Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone

The work was supported by 3M Foundation through a 3M Non-tenured Faculty Award (CA). Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the MRSEC program. The funders had no role in study design, data col...

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Detalles Bibliográficos
Autores: Li, Yuping, Aparicio, Conrado
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3672
Acceso en línea:http://hdl.handle.net/20.500.12328/3672
https://dx.doi.org/10.1371/journal.pone.0076782
Access Level:acceso abierto
Palabra clave:Odontologia
Odontología
Dentistry
616.3
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spelling Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of boneLi, YupingAparicio, ConradoOdontologiaOdontologíaDentistry616.3The work was supported by 3M Foundation through a 3M Non-tenured Faculty Award (CA). Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the MRSEC program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) nanocrystals that are embedded within collagen fibrils with their c-axes arranged roughly parallel to the long axis of the fibrils. Here we discern the ultra-structure of biomimetic mineralized collagen fibrils (MCFs) as consisting of bundles of subfibrils with approximately 10 nm diameter; each one with an organic-inorganic core-shell structure. Through an amorphous calcium phosphate precursor phase the HA nanocrystals were specifically grown along the longitudinal direction of the collagen microfibrils and encapsulated them within the crystal lattice. They intercalated throughout the collagen fibrils such that the mineral phase surrounded the surface of collagen microfibrils forming an interdigitated network. It appears that this arrangement of collagen microfibrils in collagen fibrils is responsible for the observed ultrastructure. Such a subfibrillar nanostructure in MCFs was identified in both synthetic and natural bone, suggesting this is the basic building block of collagen-based hard tissues. Insights into the ultrastructure of mineralized collagen fibrils have the potential to advance our understanding on the biomineralization principles and the relationship between bone’s structure and mechanical properties, including fracture toughness mechanisms. We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.info:eu-repo/semantics/publishedVersionPublic Library of Science2013info:eu-repo/semantics/article12http://hdl.handle.net/20.500.12328/3672https://dx.doi.org/10.1371/journal.pone.0076782reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS ONE8;9https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076782© 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/36722026-05-29T05:05:01Z
dc.title.none.fl_str_mv Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
title Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
spellingShingle Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
Li, Yuping
Odontologia
Odontología
Dentistry
616.3
title_short Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
title_full Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
title_fullStr Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
title_full_unstemmed Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
title_sort Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
dc.creator.none.fl_str_mv Li, Yuping
Aparicio, Conrado
author Li, Yuping
author_facet Li, Yuping
Aparicio, Conrado
author_role author
author2 Aparicio, Conrado
author2_role author
dc.subject.none.fl_str_mv Odontologia
Odontología
Dentistry
616.3
topic Odontologia
Odontología
Dentistry
616.3
description The work was supported by 3M Foundation through a 3M Non-tenured Faculty Award (CA). Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the MRSEC program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3672
https://dx.doi.org/10.1371/journal.pone.0076782
url http://hdl.handle.net/20.500.12328/3672
https://dx.doi.org/10.1371/journal.pone.0076782
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE
8;9
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076782
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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