HLA association with the susceptibility to anti-synthetase syndrome.
Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by se...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/358806 |
| Acceso en línea: | http://hdl.handle.net/10261/358806 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-synthetase syndrome Anti-Jo-1 antibodies HLA HLA-DRB1*03:01 HLA-B*08:01 HLA-DRB1*07:01 |
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ES_342cc9bba6d573c599f4ea7eb0d602ec |
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oai:digital.csic.es:10261/358806 |
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ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
HLA association with the susceptibility to anti-synthetase syndrome. |
| title |
HLA association with the susceptibility to anti-synthetase syndrome. |
| spellingShingle |
HLA association with the susceptibility to anti-synthetase syndrome. Remuzgo-Martínez, Sara Anti-synthetase syndrome Anti-Jo-1 antibodies HLA HLA-DRB1*03:01 HLA-B*08:01 HLA-DRB1*07:01 |
| title_short |
HLA association with the susceptibility to anti-synthetase syndrome. |
| title_full |
HLA association with the susceptibility to anti-synthetase syndrome. |
| title_fullStr |
HLA association with the susceptibility to anti-synthetase syndrome. |
| title_full_unstemmed |
HLA association with the susceptibility to anti-synthetase syndrome. |
| title_sort |
HLA association with the susceptibility to anti-synthetase syndrome. |
| dc.creator.none.fl_str_mv |
Remuzgo-Martínez, Sara Atienza-Mateo, Belén Ocejo-Vinyals, J. Gonzalo Pulito-Cueto, Verónica Prieto-Peña, Diana Genre, Fernanda Márquez, Ana Llorca, Javier Mora Cuesta, Víctor M. Fernández, David Iturbe Riesco, Laura Ortego-Centeno, Norberto Pérez Gómez, Nair Mera, Antonio Martínez Barrio, Julia López Longo, Francisco Javier Lera-Gómez, Leticia Moriano, Clara Díez, Elvira Tornero, Eva Calvo-Alén, Jaime Romero-Bueno, Fredeswinda Sánchez-Pernaute, Olga Nuño, Laura Bonilla, Gema Grafia, Ignacio Prieto-González, Sergio Narváez, Javier Trallero-Araguas, Ernesto Selva-O'Callaghan, Albert Gualillo, Oreste Martín, Javier Cabagna, Lorenzo Catañeda, Santos Cifrian, José M. Renzoni, Elizabetta A. López-Mejías, Raquel González-Gay, Miguel A. |
| author |
Remuzgo-Martínez, Sara |
| author_facet |
Remuzgo-Martínez, Sara Atienza-Mateo, Belén Ocejo-Vinyals, J. Gonzalo Pulito-Cueto, Verónica Prieto-Peña, Diana Genre, Fernanda Márquez, Ana Llorca, Javier Mora Cuesta, Víctor M. Fernández, David Iturbe Riesco, Laura Ortego-Centeno, Norberto Pérez Gómez, Nair Mera, Antonio Martínez Barrio, Julia López Longo, Francisco Javier Lera-Gómez, Leticia Moriano, Clara Díez, Elvira Tornero, Eva Calvo-Alén, Jaime Romero-Bueno, Fredeswinda Sánchez-Pernaute, Olga Nuño, Laura Bonilla, Gema Grafia, Ignacio Prieto-González, Sergio Narváez, Javier Trallero-Araguas, Ernesto Selva-O'Callaghan, Albert Gualillo, Oreste Martín, Javier Cabagna, Lorenzo Catañeda, Santos Cifrian, José M. Renzoni, Elizabetta A. López-Mejías, Raquel González-Gay, Miguel A. |
| author_role |
author |
| author2 |
Atienza-Mateo, Belén Ocejo-Vinyals, J. Gonzalo Pulito-Cueto, Verónica Prieto-Peña, Diana Genre, Fernanda Márquez, Ana Llorca, Javier Mora Cuesta, Víctor M. Fernández, David Iturbe Riesco, Laura Ortego-Centeno, Norberto Pérez Gómez, Nair Mera, Antonio Martínez Barrio, Julia López Longo, Francisco Javier Lera-Gómez, Leticia Moriano, Clara Díez, Elvira Tornero, Eva Calvo-Alén, Jaime Romero-Bueno, Fredeswinda Sánchez-Pernaute, Olga Nuño, Laura Bonilla, Gema Grafia, Ignacio Prieto-González, Sergio Narváez, Javier Trallero-Araguas, Ernesto Selva-O'Callaghan, Albert Gualillo, Oreste Martín, Javier Cabagna, Lorenzo Catañeda, Santos Cifrian, José M. Renzoni, Elizabetta A. López-Mejías, Raquel González-Gay, Miguel A. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Foundation for Research in Rheumatology Instituto de Salud Carlos III European Commission Servicio Cántabro de Salud Instituto de Investigación Marqués de Valdecilla Xunta de Galicia Scleroderma and Raynaud's UK Versus Arthritis Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Anti-synthetase syndrome Anti-Jo-1 antibodies HLA HLA-DRB1*03:01 HLA-B*08:01 HLA-DRB1*07:01 |
| topic |
Anti-synthetase syndrome Anti-Jo-1 antibodies HLA HLA-DRB1*03:01 HLA-B*08:01 HLA-DRB1*07:01 |
| description |
Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P = 1.56E–09, odds ratio–OR [95% confidence interval–CI] = 2.54 [1.84–3.50] and 21.4% versus 5.5%, P = 18.95E–18, OR [95% CI] = 4.73 [3.18–7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P = 0.0003, OR [95% CI] = 0.48 [0.31–0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P = 0.001, OR [95% CI] = 2.54 [1.39–4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions: Our results support the association of the HLA complex with the susceptibility to ASSD. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/358806 |
| url |
http://hdl.handle.net/10261/358806 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
http://dx.doi.org/10.1016/j.jbspin.2020.105115 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869405793703428096 |
| spelling |
HLA association with the susceptibility to anti-synthetase syndrome.Remuzgo-Martínez, SaraAtienza-Mateo, BelénOcejo-Vinyals, J. GonzaloPulito-Cueto, VerónicaPrieto-Peña, DianaGenre, FernandaMárquez, AnaLlorca, JavierMora Cuesta, Víctor M.Fernández, David IturbeRiesco, LauraOrtego-Centeno, NorbertoPérez Gómez, NairMera, AntonioMartínez Barrio, JuliaLópez Longo, Francisco JavierLera-Gómez, LeticiaMoriano, ClaraDíez, ElviraTornero, EvaCalvo-Alén, JaimeRomero-Bueno, FredeswindaSánchez-Pernaute, OlgaNuño, LauraBonilla, GemaGrafia, IgnacioPrieto-González, SergioNarváez, JavierTrallero-Araguas, ErnestoSelva-O'Callaghan, AlbertGualillo, OresteMartín, JavierCabagna, LorenzoCatañeda, SantosCifrian, José M.Renzoni, Elizabetta A.López-Mejías, RaquelGonzález-Gay, Miguel A.Anti-synthetase syndromeAnti-Jo-1 antibodiesHLAHLA-DRB1*03:01HLA-B*08:01HLA-DRB1*07:01Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P = 1.56E–09, odds ratio–OR [95% confidence interval–CI] = 2.54 [1.84–3.50] and 21.4% versus 5.5%, P = 18.95E–18, OR [95% CI] = 4.73 [3.18–7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P = 0.0003, OR [95% CI] = 0.48 [0.31–0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P = 0.001, OR [95% CI] = 2.54 [1.39–4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions: Our results support the association of the HLA complex with the susceptibility to ASSD.This study was partially supported by grants from the Foundation for Research in Rheumatology (FOREUM); SR-M is supported by funds of the RETICS Program [grant number RD16/0012/0009] from the `Instituto de Salud Carlos III´ (ISCIII), co-funded by the European Regional Development Fund (ERDF); BA-M is a recipient of a ‘López Albo’ Post-Residency Programme funded by Servicio Cántabro de Salud; VP-C is supported by a pre-doctoral grant from IDIVAL [grant number PREVAL 18/01]; LL-G is supported by funds of ISCIII, co-funded by ERDF [grant number PI18/00042]; OG is beneficiary of a grant funded by Xunta de Galicia, Consellería de Educación, Universidade e Formación Profesional and Consellería de Economía, Emprego e Industria (GAIN), GPC IN607B2019/10; EAR is partially supported by Versus Arthritis [grant number 20719] and by Scleroderma and Raynaud's UK [grant number BR11]; RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, ‘Investing in your future’) [grant number CP16/00033].Peer reviewedFoundation for Research in RheumatologyInstituto de Salud Carlos IIIEuropean CommissionServicio Cántabro de SaludInstituto de Investigación Marqués de ValdecillaXunta de GaliciaScleroderma and Raynaud's UKVersus ArthritisConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420212024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/358806reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.jbspin.2020.105115Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3588062026-05-22T06:33:51Z |
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15.812429 |