Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study

The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fle...

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Autores: Yuste, Silvia, Ludwig, Iziar A., Romero Fabregat, Mª Paz, Piñol Felis, Carme, Catalán Santos, Úrsula, Pedret, Anna, Valls, Rosa M., Fernández Castillejo, Sara, Motilva Casado, Mª José, Macià i Puig, Ma Alba, Rubió Piqué, Laura
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/71100
Acceso en línea:https://doi.org/10.1002/mnfr.202001225
http://hdl.handle.net/10459.1/71100
Access Level:acceso abierto
Palabra clave:Anthocyanins
Aortic thickness
Bowman's space
Phenolic compounds
Red-fleshed apple
Sustained intake
UPLC-MS/MS
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spelling Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR StudyYuste, SilviaLudwig, Iziar A.Romero Fabregat, Mª PazPiñol Felis, CarmeCatalán Santos, ÚrsulaPedret, AnnaValls, Rosa M.Fernández Castillejo, SaraMotilva Casado, Mª JoséMacià i Puig, Ma AlbaRubió Piqué, LauraAnthocyaninsAortic thicknessBowman's spacePhenolic compoundsRed-fleshed appleSustained intakeUPLC-MS/MSThe present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.This study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2-2-R projects (co-funded by the European Social Fund, European Union). I.A.L. enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a grant from the University of Lleida. Ú.C. has a Pla estratègic de recerca i innovació en salut (PERIS) post-doctoral grant (SLT002/16/00239; Catalunya, Spain) from Generalitat de Catalunya. A.P. enjoys a post-doctoral grant (PTQ-15-08068; Spain). In addition, the authors are grateful to NUFRI SAT (Mollerussa, Lleida, Catalonia, Spain) for providing the red-fleshed apples. We are grateful to A. Martínez (Department of Medicine, University of Lleida) for helpful with the histological stains. Finally, we are grateful to SCT-Estabulari of the University of Lleida where the animal experiment was carried out.Wiley2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1002/mnfr.202001225http://hdl.handle.net/10459.1/71100reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-1-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-2-RVersió postprint del document publicat a https://doi.org/10.1002/mnfr.202001225Molecular Nutrition & Food Research, 2021, vol. 65, núm. 10, p. 2001225(c) Wiley, 2021info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/711002026-06-24T12:42:17Z
dc.title.none.fl_str_mv Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
title Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
spellingShingle Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
Yuste, Silvia
Anthocyanins
Aortic thickness
Bowman's space
Phenolic compounds
Red-fleshed apple
Sustained intake
UPLC-MS/MS
title_short Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
title_full Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
title_fullStr Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
title_full_unstemmed Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
title_sort Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
dc.creator.none.fl_str_mv Yuste, Silvia
Ludwig, Iziar A.
Romero Fabregat, Mª Paz
Piñol Felis, Carme
Catalán Santos, Úrsula
Pedret, Anna
Valls, Rosa M.
Fernández Castillejo, Sara
Motilva Casado, Mª José
Macià i Puig, Ma Alba
Rubió Piqué, Laura
author Yuste, Silvia
author_facet Yuste, Silvia
Ludwig, Iziar A.
Romero Fabregat, Mª Paz
Piñol Felis, Carme
Catalán Santos, Úrsula
Pedret, Anna
Valls, Rosa M.
Fernández Castillejo, Sara
Motilva Casado, Mª José
Macià i Puig, Ma Alba
Rubió Piqué, Laura
author_role author
author2 Ludwig, Iziar A.
Romero Fabregat, Mª Paz
Piñol Felis, Carme
Catalán Santos, Úrsula
Pedret, Anna
Valls, Rosa M.
Fernández Castillejo, Sara
Motilva Casado, Mª José
Macià i Puig, Ma Alba
Rubió Piqué, Laura
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anthocyanins
Aortic thickness
Bowman's space
Phenolic compounds
Red-fleshed apple
Sustained intake
UPLC-MS/MS
topic Anthocyanins
Aortic thickness
Bowman's space
Phenolic compounds
Red-fleshed apple
Sustained intake
UPLC-MS/MS
description The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/mnfr.202001225
http://hdl.handle.net/10459.1/71100
url https://doi.org/10.1002/mnfr.202001225
http://hdl.handle.net/10459.1/71100
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-1-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76943-C2-2-R
Versió postprint del document publicat a https://doi.org/10.1002/mnfr.202001225
Molecular Nutrition & Food Research, 2021, vol. 65, núm. 10, p. 2001225
dc.rights.none.fl_str_mv (c) Wiley, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley, 2021
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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