Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease

Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are pathologies related to ectopic fat accumulation, both of which are continuously increasing in prevalence. These threats are prompting researchers to develop effective therapies for their clinical management. One of the common pathophy...

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Detalles Bibliográficos
Autores: Infante-Menéndez, Jorge, González-López, Paula, Huertas-Lárez, Raquel, Gómez Hernández, María De La Almudena, Escribano Illanes, Óscar
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/105196
Acceso en línea:https://hdl.handle.net/20.500.14352/105196
Access Level:acceso abierto
Palabra clave:577.1
612.015
Oxidative stress
atherosclerosis
NAFLD
ncRNAs
miRNAs
lncRNAs
circRNAs
RNA-based therapies
Ciencias Biomédicas
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
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oai_identifier_str oai:docta.ucm.es:20.500.14352/105196
network_acronym_str ES
network_name_str España
repository_id_str
spelling Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver DiseaseInfante-Menéndez, JorgeGonzález-López, PaulaHuertas-Lárez, RaquelGómez Hernández, María De La AlmudenaEscribano Illanes, Óscar577.1612.015Oxidative stressatherosclerosisNAFLDncRNAsmiRNAslncRNAscircRNAsRNA-based therapiesCiencias BiomédicasBiología molecular (Farmacia)Bioquímica (Farmacia)32 Ciencias MédicasAtherosclerosis and non-alcoholic fatty liver disease (NAFLD) are pathologies related to ectopic fat accumulation, both of which are continuously increasing in prevalence. These threats are prompting researchers to develop effective therapies for their clinical management. One of the common pathophysiological alterations that underlies both diseases is oxidative stress (OxS), which appears as a result of lipid deposition in affected tissues. However, the molecular mechanisms that lead to OxS generation are different in each disease. Non-coding RNAs (ncRNAs) are RNA transcripts that do not encode proteins and function by regulating gene expression. In recent years, the involvement of ncRNAs in OxS modulation has become more recognized. This review summarizes the most recent advances regarding ncRNA-mediated regulation of OxS in atherosclerosis and NAFLD. In both diseases, ncRNAs can exert pro-oxidant or antioxidant functions by regulating gene targets and even other ncRNAs, positioning them as potential therapeutic targets. Interestingly, both diseases have common altered ncRNAs, suggesting that the same molecule can be targeted simultaneously when both diseases coexist. Finally, since some ncRNAs have already been used as therapeutic agents, their roles as potential drugs for the clinical management of atherosclerosis and NAFLD are analyzed.MDPIUniversidad Complutense de Madrid20232023-01-2420232023-01-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/105196reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica de Innovación 2021-2023 PID2021-123076OB-I00open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1051962026-06-02T12:44:21Z
dc.title.none.fl_str_mv Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
title Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
spellingShingle Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
Infante-Menéndez, Jorge
577.1
612.015
Oxidative stress
atherosclerosis
NAFLD
ncRNAs
miRNAs
lncRNAs
circRNAs
RNA-based therapies
Ciencias Biomédicas
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
title_short Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
title_full Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
title_fullStr Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
title_sort Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
dc.creator.none.fl_str_mv Infante-Menéndez, Jorge
González-López, Paula
Huertas-Lárez, Raquel
Gómez Hernández, María De La Almudena
Escribano Illanes, Óscar
author Infante-Menéndez, Jorge
author_facet Infante-Menéndez, Jorge
González-López, Paula
Huertas-Lárez, Raquel
Gómez Hernández, María De La Almudena
Escribano Illanes, Óscar
author_role author
author2 González-López, Paula
Huertas-Lárez, Raquel
Gómez Hernández, María De La Almudena
Escribano Illanes, Óscar
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
612.015
Oxidative stress
atherosclerosis
NAFLD
ncRNAs
miRNAs
lncRNAs
circRNAs
RNA-based therapies
Ciencias Biomédicas
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
topic 577.1
612.015
Oxidative stress
atherosclerosis
NAFLD
ncRNAs
miRNAs
lncRNAs
circRNAs
RNA-based therapies
Ciencias Biomédicas
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
description Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are pathologies related to ectopic fat accumulation, both of which are continuously increasing in prevalence. These threats are prompting researchers to develop effective therapies for their clinical management. One of the common pathophysiological alterations that underlies both diseases is oxidative stress (OxS), which appears as a result of lipid deposition in affected tissues. However, the molecular mechanisms that lead to OxS generation are different in each disease. Non-coding RNAs (ncRNAs) are RNA transcripts that do not encode proteins and function by regulating gene expression. In recent years, the involvement of ncRNAs in OxS modulation has become more recognized. This review summarizes the most recent advances regarding ncRNA-mediated regulation of OxS in atherosclerosis and NAFLD. In both diseases, ncRNAs can exert pro-oxidant or antioxidant functions by regulating gene targets and even other ncRNAs, positioning them as potential therapeutic targets. Interestingly, both diseases have common altered ncRNAs, suggesting that the same molecule can be targeted simultaneously when both diseases coexist. Finally, since some ncRNAs have already been used as therapeutic agents, their roles as potential drugs for the clinical management of atherosclerosis and NAFLD are analyzed.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-24
2023
2023-01-24
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/105196
url https://hdl.handle.net/20.500.14352/105196
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica de Innovación 2021-2023 PID2021-123076OB-I00
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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