Association between markers of glycemia and carotid intima-media thickness: the MARK study
Background: Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. Methods: This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 +/- 8.5...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/15513 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/15513 |
| Access Level: | acceso abierto |
| Palabra clave: | Male Follow-Up Studies Carotid Arteries Adult Spain Blood Glucose Aged Cardiovascular Diseases Biomarkers Carotid Intima-Media Thickness Female Risk Factors Prevalence Incidence Middle Aged Cross-Sectional Studies Humans Glucose Tolerance Test Forecasting Glycated Hemoglobin A Prediabetic State España Incidencia Prevalencia Biomarcadores Femenino Hemoglobina A Glucada Masculino Estudios de Seguimiento Predicción Prueba de Tolerancia a la Glucosa Estudios Transversales Factores de Riesgo Humanos Persona de Mediana Edad Glucemia Estado Prediabético Anciano Grosor Intima-Media Carotídeo Enfermedades Cardiovasculares Arterias Carótidas Adulto Intima-media thickness Fasting plasma glucose Postprandial glucose Glycosylated hemoglobin |
| Sumario: | Background: Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. Methods: This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 +/- 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose, 104 subjects classified as prediabetes and 92 with type 2 diabetes mellitus. Carotid ultrasound was used to measure C-IMT and the presence of plaques. Fasting plasma glucose (mg/dl) and glycated hemoglobin (%) (HbA1c) were measured using standard enzymatic automated methods. Postprandial glucose (mg/dl) was self-measured by patients at home 2 h after meals (breakfast, lunch and dinner) for 1 day. Results: The C-IMT shows a positive correlation with fasting plasma glucose, postprandial glucose and HbA1c. Multiple linear regression analysis showed a positive association between HbA1c and C-IMT, with a 0.016 mm and 0.019 mm increase in mean and maximum C-IMT per 1 % increase in HbA1c. In addition, an association between fasting plasma glucose and C-IMT was found with an increase of 0.004 and 0.005 mm in mean and maximum C-IMT per 10 mg/dl in fasting plasma glucose. We also observed a graded association between fasting plasma glucose, postprandial glucose and HbA1c and the presence of carotid target organ damage (TOD), with an odds ratio of 1.013, 1.010 and 1.425, respectively. Conclusion: The results of this study suggest that the fasting plasma glucose and HbA1c, but not postprandial glucose, are associated with C-IMT media and maximum. The patients who present with a metabolic glucose alteration have more risk of developing carotid TOD. |
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