Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study

Background: iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. Methods: we evaluated ID in patients with CHF at 3 university hospita...

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Autores: González-Costello, José, Comín Colet, Josep, Lupón, Josep, Enjuanes, Cristina, Antonio, Marta de, Fuentes, Lara, Moliner, Pedro, Farré, Núria, Zamora, Elisabet, Manito Lorite, Nicolás, Pujol Farriols, Ramon, Bayés Genís, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172149
Acceso en línea:https://hdl.handle.net/2445/172149
Access Level:acceso abierto
Palabra clave:Anèmia
Insuficiència cardíaca
Mortalitat
Pacients
Anemia
Heart failure
Mortality
Patients
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spelling Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort studyGonzález-Costello, JoséComín Colet, JosepLupón, JosepEnjuanes, CristinaAntonio, Marta deFuentes, LaraMoliner, PedroFarré, NúriaZamora, ElisabetManito Lorite, NicolásPujol Farriols, RamonBayés Genís, AntoniAnèmiaInsuficiència cardíacaMortalitatPacientsAnemiaHeart failureMortalityPatientsBackground: iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. Methods: we evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up. We evaluated if ID was a predictor of death or hospitalization due to heart failure or any cause using univariate and multivariate cox regression analysis. Results: we included 1684 patients, 65% males, 38% diabetics, median age of 72 years, 37% in functional class III-IV and 30% of patients with a left ventricular ejection fraction > 45%. Patients were well treated, with 87% and 88% of patients receiving renin-angiotensin inhibitors and beta-blockers, respectively. Median transferrin saturation index was 20%, median ferritin 155 ng/mL and median haemoglobin 13 g/dL. ID was present in 53% of patients; in 35% it was absolute and in 18% functional. Median follow-up was 20 months. ID was a predictor of death, hospitalization due to heart failure or to any cause in univariate analysis but not after multivariate analysis. No differences were found between absolute or functional ID regarding prognosis. Conclusion: in a real life population of patients with CHF and a high prevalence of heart failure with preserved ejection fraction, ID did not predict mortality or hospitalizations after adjustment for comorbidities, functional class and neurohormonal treatment.BioMed Central2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/172149Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s12872-018-0942-xBMC Cardiovascular Disorders, 2018, vol. 18, num. 1, p. 206https://doi.org/10.1186/s12872-018-0942-xcc-by (c) González-Costello, José et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1721492026-05-27T06:46:51Z
dc.title.none.fl_str_mv Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
spellingShingle Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
González-Costello, José
Anèmia
Insuficiència cardíaca
Mortalitat
Pacients
Anemia
Heart failure
Mortality
Patients
title_short Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_full Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_fullStr Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_full_unstemmed Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
title_sort Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study
dc.creator.none.fl_str_mv González-Costello, José
Comín Colet, Josep
Lupón, Josep
Enjuanes, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner, Pedro
Farré, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Farriols, Ramon
Bayés Genís, Antoni
author González-Costello, José
author_facet González-Costello, José
Comín Colet, Josep
Lupón, Josep
Enjuanes, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner, Pedro
Farré, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Farriols, Ramon
Bayés Genís, Antoni
author_role author
author2 Comín Colet, Josep
Lupón, Josep
Enjuanes, Cristina
Antonio, Marta de
Fuentes, Lara
Moliner, Pedro
Farré, Núria
Zamora, Elisabet
Manito Lorite, Nicolás
Pujol Farriols, Ramon
Bayés Genís, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anèmia
Insuficiència cardíaca
Mortalitat
Pacients
Anemia
Heart failure
Mortality
Patients
topic Anèmia
Insuficiència cardíaca
Mortalitat
Pacients
Anemia
Heart failure
Mortality
Patients
description Background: iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. Methods: we evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up. We evaluated if ID was a predictor of death or hospitalization due to heart failure or any cause using univariate and multivariate cox regression analysis. Results: we included 1684 patients, 65% males, 38% diabetics, median age of 72 years, 37% in functional class III-IV and 30% of patients with a left ventricular ejection fraction > 45%. Patients were well treated, with 87% and 88% of patients receiving renin-angiotensin inhibitors and beta-blockers, respectively. Median transferrin saturation index was 20%, median ferritin 155 ng/mL and median haemoglobin 13 g/dL. ID was present in 53% of patients; in 35% it was absolute and in 18% functional. Median follow-up was 20 months. ID was a predictor of death, hospitalization due to heart failure or to any cause in univariate analysis but not after multivariate analysis. No differences were found between absolute or functional ID regarding prognosis. Conclusion: in a real life population of patients with CHF and a high prevalence of heart failure with preserved ejection fraction, ID did not predict mortality or hospitalizations after adjustment for comorbidities, functional class and neurohormonal treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172149
url https://hdl.handle.net/2445/172149
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12872-018-0942-x
BMC Cardiovascular Disorders, 2018, vol. 18, num. 1, p. 206
https://doi.org/10.1186/s12872-018-0942-x
dc.rights.none.fl_str_mv cc-by (c) González-Costello, José et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) González-Costello, José et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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