Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant l...

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Detalhes bibliográficos
Autores: Muñoz López, Ruth, Guzmán Solís, Eduardo, Velázquez, Maria Mercedes, Fernández Peña, Laura, Merchán, María Dolores, Maestro, Armando, Ortega Gómez, Francisco, González Rubio, Ramón
Tipo de documento: artigo
Data de publicação:2020
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/8289
Acesso em linha:https://hdl.handle.net/20.500.14352/8289
Access Level:Acceso aberto
Palavra-chave:particles
lipids
Langmuir monolayer
lung surfactant
pollution
dilational rheology
toxicity
carbon nanosheets
Química física (Física)
Química física (Química)
2210 Química Física
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spelling Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir MonolayersMuñoz López, RuthGuzmán Solís, EduardoVelázquez, Maria MercedesFernández Peña, LauraMerchán, María DoloresMaestro, ArmandoOrtega Gómez, FranciscoGonzález Rubio, RamónparticleslipidsLangmuir monolayerlung surfactantpollutiondilational rheologytoxicitycarbon nanosheetsQuímica física (Física)Química física (Química)2210 Química FísicaCarbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.MDPIUniversidad Complutense de Madrid20202020-01-1020202020-01-10journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8289reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/82892026-06-02T12:44:21Z
dc.title.none.fl_str_mv Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
spellingShingle Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
Muñoz López, Ruth
particles
lipids
Langmuir monolayer
lung surfactant
pollution
dilational rheology
toxicity
carbon nanosheets
Química física (Física)
Química física (Química)
2210 Química Física
title_short Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_full Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_fullStr Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_full_unstemmed Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_sort Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
dc.creator.none.fl_str_mv Muñoz López, Ruth
Guzmán Solís, Eduardo
Velázquez, Maria Mercedes
Fernández Peña, Laura
Merchán, María Dolores
Maestro, Armando
Ortega Gómez, Francisco
González Rubio, Ramón
author Muñoz López, Ruth
author_facet Muñoz López, Ruth
Guzmán Solís, Eduardo
Velázquez, Maria Mercedes
Fernández Peña, Laura
Merchán, María Dolores
Maestro, Armando
Ortega Gómez, Francisco
González Rubio, Ramón
author_role author
author2 Guzmán Solís, Eduardo
Velázquez, Maria Mercedes
Fernández Peña, Laura
Merchán, María Dolores
Maestro, Armando
Ortega Gómez, Francisco
González Rubio, Ramón
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv particles
lipids
Langmuir monolayer
lung surfactant
pollution
dilational rheology
toxicity
carbon nanosheets
Química física (Física)
Química física (Química)
2210 Química Física
topic particles
lipids
Langmuir monolayer
lung surfactant
pollution
dilational rheology
toxicity
carbon nanosheets
Química física (Física)
Química física (Química)
2210 Química Física
description Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-10
2020
2020-01-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8289
url https://hdl.handle.net/20.500.14352/8289
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405794497200128
score 15,301603

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