Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study

17 pages, 10 figures, 2 tables.-- Issue title: "Issue in Honor of Prof. António M. d’A. Rocha Gonçalves".

Detalles Bibliográficos
Autores: Almeida, Joao A. S., Morán, María del Carmen, Infante, María Rosa, Pais, Alberto A. C. C.
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/23176
Acceso en línea:http://hdl.handle.net/10261/23176
Access Level:acceso abierto
Palabra clave:Arginine-based cationic surfactants
DPPC liposomes
Membrane organization
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spelling Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation studyAlmeida, Joao A. S.Morán, María del CarmenInfante, María RosaPais, Alberto A. C. C.Arginine-based cationic surfactantsDPPC liposomesMembrane organization17 pages, 10 figures, 2 tables.-- Issue title: "Issue in Honor of Prof. António M. d’A. Rocha Gonçalves".The effect of two arginine-based cationic surfactants, arginine N-lauroyl amide dihydrochloride and arginine O-lauroyl ester dihydrochloride, upon dipalmitoylphosphatidylcholine liposomes, is addressed in this work. Some aspects concerning the synthesis of these surfactants are also presented in some detail. Differential scanning calorimetry, as well as fluorescence anisotropy using several probes, is used to assess the relative effects on the lipid model membranes. In spite of the structural similarity among these molecules, which differ only by the group that connects the polar head to the tail, experimental results suggest differences in their behavior. Molecular dynamics simulation provides significant insight into the molecular mechanism that governs this interaction. A rationale is provided in terms of lipid-surfactant hydrogen bonding and the consequent positioning of the surfactant molecule within the bilayer.J. A. S. A. gratefully acknowledges PhD grant SFRH/BD/31064/2006, Fundação para a Ciência e Tecnologia. The authors kindly acknowledge Prof. A. S. Jurado for the use of DSC and fluorescence anisotropy equipments.Peer reviewedArkat USA201020102009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501434080 bytesapplication/pdfhttp://hdl.handle.net/10261/23176reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléswww.arkat-usa.org/get-file/29234info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/231762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
title Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
spellingShingle Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
Almeida, Joao A. S.
Arginine-based cationic surfactants
DPPC liposomes
Membrane organization
title_short Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
title_full Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
title_fullStr Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
title_full_unstemmed Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
title_sort Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study
dc.creator.none.fl_str_mv Almeida, Joao A. S.
Morán, María del Carmen
Infante, María Rosa
Pais, Alberto A. C. C.
author Almeida, Joao A. S.
author_facet Almeida, Joao A. S.
Morán, María del Carmen
Infante, María Rosa
Pais, Alberto A. C. C.
author_role author
author2 Morán, María del Carmen
Infante, María Rosa
Pais, Alberto A. C. C.
author2_role author
author
author
dc.subject.none.fl_str_mv Arginine-based cationic surfactants
DPPC liposomes
Membrane organization
topic Arginine-based cationic surfactants
DPPC liposomes
Membrane organization
description 17 pages, 10 figures, 2 tables.-- Issue title: "Issue in Honor of Prof. António M. d’A. Rocha Gonçalves".
publishDate 2009
dc.date.none.fl_str_mv 2009
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/23176
url http://hdl.handle.net/10261/23176
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv www.arkat-usa.org/get-file/29234
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 434080 bytes
application/pdf
dc.publisher.none.fl_str_mv Arkat USA
publisher.none.fl_str_mv Arkat USA
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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