Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain

For many years Staphylococcus aureus has been recognized as an important human pathogen. In this study, the surfacome and exoproteome of a clinical sample of MRSA was analyzed. The C2355 strain, previously typed as ST398 and spa-t011 and showing a phenotype of multiresistance to antibiotics, has sev...

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Autores: Monteiro, R., Hébraud, M., Chafsey, I., Chambon, C., Viala, D., Torres, C. [0000-0003-3709-1690], Poeta, P. [0000-0003-0925-689X], Igrejas, G. [0000-0002-6365-0735]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de La Rioja (UR)
Repositorio:RIUR. Repositorio Institucional de la Universidad de La Rioja
OAI Identifier:oai:portal.dialnet.es:doc/5bbc6811b750603269e801db
Acceso en línea:https://investigacion.unirioja.es/documentos/5bbc6811b750603269e801db
Access Level:acceso abierto
Palabra clave:Antibiotic resistance
Exoproteome
MRSA
Proteomics
Surfaceome
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spelling Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strainMonteiro, R.Hébraud, M.Chafsey, I.Chambon, C.Viala, D.Torres, C. [0000-0003-3709-1690]Poeta, P. [0000-0003-0925-689X]Igrejas, G. [0000-0002-6365-0735]Antibiotic resistanceExoproteomeMRSAProteomicsSurfaceomeFor many years Staphylococcus aureus has been recognized as an important human pathogen. In this study, the surfacome and exoproteome of a clinical sample of MRSA was analyzed. The C2355 strain, previously typed as ST398 and spa-t011 and showing a phenotype of multiresistance to antibiotics, has several resistance genes. Using shotgun proteomics and bioinformatics tools, 236 proteins were identified in the surfaceome and 99 proteins in the exoproteome. Although many of these proteins are related to basic cell functions, some are related to virulence and pathogenicity like catalase and isdA, main actors in S. aureus infection, and others are related to antibiotic action or eventually resistance like penicillin binding protein, a cell-wall protein. Studying the proteomes of different subcellular compartments should improve our understanding of this pathogen, a microorganism with several mechanisms of resistance and pathogenicity, and provide valuable data for bioinformatics databases. © 2015 The Authors.2015info:eu-repo/semantics/articleSubtype: Articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://investigacion.unirioja.es/documentos/5bbc6811b750603269e801dbreponame:RIUR. Repositorio Institucional de la Universidad de La Riojainstname:Universidad de La Rioja (UR)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/J.BBREP.2015.07.004info:eu-repo/semantics/altIdentifier/pissn/2405-5808Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain, 2015, vol. 3, pág. 7-13info:eu-repo/semantics/openAccessoai:portal.dialnet.es:doc/5bbc6811b750603269e801db2026-06-14T12:47:17Z
dc.title.none.fl_str_mv Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
title Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
spellingShingle Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
Monteiro, R.
Antibiotic resistance
Exoproteome
MRSA
Proteomics
Surfaceome
title_short Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
title_full Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
title_fullStr Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
title_full_unstemmed Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
title_sort Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain
dc.creator.none.fl_str_mv Monteiro, R.
Hébraud, M.
Chafsey, I.
Chambon, C.
Viala, D.
Torres, C. [0000-0003-3709-1690]
Poeta, P. [0000-0003-0925-689X]
Igrejas, G. [0000-0002-6365-0735]
author Monteiro, R.
author_facet Monteiro, R.
Hébraud, M.
Chafsey, I.
Chambon, C.
Viala, D.
Torres, C. [0000-0003-3709-1690]
Poeta, P. [0000-0003-0925-689X]
Igrejas, G. [0000-0002-6365-0735]
author_role author
author2 Hébraud, M.
Chafsey, I.
Chambon, C.
Viala, D.
Torres, C. [0000-0003-3709-1690]
Poeta, P. [0000-0003-0925-689X]
Igrejas, G. [0000-0002-6365-0735]
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antibiotic resistance
Exoproteome
MRSA
Proteomics
Surfaceome
topic Antibiotic resistance
Exoproteome
MRSA
Proteomics
Surfaceome
description For many years Staphylococcus aureus has been recognized as an important human pathogen. In this study, the surfacome and exoproteome of a clinical sample of MRSA was analyzed. The C2355 strain, previously typed as ST398 and spa-t011 and showing a phenotype of multiresistance to antibiotics, has several resistance genes. Using shotgun proteomics and bioinformatics tools, 236 proteins were identified in the surfaceome and 99 proteins in the exoproteome. Although many of these proteins are related to basic cell functions, some are related to virulence and pathogenicity like catalase and isdA, main actors in S. aureus infection, and others are related to antibiotic action or eventually resistance like penicillin binding protein, a cell-wall protein. Studying the proteomes of different subcellular compartments should improve our understanding of this pathogen, a microorganism with several mechanisms of resistance and pathogenicity, and provide valuable data for bioinformatics databases. © 2015 The Authors.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
Subtype: Article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://investigacion.unirioja.es/documentos/5bbc6811b750603269e801db
url https://investigacion.unirioja.es/documentos/5bbc6811b750603269e801db
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/J.BBREP.2015.07.004
info:eu-repo/semantics/altIdentifier/pissn/2405-5808
Surfaceome and exoproteome of a clinical sequence type 398 methicillin resistant Staphylococcus aureus strain, 2015, vol. 3, pág. 7-13
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUR. Repositorio Institucional de la Universidad de La Rioja
instname:Universidad de La Rioja (UR)
instname_str Universidad de La Rioja (UR)
reponame_str RIUR. Repositorio Institucional de la Universidad de La Rioja
collection RIUR. Repositorio Institucional de la Universidad de La Rioja
repository.name.fl_str_mv
repository.mail.fl_str_mv
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