Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

Medical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A pleth...

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Detalles Bibliográficos
Autores: Xicota Vila, Laura, 1987-, Rodríguez-Morató, Jose, 1987-, Dierssen, Mara, Torre Fornell, Rafael de la
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/28231
Acceso en línea:http://hdl.handle.net/10230/28231
http://dx.doi.org/10.2174/1389450116666150825113655
Access Level:acceso abierto
Palabra clave:Alzheimer, Malaltia d&apos
Sistema nerviós -- Degeneració
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spelling Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer DiseaseXicota Vila, Laura, 1987-Rodríguez-Morató, Jose, 1987-Dierssen, MaraTorre Fornell, Rafael de laAlzheimer, Malaltia d&aposSistema nerviós -- DegeneracióMedical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development and progression. So far, there are no pharmacological treatments available and the current medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention due to their interesting biological activities, and more specifically their antioxidant properties. (-)- Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only limited to its antioxidant activity, which may explain its beneficial health effects.This work was supported by grants, donations and agreements from Fondation Jérôme Lejeune (Paris, France), Instituto de Salud Carlos III FEDER, (PI11/00744), MINECO (SAF2010- 19434, MTM2012-38067-C02-01 and SAF2013-49129-C1- R), EU (Era Net Neuron PCIN-2013-060) co-financed by European Regional Development Fund, DIUE de la Generalitat de Catalunya (SGR 2009/1450, SGR 2014/464 SGR 2014/1125). We acknowledge support of the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208.Jose Rodríguez-Morató was supported by a FI-DGR 2013 predoctoral fellowship from the Generalitat de Catalunya.Bentham Science Publishers20172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/28231http://dx.doi.org/10.2174/1389450116666150825113655reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCurrent Drug Targets. 2017;18(2):174-95info:eu-repo/grantAgreement/ES/3PN/SAF2010-19434info:eu-repo/grantAgreement/ES/3PN/MTM2012-38067-C02-01info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C1-Rinfo:eu-repo/grantAgreement/ES/1PE/PCIN-2013-060© Bentham Science Publishers. Article published in Xicota L, Rodriguez-Morato J, Dierssen M, de la Torre R, Current Drug Targets. 2017;18(2):174-195. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/10.2174/1389450116666150825113655info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/282312026-06-12T07:21:37Z
dc.title.none.fl_str_mv Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
title Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
spellingShingle Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
Xicota Vila, Laura, 1987-
Alzheimer, Malaltia d&apos
Sistema nerviós -- Degeneració
title_short Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
title_full Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
title_fullStr Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
title_full_unstemmed Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
title_sort Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
dc.creator.none.fl_str_mv Xicota Vila, Laura, 1987-
Rodríguez-Morató, Jose, 1987-
Dierssen, Mara
Torre Fornell, Rafael de la
author Xicota Vila, Laura, 1987-
author_facet Xicota Vila, Laura, 1987-
Rodríguez-Morató, Jose, 1987-
Dierssen, Mara
Torre Fornell, Rafael de la
author_role author
author2 Rodríguez-Morató, Jose, 1987-
Dierssen, Mara
Torre Fornell, Rafael de la
author2_role author
author
author
dc.subject.none.fl_str_mv Alzheimer, Malaltia d&apos

Sistema nerviós -- Degeneració
topic Alzheimer, Malaltia d&apos
Sistema nerviós -- Degeneració
description Medical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development and progression. So far, there are no pharmacological treatments available and the current medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention due to their interesting biological activities, and more specifically their antioxidant properties. (-)- Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only limited to its antioxidant activity, which may explain its beneficial health effects.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/28231
http://dx.doi.org/10.2174/1389450116666150825113655
url http://hdl.handle.net/10230/28231
http://dx.doi.org/10.2174/1389450116666150825113655
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Current Drug Targets. 2017;18(2):174-95
info:eu-repo/grantAgreement/ES/3PN/SAF2010-19434
info:eu-repo/grantAgreement/ES/3PN/MTM2012-38067-C02-01
info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C1-R
info:eu-repo/grantAgreement/ES/1PE/PCIN-2013-060
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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