Circadian Regulation of Adult Stem Cell Homeostasis and Aging

The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent tempo...

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Detalles Bibliográficos
Autores: Aznar Benitah, Salvador, Welz, Patrick Simon
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/177900
Acceso en línea:https://hdl.handle.net/2445/177900
Access Level:acceso abierto
Palabra clave:Cèl·lules mare
Envelliment
Ritmes circadiaris
Stem cells
Aging
Circadian rhythms
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spelling Circadian Regulation of Adult Stem Cell Homeostasis and AgingAznar Benitah, SalvadorWelz, Patrick SimonCèl·lules mareEnvellimentRitmes circadiarisStem cellsAgingCircadian rhythmsThe circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis.Elsevier2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/177900Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.stem.2020.05.002Cell Stem Cell, 2020, Vol.26, num. 6, p. 817-831https://doi.org/10.1016/j.stem.2020.05.002cc by-nc-nd (c) Elsevier, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1779002026-05-27T06:46:51Z
dc.title.none.fl_str_mv Circadian Regulation of Adult Stem Cell Homeostasis and Aging
title Circadian Regulation of Adult Stem Cell Homeostasis and Aging
spellingShingle Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Aznar Benitah, Salvador
Cèl·lules mare
Envelliment
Ritmes circadiaris
Stem cells
Aging
Circadian rhythms
title_short Circadian Regulation of Adult Stem Cell Homeostasis and Aging
title_full Circadian Regulation of Adult Stem Cell Homeostasis and Aging
title_fullStr Circadian Regulation of Adult Stem Cell Homeostasis and Aging
title_full_unstemmed Circadian Regulation of Adult Stem Cell Homeostasis and Aging
title_sort Circadian Regulation of Adult Stem Cell Homeostasis and Aging
dc.creator.none.fl_str_mv Aznar Benitah, Salvador
Welz, Patrick Simon
author Aznar Benitah, Salvador
author_facet Aznar Benitah, Salvador
Welz, Patrick Simon
author_role author
author2 Welz, Patrick Simon
author2_role author
dc.subject.none.fl_str_mv Cèl·lules mare
Envelliment
Ritmes circadiaris
Stem cells
Aging
Circadian rhythms
topic Cèl·lules mare
Envelliment
Ritmes circadiaris
Stem cells
Aging
Circadian rhythms
description The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177900
url https://hdl.handle.net/2445/177900
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.stem.2020.05.002
Cell Stem Cell, 2020, Vol.26, num. 6, p. 817-831
https://doi.org/10.1016/j.stem.2020.05.002
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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