Hormonal Regulation of chicken intestinal NHE and SGLT-1 activities
The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na/Hexchange (NHE) and Na-sugar cotransport (SGLT-1) activi-ties have been investigated using brush-border membrane ves-icles isolated from Hubbard chicken small and large intestines, and they were compared with those induced b...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión enviada para evaluación y publicación |
| Fecha de publicación: | 2001 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/32603 |
| Acceso en línea: | http://hdl.handle.net/11441/32603 |
| Access Level: | acceso abierto |
| Palabra clave: | low-Na+ diet aldosterone arginine vasotocin brush-border membrane vesicle sodium/hydrogen exchange |
| Sumario: | The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na/Hexchange (NHE) and Na-sugar cotransport (SGLT-1) activi-ties have been investigated using brush-border membrane ves-icles isolated from Hubbard chicken small and large intestines, and they were compared with those induced by either Nadepletion or dehydration. Na depletion was induced by feeding the chickens with either a low- or a high-Na diet for either 0.5, 1, 2, 4, or 8 days. Ileal and colonic NHE2 activity increased with the duration of the Na depletion, whereas that of intestinal SGLT-1 decreased, reaching a plateau after 2 days of treat-ment. Three-hour incubation of the intestine with aldosterone produced the same effects on NHE activity as does Na deple-tion, without altering SGLT-1 activity. However, 3-h incubation of the intestine with AVT increased intestinal SGLT-1 activity, without affecting intestinal NHE activity. It is concluded that aldosterone regulates apical ileal and colonic NHE2 activity, whereas that of SGLT-1 is regulated by AVT. |
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