Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet

Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effec...

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Autores: Martín Masot, Rafael, Jiménez-Muñoz, María, Herrador-López, Marta, Navas-López, Víctor Manuel, Obis Monné, Èlia, Jové Font, Mariona, Pamplona Gras, Reinald, Nestares, Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/464243
Acceso en línea:https://doi.org/10.3390/nu15132871
https://hdl.handle.net/10459.1/464243
Access Level:acceso abierto
Palabra clave:Celiac disease
Gluten-free diet
Metabolomics
Children
Immune
Intestinal
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spelling Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free DietMartín Masot, RafaelJiménez-Muñoz, MaríaHerrador-López, MartaNavas-López, Víctor ManuelObis Monné, ÈliaJové Font, MarionaPamplona Gras, ReinaldNestares, TeresaCeliac diseaseGluten-free dietMetabolomicsChildrenImmuneIntestinalCeliac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. By analyzing metabolites, we can gain insights into the reasons behind CD’s occurrence, as well as better comprehend the impact of treatment initiation on patients. In this review, we present a collection of articles that showcase the latest breakthroughs in the field of metabolomics in pediatric CD, with the aim of trying to identify CD biomarkers for both early diagnosis and treatment monitoring. These advancements shed light on the potential of metabolomic analysis in enhancing our understanding of the disease and improving diagnostic and therapeutic strategies. More studies need to be designed to cover metabolic profiles in subjects at risk of developing the disease, as well as those analyzing biomarkers for follow-up treatment with a GFD.This research was funded by the FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades Projects FEDER No B-AGR-658 and Excelencia P21_00101. It was also partially funded with the grant “Investigation grant program by the Association of Celiacs and Sensitive to Gluten of the Community of Madrid” and the Government of Catalonia: Agency for the Management of University and Resarch Grants (2021SGR00990). María Jiménez-Muñoz is grateful to the Ph.D. program “Nutrición y Ciencias de los Alimentos” from the University of GranadaMDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/nu15132871https://hdl.handle.net/10459.1/464243reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3390/nu15132871Nutrients, 2023, vol. 15, núm. 13, 2871cc-by (c) Rafael Martín-Masot et al., 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4642432026-06-24T12:42:17Z
dc.title.none.fl_str_mv Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
title Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
spellingShingle Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
Martín Masot, Rafael
Celiac disease
Gluten-free diet
Metabolomics
Children
Immune
Intestinal
title_short Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
title_full Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
title_fullStr Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
title_full_unstemmed Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
title_sort Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet
dc.creator.none.fl_str_mv Martín Masot, Rafael
Jiménez-Muñoz, María
Herrador-López, Marta
Navas-López, Víctor Manuel
Obis Monné, Èlia
Jové Font, Mariona
Pamplona Gras, Reinald
Nestares, Teresa
author Martín Masot, Rafael
author_facet Martín Masot, Rafael
Jiménez-Muñoz, María
Herrador-López, Marta
Navas-López, Víctor Manuel
Obis Monné, Èlia
Jové Font, Mariona
Pamplona Gras, Reinald
Nestares, Teresa
author_role author
author2 Jiménez-Muñoz, María
Herrador-López, Marta
Navas-López, Víctor Manuel
Obis Monné, Èlia
Jové Font, Mariona
Pamplona Gras, Reinald
Nestares, Teresa
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Celiac disease
Gluten-free diet
Metabolomics
Children
Immune
Intestinal
topic Celiac disease
Gluten-free diet
Metabolomics
Children
Immune
Intestinal
description Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. By analyzing metabolites, we can gain insights into the reasons behind CD’s occurrence, as well as better comprehend the impact of treatment initiation on patients. In this review, we present a collection of articles that showcase the latest breakthroughs in the field of metabolomics in pediatric CD, with the aim of trying to identify CD biomarkers for both early diagnosis and treatment monitoring. These advancements shed light on the potential of metabolomic analysis in enhancing our understanding of the disease and improving diagnostic and therapeutic strategies. More studies need to be designed to cover metabolic profiles in subjects at risk of developing the disease, as well as those analyzing biomarkers for follow-up treatment with a GFD.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/nu15132871
https://hdl.handle.net/10459.1/464243
url https://doi.org/10.3390/nu15132871
https://hdl.handle.net/10459.1/464243
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/nu15132871
Nutrients, 2023, vol. 15, núm. 13, 2871
dc.rights.none.fl_str_mv cc-by (c) Rafael Martín-Masot et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Rafael Martín-Masot et al., 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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