Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy

Background: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990...

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Autores: Grau, Juan José, Palmero, Ramón, Marmol, Maribel, Domingo Domènech, Josep Maria, Monzó Planella, Mariano, Fuster Obregón, Josep, Vidal Pérez, Oscar, Fondevila Campo, Constantino, García-Valdecasas Salgado, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/7602
Acceso en línea:https://hdl.handle.net/2445/7602
Access Level:acceso abierto
Palabra clave:Aparell digestiu
Càncer
Quimioteràpia
Gastric cancer
Chemotherapy
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spelling Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapyGrau, Juan JoséPalmero, RamónMarmol, MaribelDomingo Domènech, Josep MariaMonzó Planella, MarianoFuster Obregón, JosepVidal Pérez, OscarFondevila Campo, ConstantinoGarcía-Valdecasas Salgado, Juan CarlosAparell digestiuCàncerQuimioteràpiaGastric cancerChemotherapyBackground: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10¿20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months. Results: Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables. Conclusion: The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy.BioMed Central200920092006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/7602Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a http://dx.doi.org/10.1186/1477-7819-4-53World Journal of Surgical Oncology, 2006, vol. 4, núm. 53http://dx.doi.org/10.1186/1477-7819-4-53cc-by, (c) Grau et al., 2006http://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/76022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
title Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
spellingShingle Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
Grau, Juan José
Aparell digestiu
Càncer
Quimioteràpia
Gastric cancer
Chemotherapy
title_short Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
title_full Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
title_fullStr Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
title_full_unstemmed Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
title_sort Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
dc.creator.none.fl_str_mv Grau, Juan José
Palmero, Ramón
Marmol, Maribel
Domingo Domènech, Josep Maria
Monzó Planella, Mariano
Fuster Obregón, Josep
Vidal Pérez, Oscar
Fondevila Campo, Constantino
García-Valdecasas Salgado, Juan Carlos
author Grau, Juan José
author_facet Grau, Juan José
Palmero, Ramón
Marmol, Maribel
Domingo Domènech, Josep Maria
Monzó Planella, Mariano
Fuster Obregón, Josep
Vidal Pérez, Oscar
Fondevila Campo, Constantino
García-Valdecasas Salgado, Juan Carlos
author_role author
author2 Palmero, Ramón
Marmol, Maribel
Domingo Domènech, Josep Maria
Monzó Planella, Mariano
Fuster Obregón, Josep
Vidal Pérez, Oscar
Fondevila Campo, Constantino
García-Valdecasas Salgado, Juan Carlos
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aparell digestiu
Càncer
Quimioteràpia
Gastric cancer
Chemotherapy
topic Aparell digestiu
Càncer
Quimioteràpia
Gastric cancer
Chemotherapy
description Background: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10¿20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months. Results: Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables. Conclusion: The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy.
publishDate 2006
dc.date.none.fl_str_mv 2006
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/7602
url https://hdl.handle.net/2445/7602
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a http://dx.doi.org/10.1186/1477-7819-4-53
World Journal of Surgical Oncology, 2006, vol. 4, núm. 53
http://dx.doi.org/10.1186/1477-7819-4-53
dc.rights.none.fl_str_mv cc-by, (c) Grau et al., 2006
http://creativecommons.org/licenses/by/2.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by, (c) Grau et al., 2006
http://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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