Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases

Llorente, Xavier; Esteruelas Navarro, Gerard; Bonilla Vidal, Lorena; Garnica Agudelo, Mariana; Filgaira Enri, Ingrid; Lopez-Ramajo, Daniel; Gong, Ruoyi C.; Soler Prat, Concepció; Espina García, Marta; García López, María Luisa; Manils Pacheco, Joan; Pujol Cubells, Montserrat; Sánchez-López, E. (Elena)

Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases

Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost eﬀective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotro...

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Autores:	Llorente, Xavier, Esteruelas Navarro, Gerard, Bonilla Vidal, Lorena, Garnica Agudelo, Mariana, Filgaira Enri, Ingrid, Lopez-Ramajo, Daniel, Gong, Ruoyi C., Soler Prat, Concepció, Espina García, Marta, García López, María Luisa, Manils Pacheco, Joan, Pujol Cubells, Montserrat, Sánchez-López, E. (Elena)
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/199761
Acceso en línea:	https://hdl.handle.net/2445/199761
Access Level:	acceso abierto
Palabra clave:	Nanopartícules Malalties de la pell Nanoparticles Skin diseases

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spelling	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin DiseasesLlorente, XavierEsteruelas Navarro, GerardBonilla Vidal, LorenaGarnica Agudelo, MarianaFilgaira Enri, IngridLopez-Ramajo, DanielGong, Ruoyi C.Soler Prat, ConcepcióEspina García, MartaGarcía López, María LuisaManils Pacheco, JoanPujol Cubells, MontserratSánchez-López, E. (Elena)NanopartículesMalalties de la pellNanoparticlesSkin diseasesNanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost eﬀective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative eﬀects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment eﬃcacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions.MDPI2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/2445/199761Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms24098053International Journal of Molecular Sciences, 2023, vol. 24, p. 8053https://doi.org/10.3390/ijms24098053cc-by (c) Llorente, Xavier et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1997612026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
title	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
spellingShingle	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases Llorente, Xavier Nanopartícules Malalties de la pell Nanoparticles Skin diseases
title_short	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
title_full	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
title_fullStr	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
title_full_unstemmed	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
title_sort	Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases
dc.creator.none.fl_str_mv	Llorente, Xavier Esteruelas Navarro, Gerard Bonilla Vidal, Lorena Garnica Agudelo, Mariana Filgaira Enri, Ingrid Lopez-Ramajo, Daniel Gong, Ruoyi C. Soler Prat, Concepció Espina García, Marta García López, María Luisa Manils Pacheco, Joan Pujol Cubells, Montserrat Sánchez-López, E. (Elena)
author	Llorente, Xavier
author_facet	Llorente, Xavier Esteruelas Navarro, Gerard Bonilla Vidal, Lorena Garnica Agudelo, Mariana Filgaira Enri, Ingrid Lopez-Ramajo, Daniel Gong, Ruoyi C. Soler Prat, Concepció Espina García, Marta García López, María Luisa Manils Pacheco, Joan Pujol Cubells, Montserrat Sánchez-López, E. (Elena)
author_role	author
author2	Esteruelas Navarro, Gerard Bonilla Vidal, Lorena Garnica Agudelo, Mariana Filgaira Enri, Ingrid Lopez-Ramajo, Daniel Gong, Ruoyi C. Soler Prat, Concepció Espina García, Marta García López, María Luisa Manils Pacheco, Joan Pujol Cubells, Montserrat Sánchez-López, E. (Elena)
author2_role	author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Nanopartícules Malalties de la pell Nanoparticles Skin diseases
topic	Nanopartícules Malalties de la pell Nanoparticles Skin diseases
description	Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost eﬀective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative eﬀects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment eﬃcacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/199761
url	https://hdl.handle.net/2445/199761
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/ijms24098053 International Journal of Molecular Sciences, 2023, vol. 24, p. 8053 https://doi.org/10.3390/ijms24098053
dc.rights.none.fl_str_mv	cc-by (c) Llorente, Xavier et al., 2023 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Llorente, Xavier et al., 2023 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases

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