Autores: Gutiérrez Camino, Ángela, Richer, Chantal, St-Onge, Pascal, López López, Elixabet, Carbone Bañeres, Ana, García de Andoin Barandiaran, Nagore, Sastre, Ana, Astigarraga Aguirre, María Iciar, Martín Guerrero, Idoia, Sinnet, Daniel, García-Orad Carles, África
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/77274
Acceso en línea:http://hdl.handle.net/10810/77274
Access Level:acceso abierto
Descripción
Sumario:Aim: To determine the role of single nucleotide polymorphisms (SNPs) in noncoding RNAs in childhood acute lymphoblastic leukemia (ALL) subtypes. Materials&methods: We screened all SNPs in 130 pre-miRNA genes to assess their role in the susceptibility of the most common subtypes of ALL: hyperdiploid and ETV6-RUNX1. Results: In two independent cohorts, we found a significant association between rs10406069 in miR-5196 and the risk of developing hyperdiploid ALL. This observation could be explained by the impact of the SNP on miR-5196 expression and in turn, in its target genes. Indeed, rs10406069 was associated with expression changes in SMC1A, a gene involved in sister chromatin cohesion. Conclusion: rs10406069 in miR-5196 may have a relevant role in hyperdiploid ALL risk.

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