Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for...

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Detalles Bibliográficos
Autores: Verweij, Paul E, Arendrup, Maiken Cavling, Alastruey-Izquierdo, Ana, Gold, Jeremy A W, Lockhart, Shawn R, Chiller, Tom, White, P Lewis
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/16006
Acceso en línea:http://hdl.handle.net/20.500.12105/16006
Access Level:acceso abierto
Palabra clave:Antifungal Agents
Fungicides, Industrial
Humans
Drug Resistance, Fungal
Azoles
Aspergillus fumigatus
Agriculture
Microbial Sensitivity Tests
Descripción
Sumario:Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.