Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach

This article belongs to the Special Issue Natural Compounds for Disease and Health, 3rd Edition

Detalles Bibliográficos
Autores: Majchrzak, Marta, Paterson, Samuel, Gómez-Cortés, Pilar, Silván, José Manuel, Martínez-Rodríguez, Adolfo J., Hernández-Ledesma, Blanca
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412221
Acceso en línea:http://hdl.handle.net/10261/412221
Access Level:acceso abierto
Palabra clave:Microalgae
Tetraselmis chuii
Bioactive peptides
In silico digestion
Helicobacter pylori
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spelling Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity ApproachMajchrzak, MartaPaterson, SamuelGómez-Cortés, PilarSilván, José ManuelMartínez-Rodríguez, Adolfo J.Hernández-Ledesma, BlancaMicroalgaeTetraselmis chuiiBioactive peptidesIn silico digestionHelicobacter pyloriThis article belongs to the Special Issue Natural Compounds for Disease and Health, 3rd EditionMicroalgae represent sustainable sources of bioactive compounds with potential health benefits. This study conducted a comprehensive proteomic analysis of Tetraselmis chuii (T. chuii) biomass to identify proteins capable of generating bioactive peptides (BAPs) through simulated orogastric digestion. In silico digestion and bioinformatic predictions indicated the release of antioxidant, anti-inflammatory, and antibacterial peptides. Molecular docking demonstrated strong interactions with targets implicated in oxidative stress, inflammation, and Helicobacter pylori (H. pylori) virulence. Biochemical assays and cell-based models confirmed antioxidant and anti-inflammatory activities in both the biomass and its digest, although no significant antibacterial effect against H. pylori was observed under the tested conditions. Considering the role of chronic inflammation in H. pylori-associated pathologies, these findings suggest that T. chuii may serve as a candidate for mitigating tissue damage driven by oxidative and inflammatory stress. Further research is required to address compound stability and optimize delivery strategies.This work was supported through Project PID2021-122989OB-I00, financed by MICIU/AEI/10.13039/501100011033 and FEDER, EU, Project ILINK24023 financed by the Spanish National Research Council (CSIC. Authors (M.M., S.P., P.G.-C., J.M.S., A.J.M.-R. and B.H.-L.) are members of the INNOPROT network funded by CYTED (ref. 124RT0164). S.P. gratefully acknowledges the CM (PIPF-2022/BIO-24996) for his research contract.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Programa Iberoamericano de Ciencia y Tecnología para el DesarrolloComunidad de MadridPaterson, Samuel [0000-0001-6845-7814]Gómez-Cortés, Pilar [0000-0002-2422-5744]Silván, José Manuel [0000-0001-8266-3761]Martínez-Rodríguez, Adolfo J. [0000-0002-6140-0732]Hernández-Ledesma, Blanca [0000-0001-7192-6044]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620252026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/412221reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00PIPF-2022/BIO-24996/The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/molecules30244669https://doi.org/10.3390/molecules30244669Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4122212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
title Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
spellingShingle Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
Majchrzak, Marta
Microalgae
Tetraselmis chuii
Bioactive peptides
In silico digestion
Helicobacter pylori
title_short Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
title_full Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
title_fullStr Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
title_full_unstemmed Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
title_sort Tetraselmis chuii as Source of Bioactive Compounds Against Helicobacter pylori: An Integrated Proteomic and Bioactivity Approach
dc.creator.none.fl_str_mv Majchrzak, Marta
Paterson, Samuel
Gómez-Cortés, Pilar
Silván, José Manuel
Martínez-Rodríguez, Adolfo J.
Hernández-Ledesma, Blanca
author Majchrzak, Marta
author_facet Majchrzak, Marta
Paterson, Samuel
Gómez-Cortés, Pilar
Silván, José Manuel
Martínez-Rodríguez, Adolfo J.
Hernández-Ledesma, Blanca
author_role author
author2 Paterson, Samuel
Gómez-Cortés, Pilar
Silván, José Manuel
Martínez-Rodríguez, Adolfo J.
Hernández-Ledesma, Blanca
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo
Comunidad de Madrid
Paterson, Samuel [0000-0001-6845-7814]
Gómez-Cortés, Pilar [0000-0002-2422-5744]
Silván, José Manuel [0000-0001-8266-3761]
Martínez-Rodríguez, Adolfo J. [0000-0002-6140-0732]
Hernández-Ledesma, Blanca [0000-0001-7192-6044]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Microalgae
Tetraselmis chuii
Bioactive peptides
In silico digestion
Helicobacter pylori
topic Microalgae
Tetraselmis chuii
Bioactive peptides
In silico digestion
Helicobacter pylori
description This article belongs to the Special Issue Natural Compounds for Disease and Health, 3rd Edition
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/412221
url http://hdl.handle.net/10261/412221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122989OB-I00
PIPF-2022/BIO-24996/
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/molecules30244669
https://doi.org/10.3390/molecules30244669
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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