The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive im...

Descripción completa

Detalles Bibliográficos
Autores: Bos, I, Vos, SJ, Frolich, L, Kornhuber, J, Wiltfang, J, Maier, W, Peters, O, Ruther, E, Engelborghs, S, Niemantsverdriet, E, De Roeck, EE, Tsolaki, M, Freund-Levim, Y, Johannsen, P, Vandenberghe, R, Lleo, A, Alcolea, D, Frisoni, GB, Galluzzi, S, Nobili, F, Morbelli, S, Drzezga, A, Didic, M, van Berckel, BN, Salmon, E, Bastin, C, Dauby, S, Santana, I, Baldeiras, I, de Mendonca, A, Silva, D, Wallin, A, Nordlund, A, Coloma, PM, Wientzek, A, Alexander, M, Novak, GP, Gordon, MF, Wallin, AK, Hampel, H, Soininen, H, Herukka, SK, Scheltens, P, Verhey, FR, Visser, PJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p14161
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14161
https://cris.maastrichtuniversity.nl/en/publications/the-frequency-and-influence-of-dementia-risk-factors-in-prodromal
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Risk factors
IWG-2 criteria
NIA-AA criteria
Biomarkers
Prognosis
Descripción
Sumario:We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.

Similares en LA Referencia