Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort

[EN] Background. A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle...

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Detalles Bibliográficos
Autores: Ronaldson, Amy, Arias de la Torre, Jorge, Gaughran, Fiona, Bakolis, Ioannis, Hatch, Stephani L., Hotopf, Matthew, Dregan, Alexandru
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Ajuntament de Barcelona
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/27722
Acceso en línea:https://www.cambridge.org/core/journals/psychological-medicine/article/prospective-associations-between-vitamin-d-and-depression-in-middleaged-adults-findings-from-the-uk-biobank-cohort/741D760DB6639901E43FFE2E324DDB8C
https://hdl.handle.net/10612/27722
Access Level:acceso abierto
Palabra clave:Medicina. Salud
Depression
Middle-age
PHQ-9
Vitamin D
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spelling Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohortRonaldson, AmyArias de la Torre, JorgeGaughran, FionaBakolis, IoannisHatch, Stephani L.Hotopf, MatthewDregan, AlexandruMedicina. SaludDepressionMiddle-agePHQ-9Vitamin D[EN] Background. A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank. Methods. We assessed prospective associations between vitamin D status at the baseline assessment (2006–2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank. Results. Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07–1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13–1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00–1.23; deficiency: aOR = 1.30, 95% CI 1.13–1.50). Conclusions. The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health.SIGuy’s CharityMedical Research CouncilNational Institute for Health Research’siomedical Research Centre at South LondonMaudsley NHS Foundation TrustKing’s College LondonStanley Medical Research Institute,Maudsley CharityCambridge University PressMedicina PreventivaFacultad de Veterinaria2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.cambridge.org/core/journals/psychological-medicine/article/prospective-associations-between-vitamin-d-and-depression-in-middleaged-adults-findings-from-the-uk-biobank-cohort/741D760DB6639901E43FFE2E324DDB8Chttps://hdl.handle.net/10612/27722reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Ajuntament de BarcelonaIngléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/277222026-06-24T12:43:27Z
dc.title.none.fl_str_mv Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
title Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
spellingShingle Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
Ronaldson, Amy
Medicina. Salud
Depression
Middle-age
PHQ-9
Vitamin D
title_short Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
title_full Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
title_fullStr Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
title_full_unstemmed Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
title_sort Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort
dc.creator.none.fl_str_mv Ronaldson, Amy
Arias de la Torre, Jorge
Gaughran, Fiona
Bakolis, Ioannis
Hatch, Stephani L.
Hotopf, Matthew
Dregan, Alexandru
author Ronaldson, Amy
author_facet Ronaldson, Amy
Arias de la Torre, Jorge
Gaughran, Fiona
Bakolis, Ioannis
Hatch, Stephani L.
Hotopf, Matthew
Dregan, Alexandru
author_role author
author2 Arias de la Torre, Jorge
Gaughran, Fiona
Bakolis, Ioannis
Hatch, Stephani L.
Hotopf, Matthew
Dregan, Alexandru
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina Preventiva
Facultad de Veterinaria
dc.subject.none.fl_str_mv Medicina. Salud
Depression
Middle-age
PHQ-9
Vitamin D
topic Medicina. Salud
Depression
Middle-age
PHQ-9
Vitamin D
description [EN] Background. A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank. Methods. We assessed prospective associations between vitamin D status at the baseline assessment (2006–2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank. Results. Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07–1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13–1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00–1.23; deficiency: aOR = 1.30, 95% CI 1.13–1.50). Conclusions. The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.cambridge.org/core/journals/psychological-medicine/article/prospective-associations-between-vitamin-d-and-depression-in-middleaged-adults-findings-from-the-uk-biobank-cohort/741D760DB6639901E43FFE2E324DDB8C
https://hdl.handle.net/10612/27722
url https://www.cambridge.org/core/journals/psychological-medicine/article/prospective-associations-between-vitamin-d-and-depression-in-middleaged-adults-findings-from-the-uk-biobank-cohort/741D760DB6639901E43FFE2E324DDB8C
https://hdl.handle.net/10612/27722
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Ajuntament de Barcelona
instname_str Ajuntament de Barcelona
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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