Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis

Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none...

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Autores: Clemente, C., Bosch i Genover, Jaume, Rodés, J., Arroyo, Vicente, Mas Comas, Ana M., Maragall, S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1977
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/18642
Acceso en línea:https://hdl.handle.net/2445/18642
Access Level:acceso abierto
Palabra clave:Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastrointestinal hemorrhage
Endotoxins
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spelling Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosisClemente, C.Bosch i Genover, JaumeRodés, J.Arroyo, VicenteMas Comas, Ana M.Maragall, S.Insuficiència renal agudaCirrosi hepàticaHemorràgia gastrointestinalEndotoxinesGastritisHepatic cirrhosisAcute renal failureGastritisGastrointestinal hemorrhageEndotoxinsForty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.BMJ Group1977info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/18642Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.18.7.556Gut, 1977, vol. 18, núm. 7, p. 556-560http://dx.doi.org/10.1136/gut.18.7.556(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/186422026-05-27T06:46:51Z
dc.title.none.fl_str_mv Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
spellingShingle Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
Clemente, C.
Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
title_short Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_full Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_fullStr Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_full_unstemmed Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
title_sort Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
dc.creator.none.fl_str_mv Clemente, C.
Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author Clemente, C.
author_facet Clemente, C.
Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author_role author
author2 Bosch i Genover, Jaume
Rodés, J.
Arroyo, Vicente
Mas Comas, Ana M.
Maragall, S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
topic Insuficiència renal aguda
Cirrosi hepàtica
Hemorràgia gastrointestinal
Endotoxines
Gastritis
Hepatic cirrhosis
Acute renal failure
Gastritis
Gastrointestinal hemorrhage
Endotoxins
description Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.
publishDate 1977
dc.date.none.fl_str_mv 1977
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/18642
url https://hdl.handle.net/2445/18642
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.18.7.556
Gut, 1977, vol. 18, núm. 7, p. 556-560
http://dx.doi.org/10.1136/gut.18.7.556
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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