No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach

Breast cancer (BC) is globally the most frequent cancer in women. Adherence to endocrine therapy (ET) in hormone-receptor-positive BC patients is active and voluntary for the first five years after diagnosis. This study examines the impact of adherence to ET on 10-year excess mortality (EM) in patie...

Descripción completa

Detalles Bibliográficos
Autores: Clèries Soler, Ramon, Buxó, Maria, Vilardell, Mireia, Ameijide, Alberto, Martínez, José Miguel, Font, Rebeca, Marcos Gragera, Rafael, Puigdemont, Montserrat, Viñas, Gemma, Carulla, Marià, Espinàs Piñol, Josep Alfons, Galceran, Jaume, Izquierdo i Font, Àngel Xavier, Borràs, Josep Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185037
Acceso en línea:https://hdl.handle.net/2445/185037
Access Level:acceso abierto
Palabra clave:Càncer de mama
Endocrinologia
Breast cancer
Endocrinology
id ES_32db9dbbcd2d9d129b093e6417a56ac8
oai_identifier_str oai:diposit.ub.edu:2445/185037
network_acronym_str ES
network_name_str España
repository_id_str
spelling No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling ApproachClèries Soler, RamonBuxó, MariaVilardell, MireiaAmeijide, AlbertoMartínez, José MiguelFont, RebecaMarcos Gragera, RafaelPuigdemont, MontserratViñas, GemmaCarulla, MariàEspinàs Piñol, Josep AlfonsGalceran, JaumeIzquierdo i Font, Àngel XavierBorràs, Josep MariaCàncer de mamaEndocrinologiaBreast cancerEndocrinologyBreast cancer (BC) is globally the most frequent cancer in women. Adherence to endocrine therapy (ET) in hormone-receptor-positive BC patients is active and voluntary for the first five years after diagnosis. This study examines the impact of adherence to ET on 10-year excess mortality (EM) in patients diagnosed with Stages I to III BC (N = 2297). Since sample size is an issue for estimating age- and stage-specific survival indicators, we developed a method, ComSynSurData, for generating a large synthetic dataset (SynD) through probabilistic graphical modeling of the original cohort. We derived population-based survival indicators using a Bayesian relative survival model fitted to the SynD. Our modeling showed that hormone-receptor-positive BC patients diagnosed beyond 49 years of age at Stage I or beyond 59 years at Stage II do not have 10-year EM if they follow the prescribed ET regimen. This result calls for developing interventions to promote adherence to ET in patients with hormone receptor-positive BC and in turn improving cancer survival. The presented methodology here demonstrates the potential use of probabilistic graphical modeling for generating reliable synthetic datasets for validating population-based survival indicators when sample size is an issue.MDPI AG2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185037Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijerph19063605International Journal of Environmental Research and Public Health, 2022, vol. 19, num. 6https://doi.org/10.3390/ijerph19063605cc by (c) Clèries Soler, Ramon et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1850372026-05-27T06:46:51Z
dc.title.none.fl_str_mv No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
title No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
spellingShingle No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
Clèries Soler, Ramon
Càncer de mama
Endocrinologia
Breast cancer
Endocrinology
title_short No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
title_full No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
title_fullStr No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
title_full_unstemmed No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
title_sort No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach
dc.creator.none.fl_str_mv Clèries Soler, Ramon
Buxó, Maria
Vilardell, Mireia
Ameijide, Alberto
Martínez, José Miguel
Font, Rebeca
Marcos Gragera, Rafael
Puigdemont, Montserrat
Viñas, Gemma
Carulla, Marià
Espinàs Piñol, Josep Alfons
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
Borràs, Josep Maria
author Clèries Soler, Ramon
author_facet Clèries Soler, Ramon
Buxó, Maria
Vilardell, Mireia
Ameijide, Alberto
Martínez, José Miguel
Font, Rebeca
Marcos Gragera, Rafael
Puigdemont, Montserrat
Viñas, Gemma
Carulla, Marià
Espinàs Piñol, Josep Alfons
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
Borràs, Josep Maria
author_role author
author2 Buxó, Maria
Vilardell, Mireia
Ameijide, Alberto
Martínez, José Miguel
Font, Rebeca
Marcos Gragera, Rafael
Puigdemont, Montserrat
Viñas, Gemma
Carulla, Marià
Espinàs Piñol, Josep Alfons
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
Borràs, Josep Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Endocrinologia
Breast cancer
Endocrinology
topic Càncer de mama
Endocrinologia
Breast cancer
Endocrinology
description Breast cancer (BC) is globally the most frequent cancer in women. Adherence to endocrine therapy (ET) in hormone-receptor-positive BC patients is active and voluntary for the first five years after diagnosis. This study examines the impact of adherence to ET on 10-year excess mortality (EM) in patients diagnosed with Stages I to III BC (N = 2297). Since sample size is an issue for estimating age- and stage-specific survival indicators, we developed a method, ComSynSurData, for generating a large synthetic dataset (SynD) through probabilistic graphical modeling of the original cohort. We derived population-based survival indicators using a Bayesian relative survival model fitted to the SynD. Our modeling showed that hormone-receptor-positive BC patients diagnosed beyond 49 years of age at Stage I or beyond 59 years at Stage II do not have 10-year EM if they follow the prescribed ET regimen. This result calls for developing interventions to promote adherence to ET in patients with hormone receptor-positive BC and in turn improving cancer survival. The presented methodology here demonstrates the potential use of probabilistic graphical modeling for generating reliable synthetic datasets for validating population-based survival indicators when sample size is an issue.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185037
url https://hdl.handle.net/2445/185037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijerph19063605
International Journal of Environmental Research and Public Health, 2022, vol. 19, num. 6
https://doi.org/10.3390/ijerph19063605
dc.rights.none.fl_str_mv cc by (c) Clèries Soler, Ramon et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Clèries Soler, Ramon et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405701619580928
score 15.301629

Similares en LA Referencia