Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering

Human pluripotent stem cells hold inherent properties, allowing researchers to recapitulate key morphogenetic processes. These characteristics, coupled with bioengineering techniques, have led to the definition of early procedures to derive organ-like cell cultures, the so-called organoids. With reg...

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Detalhes bibliográficos
Autores: Goux Corredera, Iphigénie, Amato, Gaia, Moya Rull, Daniel, Garreta Bahima, Elena, Montserrat Pulido, Núria
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/221742
Acesso em linha:https://hdl.handle.net/2445/221742
Access Level:Acceso aberto
Palavra-chave:Bioenginyeria
Ronyó
Cultius cel·lulars humans
Bioengineering
Kidney
Human cell culture
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spelling Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineeringGoux Corredera, IphigénieAmato, GaiaMoya Rull, DanielGarreta Bahima, ElenaMontserrat Pulido, NúriaBioenginyeriaRonyóCultius cel·lulars humansBioengineeringKidneyHuman cell cultureHuman pluripotent stem cells hold inherent properties, allowing researchers to recapitulate key morphogenetic processes. These characteristics, coupled with bioengineering techniques, have led to the definition of early procedures to derive organ-like cell cultures, the so-called organoids. With regard to kidney organoids, challenges stand ahead, such as the need to enhance cellular composition, maturation, and function to that found in the native organ. To this end, the kidney organoid field has begun to nourish from innovative engineering approaches aiming to gain control on the externally imposed biochemical and biophysical cues. In this review, we first introduce how previous research in kidney development and human pluripotent stem cells has informed the establishment of current kidney organoid procedures. We then discuss recent engineering approaches to guide kidney organoid self-organization, differentiation, and maturation. In addition, we present current strategies to engineer vascularization and promote in vivo–like physiological microenvironments as potential solutions to increase kidney organoid lifespan and functionality. We finally emphasize how working at the cusp of cell mechanics and computational biology will set the ground for successful translational applications of kidney organoids.Elsevier2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/221742Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.kint.2025.01.043Kidney International, 2025, vol. 108, num. 1, p. 38-47https://doi.org/10.1016/j.kint.2025.01.043cc-by (c) International Society of Nephrology, 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2217422026-05-27T06:46:51Z
dc.title.none.fl_str_mv Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
title Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
spellingShingle Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
Goux Corredera, Iphigénie
Bioenginyeria
Ronyó
Cultius cel·lulars humans
Bioengineering
Kidney
Human cell culture
title_short Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
title_full Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
title_fullStr Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
title_full_unstemmed Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
title_sort Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering
dc.creator.none.fl_str_mv Goux Corredera, Iphigénie
Amato, Gaia
Moya Rull, Daniel
Garreta Bahima, Elena
Montserrat Pulido, Núria
author Goux Corredera, Iphigénie
author_facet Goux Corredera, Iphigénie
Amato, Gaia
Moya Rull, Daniel
Garreta Bahima, Elena
Montserrat Pulido, Núria
author_role author
author2 Amato, Gaia
Moya Rull, Daniel
Garreta Bahima, Elena
Montserrat Pulido, Núria
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bioenginyeria
Ronyó
Cultius cel·lulars humans
Bioengineering
Kidney
Human cell culture
topic Bioenginyeria
Ronyó
Cultius cel·lulars humans
Bioengineering
Kidney
Human cell culture
description Human pluripotent stem cells hold inherent properties, allowing researchers to recapitulate key morphogenetic processes. These characteristics, coupled with bioengineering techniques, have led to the definition of early procedures to derive organ-like cell cultures, the so-called organoids. With regard to kidney organoids, challenges stand ahead, such as the need to enhance cellular composition, maturation, and function to that found in the native organ. To this end, the kidney organoid field has begun to nourish from innovative engineering approaches aiming to gain control on the externally imposed biochemical and biophysical cues. In this review, we first introduce how previous research in kidney development and human pluripotent stem cells has informed the establishment of current kidney organoid procedures. We then discuss recent engineering approaches to guide kidney organoid self-organization, differentiation, and maturation. In addition, we present current strategies to engineer vascularization and promote in vivo–like physiological microenvironments as potential solutions to increase kidney organoid lifespan and functionality. We finally emphasize how working at the cusp of cell mechanics and computational biology will set the ground for successful translational applications of kidney organoids.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221742
url https://hdl.handle.net/2445/221742
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.kint.2025.01.043
Kidney International, 2025, vol. 108, num. 1, p. 38-47
https://doi.org/10.1016/j.kint.2025.01.043
dc.rights.none.fl_str_mv cc-by (c) International Society of Nephrology, 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) International Society of Nephrology, 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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