Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS)...

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Autores: Calvo Enrique, Laura, Lisa, Silvia, Vicente-García, Cristina, Deogracias, Ruben, Arévalo Martín, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154976
Acceso en línea:http://hdl.handle.net/10366/154976
Access Level:acceso abierto
Palabra clave:NGF (nerve growth factor)
TrkA
basal forebrain
cholinergic neurons
learning
mice behavior
Receptor, trkA
Cholinergic Neurons
Behavior
2490 Neurociencias
2407 Biología Celular
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oai_identifier_str oai:gredos.usal.es:10366/154976
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repository_id_str
spelling Enhanced TrkA signaling impairs basal forebrain-dependent behaviorCalvo Enrique, LauraLisa, SilviaVicente-García, CristinaDeogracias, RubenArévalo Martín, Juan CarlosNGF (nerve growth factor)TrkAbasal forebraincholinergic neuronslearningmice behaviorReceptor, trkACholinergic NeuronsBehavior2490 Neurociencias2407 Biología CelularBasal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS) have shown contradictory results. To shed light into this discrepancy, we used a mouse model with a gain-of-function in TrkA receptor signaling. Our results indicate that enhanced TrkA signaling did not alter hippocampal cholinergic innervation, general locomotion or anxiety-related behaviors, but it increases ChAT expression, the number of cholinergic neurons at early postnatal stages and, mutant mice showed impaired motor learning and memory functions. These data demonstrate that proper functioning of the cholinergic system in CNS requires a balanced NGF/TrkA signaling.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by MINECO and MCIN grants (BFU2014-51846-R, BFU2017-82667-R, and PID2020-113130RB-100) and by the EU 7th Framework Program (PAINCAGE) to JCA. LC-E was funded with a postdoctoral contract from Junta Castilla y León (SA0252P20) and from H2020-MSCA-COFUND-2020 (USAL4EXCELLENCE-PROOPI-402) and a Ramón and Cajal grant (RYC2021-034520-I).202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154976reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1549762026-06-07T06:28:51Z
dc.title.none.fl_str_mv Enhanced TrkA signaling impairs basal forebrain-dependent behavior
title Enhanced TrkA signaling impairs basal forebrain-dependent behavior
spellingShingle Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Calvo Enrique, Laura
NGF (nerve growth factor)
TrkA
basal forebrain
cholinergic neurons
learning
mice behavior
Receptor, trkA
Cholinergic Neurons
Behavior
2490 Neurociencias
2407 Biología Celular
title_short Enhanced TrkA signaling impairs basal forebrain-dependent behavior
title_full Enhanced TrkA signaling impairs basal forebrain-dependent behavior
title_fullStr Enhanced TrkA signaling impairs basal forebrain-dependent behavior
title_full_unstemmed Enhanced TrkA signaling impairs basal forebrain-dependent behavior
title_sort Enhanced TrkA signaling impairs basal forebrain-dependent behavior
dc.creator.none.fl_str_mv Calvo Enrique, Laura
Lisa, Silvia
Vicente-García, Cristina
Deogracias, Ruben
Arévalo Martín, Juan Carlos
author Calvo Enrique, Laura
author_facet Calvo Enrique, Laura
Lisa, Silvia
Vicente-García, Cristina
Deogracias, Ruben
Arévalo Martín, Juan Carlos
author_role author
author2 Lisa, Silvia
Vicente-García, Cristina
Deogracias, Ruben
Arévalo Martín, Juan Carlos
author2_role author
author
author
author
dc.subject.none.fl_str_mv NGF (nerve growth factor)
TrkA
basal forebrain
cholinergic neurons
learning
mice behavior
Receptor, trkA
Cholinergic Neurons
Behavior
2490 Neurociencias
2407 Biología Celular
topic NGF (nerve growth factor)
TrkA
basal forebrain
cholinergic neurons
learning
mice behavior
Receptor, trkA
Cholinergic Neurons
Behavior
2490 Neurociencias
2407 Biología Celular
description Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS) have shown contradictory results. To shed light into this discrepancy, we used a mouse model with a gain-of-function in TrkA receptor signaling. Our results indicate that enhanced TrkA signaling did not alter hippocampal cholinergic innervation, general locomotion or anxiety-related behaviors, but it increases ChAT expression, the number of cholinergic neurons at early postnatal stages and, mutant mice showed impaired motor learning and memory functions. These data demonstrate that proper functioning of the cholinergic system in CNS requires a balanced NGF/TrkA signaling.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154976
url http://hdl.handle.net/10366/154976
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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