The Kappa Opioid Receptor and the Sleep of Reason

The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly select...

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Autores: Oña, Genís|||0000-0003-2741-2876, Sampedro, Frederic|||0000-0002-3933-1355, Romero, Sergio, Valle, Marta|||0000-0002-3515-251X, Camacho, Valle|||0000-0003-0748-0847, Migliorelli, Carolina|||0000-0003-2781-8841, Mañanas, Miguel Ángel, Antonijoan Arbós, Rosa Ma (Rosa María)|||0000-0002-7099-5125, Puntes, Montserrat, Coimbra, Jimena, Ballester, Maria Rosa|||0000-0002-0472-9558, Garrido, Maite, Riba, Jordi|||0000-0002-9375-8421
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:284376
Acesso em linha:https://ddd.uab.cat/record/284376
https://dx.doi.org/urn:doi:10.1093/ijnp/pyab063
Access Level:Acceso aberto
Palavra-chave:EEG
Hallucinogens
Kappa opioid receptor
Opioids
Salvinorin-a
SPECT
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spelling The Kappa Opioid Receptor and the Sleep of ReasonCortico-Subcortical Imbalance Following Salvinorin-AOña, Genís|||0000-0003-2741-2876Sampedro, Frederic|||0000-0002-3933-1355Romero, SergioValle, Marta|||0000-0002-3515-251XCamacho, Valle|||0000-0003-0748-0847Migliorelli, Carolina|||0000-0003-2781-8841Mañanas, Miguel ÁngelAntonijoan Arbós, Rosa Ma (Rosa María)|||0000-0002-7099-5125Puntes, MontserratCoimbra, JimenaBallester, Maria Rosa|||0000-0002-0472-9558Garrido, MaiteRiba, Jordi|||0000-0002-9375-8421EEGHallucinogensKappa opioid receptorOpioidsSalvinorin-aSPECTThe mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist. Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported. The study included 2 sub-studies that employed a double-blind, crossover, randomized, placebo-controlled design. The electroencephalography measures showed a marked increase in delta and gamma waves and a decrease in alpha waves while subjects were under the effect of salvinorin-A. Regarding single-photon emission computed tomography measures, significant decreases in regional cerebral blood flow were detected in multiple regions of the frontal, temporal, parietal, and occipital cortices. Significant regional cerebral blood flow increases were observed in some regions of the medial temporal lobe, including the amygdala, the hippocampal gyrus, and the cerebellum. The pattern of subjective effects induced by salvinorin-A was similar to those observed in relation to other psychotomimetic drugs but with an evidently dissociative nature. No dysphoric effects were reported. The salvinorin-A-mediated KOR agonism induced dramatic psychotomimetic effects along with a generalized decrease in cerebral blood flow and electric activity within the cerebral cortex. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/284376https://dx.doi.org/urn:doi:10.1093/ijnp/pyab063reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 DPI2017-83989-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2843762026-06-06T12:50:31Z
dc.title.none.fl_str_mv The Kappa Opioid Receptor and the Sleep of Reason
Cortico-Subcortical Imbalance Following Salvinorin-A
title The Kappa Opioid Receptor and the Sleep of Reason
spellingShingle The Kappa Opioid Receptor and the Sleep of Reason
Oña, Genís|||0000-0003-2741-2876
EEG
Hallucinogens
Kappa opioid receptor
Opioids
Salvinorin-a
SPECT
title_short The Kappa Opioid Receptor and the Sleep of Reason
title_full The Kappa Opioid Receptor and the Sleep of Reason
title_fullStr The Kappa Opioid Receptor and the Sleep of Reason
title_full_unstemmed The Kappa Opioid Receptor and the Sleep of Reason
title_sort The Kappa Opioid Receptor and the Sleep of Reason
dc.creator.none.fl_str_mv Oña, Genís|||0000-0003-2741-2876
Sampedro, Frederic|||0000-0002-3933-1355
Romero, Sergio
Valle, Marta|||0000-0002-3515-251X
Camacho, Valle|||0000-0003-0748-0847
Migliorelli, Carolina|||0000-0003-2781-8841
Mañanas, Miguel Ángel
Antonijoan Arbós, Rosa Ma (Rosa María)|||0000-0002-7099-5125
Puntes, Montserrat
Coimbra, Jimena
Ballester, Maria Rosa|||0000-0002-0472-9558
Garrido, Maite
Riba, Jordi|||0000-0002-9375-8421
author Oña, Genís|||0000-0003-2741-2876
author_facet Oña, Genís|||0000-0003-2741-2876
Sampedro, Frederic|||0000-0002-3933-1355
Romero, Sergio
Valle, Marta|||0000-0002-3515-251X
Camacho, Valle|||0000-0003-0748-0847
Migliorelli, Carolina|||0000-0003-2781-8841
Mañanas, Miguel Ángel
Antonijoan Arbós, Rosa Ma (Rosa María)|||0000-0002-7099-5125
Puntes, Montserrat
Coimbra, Jimena
Ballester, Maria Rosa|||0000-0002-0472-9558
Garrido, Maite
Riba, Jordi|||0000-0002-9375-8421
author_role author
author2 Sampedro, Frederic|||0000-0002-3933-1355
Romero, Sergio
Valle, Marta|||0000-0002-3515-251X
Camacho, Valle|||0000-0003-0748-0847
Migliorelli, Carolina|||0000-0003-2781-8841
Mañanas, Miguel Ángel
Antonijoan Arbós, Rosa Ma (Rosa María)|||0000-0002-7099-5125
Puntes, Montserrat
Coimbra, Jimena
Ballester, Maria Rosa|||0000-0002-0472-9558
Garrido, Maite
Riba, Jordi|||0000-0002-9375-8421
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EEG
Hallucinogens
Kappa opioid receptor
Opioids
Salvinorin-a
SPECT
topic EEG
Hallucinogens
Kappa opioid receptor
Opioids
Salvinorin-a
SPECT
description The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist. Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported. The study included 2 sub-studies that employed a double-blind, crossover, randomized, placebo-controlled design. The electroencephalography measures showed a marked increase in delta and gamma waves and a decrease in alpha waves while subjects were under the effect of salvinorin-A. Regarding single-photon emission computed tomography measures, significant decreases in regional cerebral blood flow were detected in multiple regions of the frontal, temporal, parietal, and occipital cortices. Significant regional cerebral blood flow increases were observed in some regions of the medial temporal lobe, including the amygdala, the hippocampal gyrus, and the cerebellum. The pattern of subjective effects induced by salvinorin-A was similar to those observed in relation to other psychotomimetic drugs but with an evidently dissociative nature. No dysphoric effects were reported. The salvinorin-A-mediated KOR agonism induced dramatic psychotomimetic effects along with a generalized decrease in cerebral blood flow and electric activity within the cerebral cortex.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/284376
https://dx.doi.org/urn:doi:10.1093/ijnp/pyab063
url https://ddd.uab.cat/record/284376
https://dx.doi.org/urn:doi:10.1093/ijnp/pyab063
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 DPI2017-83989-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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