Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients

Article disponible en castellà: http://hdl.handle.net/10230/60098

Detalles Bibliográficos
Autores: Franco, Antonio, Hernández, Domingo, Zarraga, Sofia, Sánchez Fructuoso, Ana, Crespo Barrio, Marta, Mazuecos, Auxiliadora, Díaz-Corte, Carmen, Rodríguez Benot, Alberto, Ruiz, Juan Carlos, Beneyto, Maria Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60097
Acceso en línea:http://hdl.handle.net/10230/60097
http://dx.doi.org/10.1016/j.nefroe.2023.09.001
Access Level:acceso abierto
Palabra clave:Renal transplant recipient
Post-transplant
Lymphoproliferative disorders
Epstein-Barr virus
id ES_34e2698d2af2c78d5b1bb6720f33bbd4
oai_identifier_str oai:repositori.upf.edu:10230/60097
network_acronym_str ES
network_name_str España
repository_id_str
spelling Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipientsFranco, AntonioHernández, DomingoZarraga, SofiaSánchez Fructuoso, AnaCrespo Barrio, MartaMazuecos, AuxiliadoraDíaz-Corte, CarmenRodríguez Benot, AlbertoRuiz, Juan CarlosBeneyto, Maria IsabelRenal transplant recipientPost-transplantLymphoproliferative disordersEpstein-Barr virusArticle disponible en castellà: http://hdl.handle.net/10230/60098Introduction: Post transplant lymphoproliferative disorders (PTLD) are heterogeneous lymphoid proliferations in recipients of solid organs which seem to be related to Epstein Barr Virus (EBV). The use of antilymphocyte antibodies, EBV seronegativity in the recipient,acute rejection and CMV infection have been identified as classical risk factors. Material y methods: We have studied in a retrospective observational study, the incidence of PTLD in a period of 22 years, its relationship with EBV, presence of classical risk factors and outcome in 21546 simple adult renal transplant recipients from cadaveric and living donors, transplanted in 21 hospitals from 1990 to 2009. Results: A total of 275 recipients developed PTLD (1,2%),195 males (70,9%), 80 females (29,1%) aged 59.2 (p25 44.7 p75 68)years. Two hundred forty-five (89.0%) were 1st transplant recipients and 269 (97,8%) from cadaveric donors. EBV in the tissue was reported in 94 out of the 155 studied recipients (60.6%) and 86.0% of the proliferations were due to B lymphocytes. PTLD median appearance after transplant were 42.months (p25, 75, 12, 77, 5). One hundred eighty-eight recipients out of 275 patients (68.3%) had any classical risk factor and the use of antilymphocyte antibodies was the most frequent. During the follow-up, 172 patients died (62,5%) and 103 (37,5%) had a complete remission. The main cause of death was PTLD progression (n = 91, 52,9%), followed by sepsis (n = 24, 13,9%). The follow-up period post-transplant of the recipients was between 3 and 22 years. The incidence was 0,14% during the first year post-trasplant and 0.98% the cumulative incidence at 10 years. Patient survival after diagnosis was 51%, 44% and 39% after 1, 2 and 5 years, respectively. Finally, overall graft survival was 48%, 39% and 33% at the same periods. Conclusion: PTLD has a low incidence in renal transplant recipients. Most of the proliferations are due to B lymphocytes and seem to have a close relationship with EBV. PTLD can develop in the absence of classical risk factors. The prognosis is poor, mainly due to PTLD progression, but the survivors can even maintain their grafts.Elsevier202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60097http://dx.doi.org/10.1016/j.nefroe.2023.09.001reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNefrologia (Engl Ed). 2023 Jul-Aug;43(4):427-34© 2022 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/600972026-06-12T07:21:37Z
dc.title.none.fl_str_mv Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
title Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
spellingShingle Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
Franco, Antonio
Renal transplant recipient
Post-transplant
Lymphoproliferative disorders
Epstein-Barr virus
title_short Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
title_full Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
title_fullStr Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
title_full_unstemmed Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
title_sort Lymphoproliferative disorders after renal transplantation along 2 decades: a large longitudinal study of 21.546 recipients
dc.creator.none.fl_str_mv Franco, Antonio
Hernández, Domingo
Zarraga, Sofia
Sánchez Fructuoso, Ana
Crespo Barrio, Marta
Mazuecos, Auxiliadora
Díaz-Corte, Carmen
Rodríguez Benot, Alberto
Ruiz, Juan Carlos
Beneyto, Maria Isabel
author Franco, Antonio
author_facet Franco, Antonio
Hernández, Domingo
Zarraga, Sofia
Sánchez Fructuoso, Ana
Crespo Barrio, Marta
Mazuecos, Auxiliadora
Díaz-Corte, Carmen
Rodríguez Benot, Alberto
Ruiz, Juan Carlos
Beneyto, Maria Isabel
author_role author
author2 Hernández, Domingo
Zarraga, Sofia
Sánchez Fructuoso, Ana
Crespo Barrio, Marta
Mazuecos, Auxiliadora
Díaz-Corte, Carmen
Rodríguez Benot, Alberto
Ruiz, Juan Carlos
Beneyto, Maria Isabel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Renal transplant recipient
Post-transplant
Lymphoproliferative disorders
Epstein-Barr virus
topic Renal transplant recipient
Post-transplant
Lymphoproliferative disorders
Epstein-Barr virus
description Article disponible en castellà: http://hdl.handle.net/10230/60098
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60097
http://dx.doi.org/10.1016/j.nefroe.2023.09.001
url http://hdl.handle.net/10230/60097
http://dx.doi.org/10.1016/j.nefroe.2023.09.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nefrologia (Engl Ed). 2023 Jul-Aug;43(4):427-34
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405845840723968
score 15,812455

Similares en LA Referencia