Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening

The SAMANTA questionnaire and the Heavy Menstrual Bleeding-Visual Analog Scale (HMB-VAS) tool have been validated for diagnosing heavy menstrual bleeding (HMB). We assessed their value for screening iron deficiency (ID). Post hoc analysis of the prospective, randomized, phase 4 Cooper and Levonorges...

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Autores: Perelló Capo, Josep|||0000-0001-9914-9312, Estadella Tarriel, Josep|||0000-0001-7140-3091, Gich, Ignasi|||0000-0003-3975-6588, Llurba, Elisa|||0000-0003-4048-6407, Calaf Alsina, Joaquim|||0000-0002-2407-7884
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::bea814ec3874d5f434feb6603cd5f8c2
Acesso em linha:https://ddd.uab.cat/record/328075
https://dx.doi.org/urn:doi:10.1177/26884844251382731
Access Level:acceso abierto
Palavra-chave:Heavy menstrual bleeding
Iron deficiency
Quality of life
Screening
Ferritin
Performance
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spelling Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency ScreeningAn Exploratory Analysis from the COLIBRI StudyPerelló Capo, Josep|||0000-0001-9914-9312Estadella Tarriel, Josep|||0000-0001-7140-3091Gich, Ignasi|||0000-0003-3975-6588Llurba, Elisa|||0000-0003-4048-6407Calaf Alsina, Joaquim|||0000-0002-2407-7884Heavy menstrual bleedingIron deficiencyQuality of lifeScreeningFerritinPerformanceThe SAMANTA questionnaire and the Heavy Menstrual Bleeding-Visual Analog Scale (HMB-VAS) tool have been validated for diagnosing heavy menstrual bleeding (HMB). We assessed their value for screening iron deficiency (ID). Post hoc analysis of the prospective, randomized, phase 4 Cooper and Levonorgestrel Intrauterine Device (IUD) Barcelona Research Iniciative (COLIBRI) study, which assessed the bleeding profile of two intrauterine devices. We used information collected during the last follow-up visit (month 36): sociodemographics, hemoglobin/ferritin levels, SAMANTA questionnaire, HMB-VAS tool, and EuroQoL five-dimension five-level scores. The primary outcome was the accuracy of these diagnostic tools in identifying ID. We also assessed their relationship with EQ-5D-5L. We analyzed information from 57 women, 18 (31.6%) and 14 (24.6%) with HMB according to the SAMANTA questionnaire and the HMB-VAS tool, respectively. Ferritin levels showed better inverse correlation than hemoglobin with these HMB diagnostic tools' scores: r = -0.539 and r = -0.557, respectively, both p. < 0.001. In women with HMB according to these tools, the ferritin threshold showing the best sensitivity and specificity to identify ID was <10 ng/mL with the SAMANTA questionnaire (71.4% [Confidence Interval (CI) 95% 35.2-93.5] and 78% [CI 95% 65.2-87.7], respectively) and <15 ng/mL for the HMB-VAS tool (58.3% [CI 95% 31.2-87.7] and 82.2% [CI 95% 69.2-91.2], respectively). Only the EQ-VAS scores correlated inversely with the scores of both HMB diagnostic tools (r = -0.308, p = 0.02, and r = -0.294, p = 0.026, respectively). Conclusions: This exploratory analysis shows the SAMANTA questionnaire's good potential for ID screening. The scores of both HMB diagnostic tools correlated with the EQ-VAS, demonstrating their value in capturing the HMB impact on quality of life.Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328075https://dx.doi.org/urn:doi:10.1177/26884844251382731reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::bea814ec3874d5f434feb6603cd5f8c22026-06-06T12:50:31Z
dc.title.none.fl_str_mv Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
An Exploratory Analysis from the COLIBRI Study
title Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
spellingShingle Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
Perelló Capo, Josep|||0000-0001-9914-9312
Heavy menstrual bleeding
Iron deficiency
Quality of life
Screening
Ferritin
Performance
title_short Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
title_full Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
title_fullStr Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
title_full_unstemmed Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
title_sort Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening
dc.creator.none.fl_str_mv Perelló Capo, Josep|||0000-0001-9914-9312
Estadella Tarriel, Josep|||0000-0001-7140-3091
Gich, Ignasi|||0000-0003-3975-6588
Llurba, Elisa|||0000-0003-4048-6407
Calaf Alsina, Joaquim|||0000-0002-2407-7884
author Perelló Capo, Josep|||0000-0001-9914-9312
author_facet Perelló Capo, Josep|||0000-0001-9914-9312
Estadella Tarriel, Josep|||0000-0001-7140-3091
Gich, Ignasi|||0000-0003-3975-6588
Llurba, Elisa|||0000-0003-4048-6407
Calaf Alsina, Joaquim|||0000-0002-2407-7884
author_role author
author2 Estadella Tarriel, Josep|||0000-0001-7140-3091
Gich, Ignasi|||0000-0003-3975-6588
Llurba, Elisa|||0000-0003-4048-6407
Calaf Alsina, Joaquim|||0000-0002-2407-7884
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia
dc.subject.none.fl_str_mv Heavy menstrual bleeding
Iron deficiency
Quality of life
Screening
Ferritin
Performance
topic Heavy menstrual bleeding
Iron deficiency
Quality of life
Screening
Ferritin
Performance
description The SAMANTA questionnaire and the Heavy Menstrual Bleeding-Visual Analog Scale (HMB-VAS) tool have been validated for diagnosing heavy menstrual bleeding (HMB). We assessed their value for screening iron deficiency (ID). Post hoc analysis of the prospective, randomized, phase 4 Cooper and Levonorgestrel Intrauterine Device (IUD) Barcelona Research Iniciative (COLIBRI) study, which assessed the bleeding profile of two intrauterine devices. We used information collected during the last follow-up visit (month 36): sociodemographics, hemoglobin/ferritin levels, SAMANTA questionnaire, HMB-VAS tool, and EuroQoL five-dimension five-level scores. The primary outcome was the accuracy of these diagnostic tools in identifying ID. We also assessed their relationship with EQ-5D-5L. We analyzed information from 57 women, 18 (31.6%) and 14 (24.6%) with HMB according to the SAMANTA questionnaire and the HMB-VAS tool, respectively. Ferritin levels showed better inverse correlation than hemoglobin with these HMB diagnostic tools' scores: r = -0.539 and r = -0.557, respectively, both p. < 0.001. In women with HMB according to these tools, the ferritin threshold showing the best sensitivity and specificity to identify ID was <10 ng/mL with the SAMANTA questionnaire (71.4% [Confidence Interval (CI) 95% 35.2-93.5] and 78% [CI 95% 65.2-87.7], respectively) and <15 ng/mL for the HMB-VAS tool (58.3% [CI 95% 31.2-87.7] and 82.2% [CI 95% 69.2-91.2], respectively). Only the EQ-VAS scores correlated inversely with the scores of both HMB diagnostic tools (r = -0.308, p = 0.02, and r = -0.294, p = 0.026, respectively). Conclusions: This exploratory analysis shows the SAMANTA questionnaire's good potential for ID screening. The scores of both HMB diagnostic tools correlated with the EQ-VAS, demonstrating their value in capturing the HMB impact on quality of life.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/328075
https://dx.doi.org/urn:doi:10.1177/26884844251382731
url https://ddd.uab.cat/record/328075
https://dx.doi.org/urn:doi:10.1177/26884844251382731
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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