Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension

Despite the broad pharmacological arsenal to treat hypertension, chronic patients may develop irreversible cardiac remodeling and fibrosis. Angiotensin II, the main peptide responsible for the Renin-Angiotensin-Aldosterone-System, has been closely linked to cardiac remodeling, hypertrophy, fibrosis,...

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Autores: Olivares Silva, Francisco, De Gregorio, Nicole, Espitia Corredor, Jenaro Antonio, Espinoza, Claudio, Vivar, Raúl, Silva, David, Osorio, José Miguel, Lavandero, Sergio, Peiró Vallejo, M. Concepción, Sánchez Ferrer, Carlos Félix, Díaz-Araya, Guillermo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/710518
Acceso en línea:http://hdl.handle.net/10486/710518
https://dx.doi.org/10.1016/j.bbadis.2021.166241
Access Level:acceso abierto
Palabra clave:resolvin-D1
angiotensin II
cardiac remodeling
hypertension
inflammation
Medicina
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spelling Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertensionOlivares Silva, FranciscoDe Gregorio, NicoleEspitia Corredor, Jenaro AntonioEspinoza, ClaudioVivar, RaúlSilva, DavidOsorio, José MiguelLavandero, SergioPeiró Vallejo, M. ConcepciónSánchez Ferrer, Carlos FélixDíaz-Araya, Guillermoresolvin-D1angiotensin IIcardiac remodelinghypertensioninflammationMedicinaDespite the broad pharmacological arsenal to treat hypertension, chronic patients may develop irreversible cardiac remodeling and fibrosis. Angiotensin II, the main peptide responsible for the Renin-Angiotensin-Aldosterone-System, has been closely linked to cardiac remodeling, hypertrophy, fibrosis, and hypertension, and some of these effects are induced by inflammatory mediators. Resolvin-D1 (RvD1) elicits potent anti-inflammatory and pro-resolving effects in various pathological models. In this study, we aimed to examine whether RvD1 ameliorates cardiac remodeling and hypertension triggered by angiotensin II. Methods and results Alzet® osmotic mini-pumps filled with angiotensin II (1.5 mg/kg/day) were implanted in male C57BL/6 J mice for 7 or 14 days. RvD1 (3 μg/kg/day, i.p) was administered one day after the surgery and during the complete infusion period. Blood pressure and myocardial functional parameters were assessed by echocardiography. At the end of the experimental procedure, blood and heart tissue were harvested, and plasma and histological parameters were studied. After 7 and 14 days, RvD1 reduced the increase of neutrophil and macrophage infiltration triggered by angiotensin II, and also reduced ICAM-1 and VCAM-1 expression levels. RvD1 also reduced cytokine plasma levels (IL-1β, TNF-α, IL-6, KC, MCP-1), cardiac hypertrophy, interstitial and perivascular fibrosis, and hypertension. Conclusions This study unveils novel cardioprotective effects of RvD1 in angiotensin II-induced hypertension and cardiac remodeling by attenuating inflammation and provides insights into a potential clinical applicationElsevierDepartamento de FarmacologíaFacultad de Medicina20212021-08-13research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/710518https://dx.doi.org/10.1016/j.bbadis.2021.166241reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7105182026-06-23T12:46:27Z
dc.title.none.fl_str_mv Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
title Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
spellingShingle Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
Olivares Silva, Francisco
resolvin-D1
angiotensin II
cardiac remodeling
hypertension
inflammation
Medicina
title_short Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
title_full Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
title_fullStr Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
title_full_unstemmed Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
title_sort Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension
dc.creator.none.fl_str_mv Olivares Silva, Francisco
De Gregorio, Nicole
Espitia Corredor, Jenaro Antonio
Espinoza, Claudio
Vivar, Raúl
Silva, David
Osorio, José Miguel
Lavandero, Sergio
Peiró Vallejo, M. Concepción
Sánchez Ferrer, Carlos Félix
Díaz-Araya, Guillermo
author Olivares Silva, Francisco
author_facet Olivares Silva, Francisco
De Gregorio, Nicole
Espitia Corredor, Jenaro Antonio
Espinoza, Claudio
Vivar, Raúl
Silva, David
Osorio, José Miguel
Lavandero, Sergio
Peiró Vallejo, M. Concepción
Sánchez Ferrer, Carlos Félix
Díaz-Araya, Guillermo
author_role author
author2 De Gregorio, Nicole
Espitia Corredor, Jenaro Antonio
Espinoza, Claudio
Vivar, Raúl
Silva, David
Osorio, José Miguel
Lavandero, Sergio
Peiró Vallejo, M. Concepción
Sánchez Ferrer, Carlos Félix
Díaz-Araya, Guillermo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Farmacología
Facultad de Medicina
dc.subject.none.fl_str_mv resolvin-D1
angiotensin II
cardiac remodeling
hypertension
inflammation
Medicina
topic resolvin-D1
angiotensin II
cardiac remodeling
hypertension
inflammation
Medicina
description Despite the broad pharmacological arsenal to treat hypertension, chronic patients may develop irreversible cardiac remodeling and fibrosis. Angiotensin II, the main peptide responsible for the Renin-Angiotensin-Aldosterone-System, has been closely linked to cardiac remodeling, hypertrophy, fibrosis, and hypertension, and some of these effects are induced by inflammatory mediators. Resolvin-D1 (RvD1) elicits potent anti-inflammatory and pro-resolving effects in various pathological models. In this study, we aimed to examine whether RvD1 ameliorates cardiac remodeling and hypertension triggered by angiotensin II. Methods and results Alzet® osmotic mini-pumps filled with angiotensin II (1.5 mg/kg/day) were implanted in male C57BL/6 J mice for 7 or 14 days. RvD1 (3 μg/kg/day, i.p) was administered one day after the surgery and during the complete infusion period. Blood pressure and myocardial functional parameters were assessed by echocardiography. At the end of the experimental procedure, blood and heart tissue were harvested, and plasma and histological parameters were studied. After 7 and 14 days, RvD1 reduced the increase of neutrophil and macrophage infiltration triggered by angiotensin II, and also reduced ICAM-1 and VCAM-1 expression levels. RvD1 also reduced cytokine plasma levels (IL-1β, TNF-α, IL-6, KC, MCP-1), cardiac hypertrophy, interstitial and perivascular fibrosis, and hypertension. Conclusions This study unveils novel cardioprotective effects of RvD1 in angiotensin II-induced hypertension and cardiac remodeling by attenuating inflammation and provides insights into a potential clinical application
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-08-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/710518
https://dx.doi.org/10.1016/j.bbadis.2021.166241
url http://hdl.handle.net/10486/710518
https://dx.doi.org/10.1016/j.bbadis.2021.166241
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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