Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats

Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate th...

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Autores: Arrieta-Villegas, Claudia|||0000-0002-8839-8660, Perálvarez, Tania, Vidal Barba, Enric|||0000-0002-4965-3286, Puighibet Maso, Zöe, Moll, Xavier|||0000-0002-2992-9361, Canturri, Albert, Sevilla, Iker A.|||0000-0003-3968-3390, Espada, Yvonne|||0000-0003-1556-6587, Juste, Ramón A.|||0000-0001-6037-5873, Domingo, Mariano|||0000-0002-9623-4826, Pérez de Val, Bernat|||0000-0003-3127-9182
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:201161
Acceso en línea:https://ddd.uab.cat/record/201161
https://dx.doi.org/urn:doi:10.1371/journal.pone.0196948
Access Level:acceso abierto
Palabra clave:Animals
BCG Vaccine
Goats
Hot Temperature
Lung
Mycobacterium bovis
Tuberculosis
Vaccination
Vaccines, Inactivated
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spelling Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goatsArrieta-Villegas, Claudia|||0000-0002-8839-8660Perálvarez, TaniaVidal Barba, Enric|||0000-0002-4965-3286Puighibet Maso, ZöeMoll, Xavier|||0000-0002-2992-9361Canturri, AlbertSevilla, Iker A.|||0000-0003-3968-3390Espada, Yvonne|||0000-0003-1556-6587Juste, Ramón A.|||0000-0001-6037-5873Domingo, Mariano|||0000-0002-9623-4826Pérez de Val, Bernat|||0000-0003-3127-9182AnimalsBCG VaccineGoatsHot TemperatureLungMycobacterium bovisTuberculosisVaccinationVaccines, InactivatedTuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate the efficacy of parenteral vaccination of goats with a heat-inactivated Mycobacterium bovis (HIMB) vaccine, and compare it to M. bovis Bacille Calm-ette-Guérin (BCG) vaccine. Twenty-four goat kids were divided in 3 groups as following: HIMB vaccinated group (n = 8), BCG vaccinated group (n = 8) and unvaccinated group (n = 8). Afterwards, goats were experimentally challenged with Mycobacterium caprae by the endobronchial route. Antigen specific interferon-γ release assays and serology were performed after vaccination and challenge. Pathological and bacteriological parameters were evaluated after necropsy at 9 weeks post-challenge (p.c.). HIMB vaccine showed similar levels of protection to BCG in terms of volume reduction of thoracic TB lesions, presence of extra-pulmonary lesions, as well as a slight reduction of bacterial load in pulmonary lymph nodes. Moreover, HIMB vaccine did not induce interferences on the interferon-γ release assay based on reagents previously developed to differentiate infected from BCG vaccinated individuals. The results indicate that HIMB is a suitable vaccine candidate for further larger-scale trials under field conditions in goats. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/201161https://dx.doi.org/urn:doi:10.1371/journal.pone.0196948reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2011612026-06-06T12:50:31Z
dc.title.none.fl_str_mv Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
title Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
spellingShingle Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
Arrieta-Villegas, Claudia|||0000-0002-8839-8660
Animals
BCG Vaccine
Goats
Hot Temperature
Lung
Mycobacterium bovis
Tuberculosis
Vaccination
Vaccines, Inactivated
title_short Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
title_full Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
title_fullStr Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
title_full_unstemmed Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
title_sort Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
dc.creator.none.fl_str_mv Arrieta-Villegas, Claudia|||0000-0002-8839-8660
Perálvarez, Tania
Vidal Barba, Enric|||0000-0002-4965-3286
Puighibet Maso, Zöe
Moll, Xavier|||0000-0002-2992-9361
Canturri, Albert
Sevilla, Iker A.|||0000-0003-3968-3390
Espada, Yvonne|||0000-0003-1556-6587
Juste, Ramón A.|||0000-0001-6037-5873
Domingo, Mariano|||0000-0002-9623-4826
Pérez de Val, Bernat|||0000-0003-3127-9182
author Arrieta-Villegas, Claudia|||0000-0002-8839-8660
author_facet Arrieta-Villegas, Claudia|||0000-0002-8839-8660
Perálvarez, Tania
Vidal Barba, Enric|||0000-0002-4965-3286
Puighibet Maso, Zöe
Moll, Xavier|||0000-0002-2992-9361
Canturri, Albert
Sevilla, Iker A.|||0000-0003-3968-3390
Espada, Yvonne|||0000-0003-1556-6587
Juste, Ramón A.|||0000-0001-6037-5873
Domingo, Mariano|||0000-0002-9623-4826
Pérez de Val, Bernat|||0000-0003-3127-9182
author_role author
author2 Perálvarez, Tania
Vidal Barba, Enric|||0000-0002-4965-3286
Puighibet Maso, Zöe
Moll, Xavier|||0000-0002-2992-9361
Canturri, Albert
Sevilla, Iker A.|||0000-0003-3968-3390
Espada, Yvonne|||0000-0003-1556-6587
Juste, Ramón A.|||0000-0001-6037-5873
Domingo, Mariano|||0000-0002-9623-4826
Pérez de Val, Bernat|||0000-0003-3127-9182
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Animals
BCG Vaccine
Goats
Hot Temperature
Lung
Mycobacterium bovis
Tuberculosis
Vaccination
Vaccines, Inactivated
topic Animals
BCG Vaccine
Goats
Hot Temperature
Lung
Mycobacterium bovis
Tuberculosis
Vaccination
Vaccines, Inactivated
description Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate the efficacy of parenteral vaccination of goats with a heat-inactivated Mycobacterium bovis (HIMB) vaccine, and compare it to M. bovis Bacille Calm-ette-Guérin (BCG) vaccine. Twenty-four goat kids were divided in 3 groups as following: HIMB vaccinated group (n = 8), BCG vaccinated group (n = 8) and unvaccinated group (n = 8). Afterwards, goats were experimentally challenged with Mycobacterium caprae by the endobronchial route. Antigen specific interferon-γ release assays and serology were performed after vaccination and challenge. Pathological and bacteriological parameters were evaluated after necropsy at 9 weeks post-challenge (p.c.). HIMB vaccine showed similar levels of protection to BCG in terms of volume reduction of thoracic TB lesions, presence of extra-pulmonary lesions, as well as a slight reduction of bacterial load in pulmonary lymph nodes. Moreover, HIMB vaccine did not induce interferences on the interferon-γ release assay based on reagents previously developed to differentiate infected from BCG vaccinated individuals. The results indicate that HIMB is a suitable vaccine candidate for further larger-scale trials under field conditions in goats.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/201161
https://dx.doi.org/urn:doi:10.1371/journal.pone.0196948
url https://ddd.uab.cat/record/201161
https://dx.doi.org/urn:doi:10.1371/journal.pone.0196948
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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