BMP8 and activated brown adipose tissue in human newborns

The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been...

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Autores: Urisarri, Adela, González García, Ismael, Estévez Salguero, Ánxela, Pata, María P., Milbank, Edward, López Ejeda, Noemí, Mandiá, Natalia, Grijota Martínez, María Carmen, Salgado, Carlos A., Nogueiras, Rubén, Diéguez, Carlos, Villarroya, Francesc, Fernández Real, José-Manuel, Couce, María L., López, Miguel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7210
Acceso en línea:https://hdl.handle.net/20.500.14352/7210
Access Level:acceso abierto
Palabra clave:577.112
611.018.26
BMP8
Adipose tissue
Brown
Newborns
Biología celular (Biología)
Bioquímica (Biología)
Neurociencias (Biológicas)
2407 Biología Celular
2302 Bioquímica
2490 Neurociencias
id ES_344ec0e4ebe47709eabb710cef21ff14
oai_identifier_str oai:docta.ucm.es:20.500.14352/7210
network_acronym_str ES
network_name_str España
repository_id_str
spelling BMP8 and activated brown adipose tissue in human newbornsUrisarri, AdelaGonzález García, IsmaelEstévez Salguero, ÁnxelaPata, María P.Milbank, EdwardLópez Ejeda, NoemíMandiá, NataliaGrijota Martínez, María CarmenSalgado, Carlos A.Nogueiras, RubénDiéguez, CarlosVillarroya, FrancescFernández Real, José-ManuelCouce, María L.López, Miguel577.112611.018.26BMP8Adipose tissueBrownNewbornsBiología celular (Biología)Bioquímica (Biología)Neurociencias (Biológicas)2407 Biología Celular2302 Bioquímica2490 NeurocienciasThe classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.Nature Publishing GroupUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7210reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/72102026-06-02T12:44:21Z
dc.title.none.fl_str_mv BMP8 and activated brown adipose tissue in human newborns
title BMP8 and activated brown adipose tissue in human newborns
spellingShingle BMP8 and activated brown adipose tissue in human newborns
Urisarri, Adela
577.112
611.018.26
BMP8
Adipose tissue
Brown
Newborns
Biología celular (Biología)
Bioquímica (Biología)
Neurociencias (Biológicas)
2407 Biología Celular
2302 Bioquímica
2490 Neurociencias
title_short BMP8 and activated brown adipose tissue in human newborns
title_full BMP8 and activated brown adipose tissue in human newborns
title_fullStr BMP8 and activated brown adipose tissue in human newborns
title_full_unstemmed BMP8 and activated brown adipose tissue in human newborns
title_sort BMP8 and activated brown adipose tissue in human newborns
dc.creator.none.fl_str_mv Urisarri, Adela
González García, Ismael
Estévez Salguero, Ánxela
Pata, María P.
Milbank, Edward
López Ejeda, Noemí
Mandiá, Natalia
Grijota Martínez, María Carmen
Salgado, Carlos A.
Nogueiras, Rubén
Diéguez, Carlos
Villarroya, Francesc
Fernández Real, José-Manuel
Couce, María L.
López, Miguel
author Urisarri, Adela
author_facet Urisarri, Adela
González García, Ismael
Estévez Salguero, Ánxela
Pata, María P.
Milbank, Edward
López Ejeda, Noemí
Mandiá, Natalia
Grijota Martínez, María Carmen
Salgado, Carlos A.
Nogueiras, Rubén
Diéguez, Carlos
Villarroya, Francesc
Fernández Real, José-Manuel
Couce, María L.
López, Miguel
author_role author
author2 González García, Ismael
Estévez Salguero, Ánxela
Pata, María P.
Milbank, Edward
López Ejeda, Noemí
Mandiá, Natalia
Grijota Martínez, María Carmen
Salgado, Carlos A.
Nogueiras, Rubén
Diéguez, Carlos
Villarroya, Francesc
Fernández Real, José-Manuel
Couce, María L.
López, Miguel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.112
611.018.26
BMP8
Adipose tissue
Brown
Newborns
Biología celular (Biología)
Bioquímica (Biología)
Neurociencias (Biológicas)
2407 Biología Celular
2302 Bioquímica
2490 Neurociencias
topic 577.112
611.018.26
BMP8
Adipose tissue
Brown
Newborns
Biología celular (Biología)
Bioquímica (Biología)
Neurociencias (Biológicas)
2407 Biología Celular
2302 Bioquímica
2490 Neurociencias
description The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7210
url https://hdl.handle.net/20.500.14352/7210
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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