Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID
Headache is a common symptom during SARS-CoV-2 infection and may persist beyond three months. Both tension-type and migraine-like headaches have been described during SARS-CoV-2 infection and after immunization. The main objective was to characterize headache phenotype during SARS-CoV-2 infection an...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:biblosearchi::13b606f1ff8ec5a2d4e7fbc5e2d1d2c4 |
| Acceso en línea: | https://hdl.handle.net/10486/769340 https://dx.doi.org/10.3390/covid6010014 |
| Access Level: | acceso abierto |
| Palabra clave: | migraine COVID-19 post-COVID condition post-COVID-19 persistent headache headache phenotypes vaccination Medicina |
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Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVIDDomínguez Gallego, MartaPanos Basterra, PaulaSomovilla, AlbaGonzález Martínez, AliciaRamos, CarmenLópez Rodríguez, Ana BelénMorales Caballero, ÁlvaroLópez-Guerrero Almansa, AmparoGarcía Cebrián, ManuelaVivancos Mora, José AurelioGago Veiga, Ana BeatrizmigraineCOVID-19post-COVID conditionpost-COVID-19 persistent headacheheadache phenotypesvaccinationMedicinaHeadache is a common symptom during SARS-CoV-2 infection and may persist beyond three months. Both tension-type and migraine-like headaches have been described during SARS-CoV-2 infection and after immunization. The main objective was to characterize headache phenotype during SARS-CoV-2 infection and its relationship with headache recurrence following reinfection and COVID-19 vaccination in a cohort of healthcare professionals. Secondary aims included profiling primary headaches and identifying predictors of post-COVID-19 headache persistence. We included 109 participants (86.2% women, mean age 45.3 ± 2.5 years). During infection, 49.5% met ICHD-3 criteria for tension-type headache and 12.8% for migraine. Headache recurred in 62.5% after reinfection and 59.2% after vaccination. A primary-headache history was present in 77.9% of sampled patients (25.9% migraine, 47.1% tension-type). The COVID-19 headache phenotype typically mirrored patients’ previous headache type during reinfection and post-vaccination. Persistent headache beyond three months from SARS-CoV-2 infection occurred in 22.9% and was associated with fibromyalgia and obesity. These findings suggest that COVID-19-related headache often mirrors the patient’s pre-existing primary headache and tends to recur with the same phenotype following reinfection or vaccinationMDPIDepartamento de MedicinaFacultad de Medicina20262026-01-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/769340https://dx.doi.org/10.3390/covid6010014reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:biblosearchi::13b606f1ff8ec5a2d4e7fbc5e2d1d2c42026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| title |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| spellingShingle |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID Domínguez Gallego, Marta migraine COVID-19 post-COVID condition post-COVID-19 persistent headache headache phenotypes vaccination Medicina |
| title_short |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| title_full |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| title_fullStr |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| title_full_unstemmed |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| title_sort |
Unmasking COVID-19 headaches in healthcare professionals: phenotypic continuity across infection, reinfection, vaccination and Post-COVID |
| dc.creator.none.fl_str_mv |
Domínguez Gallego, Marta Panos Basterra, Paula Somovilla, Alba González Martínez, Alicia Ramos, Carmen López Rodríguez, Ana Belén Morales Caballero, Álvaro López-Guerrero Almansa, Amparo García Cebrián, Manuela Vivancos Mora, José Aurelio Gago Veiga, Ana Beatriz |
| author |
Domínguez Gallego, Marta |
| author_facet |
Domínguez Gallego, Marta Panos Basterra, Paula Somovilla, Alba González Martínez, Alicia Ramos, Carmen López Rodríguez, Ana Belén Morales Caballero, Álvaro López-Guerrero Almansa, Amparo García Cebrián, Manuela Vivancos Mora, José Aurelio Gago Veiga, Ana Beatriz |
| author_role |
author |
| author2 |
Panos Basterra, Paula Somovilla, Alba González Martínez, Alicia Ramos, Carmen López Rodríguez, Ana Belén Morales Caballero, Álvaro López-Guerrero Almansa, Amparo García Cebrián, Manuela Vivancos Mora, José Aurelio Gago Veiga, Ana Beatriz |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
migraine COVID-19 post-COVID condition post-COVID-19 persistent headache headache phenotypes vaccination Medicina |
| topic |
migraine COVID-19 post-COVID condition post-COVID-19 persistent headache headache phenotypes vaccination Medicina |
| description |
Headache is a common symptom during SARS-CoV-2 infection and may persist beyond three months. Both tension-type and migraine-like headaches have been described during SARS-CoV-2 infection and after immunization. The main objective was to characterize headache phenotype during SARS-CoV-2 infection and its relationship with headache recurrence following reinfection and COVID-19 vaccination in a cohort of healthcare professionals. Secondary aims included profiling primary headaches and identifying predictors of post-COVID-19 headache persistence. We included 109 participants (86.2% women, mean age 45.3 ± 2.5 years). During infection, 49.5% met ICHD-3 criteria for tension-type headache and 12.8% for migraine. Headache recurred in 62.5% after reinfection and 59.2% after vaccination. A primary-headache history was present in 77.9% of sampled patients (25.9% migraine, 47.1% tension-type). The COVID-19 headache phenotype typically mirrored patients’ previous headache type during reinfection and post-vaccination. Persistent headache beyond three months from SARS-CoV-2 infection occurred in 22.9% and was associated with fibromyalgia and obesity. These findings suggest that COVID-19-related headache often mirrors the patient’s pre-existing primary headache and tends to recur with the same phenotype following reinfection or vaccination |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 2026-01-06 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10486/769340 https://dx.doi.org/10.3390/covid6010014 |
| url |
https://hdl.handle.net/10486/769340 https://dx.doi.org/10.3390/covid6010014 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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