Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis

Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody ha...

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Autores: Consuegra-Fernández, M, Julià, M, Martínez-Florensa, M, Aranda, F, Català, C, Armiger-Borràs, N, Arias, MT, Santiago, F, Guilabert, A, Esteve, A, Muñoz, C, Ferrándiz, C, Carrascosa, JM, Pedrosa, E, Romaní, J, Alsina, M, Mascaró-Galy, JM, Lozano, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5935
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/5935
Access Level:acceso abierto
Palabra clave:ALCAM
CD5
CD6
lymphocyte
psoriasis
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spelling Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasisConsuegra-Fernández, MJulià, MMartínez-Florensa, MAranda, FCatalà, CArmiger-Borràs, NArias, MTSantiago, FGuilabert, AEsteve, AMuñoz, CFerrándiz, CCarrascosa, JMPedrosa, ERomaní, JAlsina, MMascaró-Galy, JMLozano, FALCAMCD5CD6lymphocytepsoriasisPsoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A. Thus, isolated CD4(+)CD62L(+) T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 polarization. Second, a statistically significant association between CD6 single-nucleotide polymorphisms (rs17824933, rs11230563 and rs12360861) and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona. Taken together, these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels.CHIN SOCIETY IMMUNOLOGY2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5935Cellular & Molecular ImmunologyISSN: 16727681ISSNe: 20420226reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p59352026-06-21T15:30:37Z
dc.title.none.fl_str_mv Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
title Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
spellingShingle Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
Consuegra-Fernández, M
ALCAM
CD5
CD6
lymphocyte
psoriasis
title_short Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
title_full Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
title_fullStr Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
title_full_unstemmed Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
title_sort Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis
dc.creator.none.fl_str_mv Consuegra-Fernández, M
Julià, M
Martínez-Florensa, M
Aranda, F
Català, C
Armiger-Borràs, N
Arias, MT
Santiago, F
Guilabert, A
Esteve, A
Muñoz, C
Ferrándiz, C
Carrascosa, JM
Pedrosa, E
Romaní, J
Alsina, M
Mascaró-Galy, JM
Lozano, F
author Consuegra-Fernández, M
author_facet Consuegra-Fernández, M
Julià, M
Martínez-Florensa, M
Aranda, F
Català, C
Armiger-Borràs, N
Arias, MT
Santiago, F
Guilabert, A
Esteve, A
Muñoz, C
Ferrándiz, C
Carrascosa, JM
Pedrosa, E
Romaní, J
Alsina, M
Mascaró-Galy, JM
Lozano, F
author_role author
author2 Julià, M
Martínez-Florensa, M
Aranda, F
Català, C
Armiger-Borràs, N
Arias, MT
Santiago, F
Guilabert, A
Esteve, A
Muñoz, C
Ferrándiz, C
Carrascosa, JM
Pedrosa, E
Romaní, J
Alsina, M
Mascaró-Galy, JM
Lozano, F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALCAM
CD5
CD6
lymphocyte
psoriasis
topic ALCAM
CD5
CD6
lymphocyte
psoriasis
description Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A. Thus, isolated CD4(+)CD62L(+) T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 polarization. Second, a statistically significant association between CD6 single-nucleotide polymorphisms (rs17824933, rs11230563 and rs12360861) and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona. Taken together, these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5935
url https://i3pt.portalinvestigacion.com/publicaciones/5935
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CHIN SOCIETY IMMUNOLOGY
publisher.none.fl_str_mv CHIN SOCIETY IMMUNOLOGY
dc.source.none.fl_str_mv Cellular & Molecular Immunology
ISSN: 16727681
ISSNe: 20420226
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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