T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations

Clinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosis

Bibliographic Details
Authors: Boaventura de Oliveira, Mateus, Garcia Vidal, Aran, Vidal Jordana, Angela, Quartana, Davide, Carvajal Junco, René Yeltsin, Auger Acosta, Cristina, Alberich Jordà, Manel, Tintore Subirana, Mar, Rovira Cañellas, Alex, Montalban Gairín, Xavier, Pareto Onghena, Deborah, Sastre Garriga, Jaume
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7862
Online Access:https://hdl.handle.net/11351/7862
http://hdl.handle.net/11351/7862
Access Level:Open access
Keyword:Esclerosi múltiple - Imatgeria
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
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oai_identifier_str oai:recercat.cat:11351/7862
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
spellingShingle T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
Boaventura de Oliveira, Mateus
Esclerosi múltiple - Imatgeria
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
title_short T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_full T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_fullStr T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_full_unstemmed T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
title_sort T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
dc.creator.none.fl_str_mv Boaventura de Oliveira, Mateus
Garcia Vidal, Aran
Vidal Jordana, Angela
Quartana, Davide
Carvajal Junco, René Yeltsin
Auger Acosta, Cristina
Alberich Jordà, Manel
Tintore Subirana, Mar
Rovira Cañellas, Alex
Montalban Gairín, Xavier
Pareto Onghena, Deborah
Sastre Garriga, Jaume
author Boaventura de Oliveira, Mateus
author_facet Boaventura de Oliveira, Mateus
Garcia Vidal, Aran
Vidal Jordana, Angela
Quartana, Davide
Carvajal Junco, René Yeltsin
Auger Acosta, Cristina
Alberich Jordà, Manel
Tintore Subirana, Mar
Rovira Cañellas, Alex
Montalban Gairín, Xavier
Pareto Onghena, Deborah
Sastre Garriga, Jaume
author_role author
author2 Garcia Vidal, Aran
Vidal Jordana, Angela
Quartana, Davide
Carvajal Junco, René Yeltsin
Auger Acosta, Cristina
Alberich Jordà, Manel
Tintore Subirana, Mar
Rovira Cañellas, Alex
Montalban Gairín, Xavier
Pareto Onghena, Deborah
Sastre Garriga, Jaume
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Boaventura M, Sastre-Garriga J, Vidal-Jordana A, Quartana D, Carvajal R, Tintoré M, Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. [Garcia-Vidal A, Auger C, Alberich M, Rovira À, Pareto D] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Esclerosi múltiple - Imatgeria
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
topic Esclerosi múltiple - Imatgeria
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
description Clinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosis
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7862
http://hdl.handle.net/11351/7862
url https://hdl.handle.net/11351/7862
http://hdl.handle.net/11351/7862
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv NeuroImage: Clinical;34
https://doi.org/10.1016/j.nicl.2022.102967
info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00823
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405652607041536
spelling T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associationsBoaventura de Oliveira, MateusGarcia Vidal, AranVidal Jordana, AngelaQuartana, DavideCarvajal Junco, René YeltsinAuger Acosta, CristinaAlberich Jordà, ManelTintore Subirana, MarRovira Cañellas, AlexMontalban Gairín, XavierPareto Onghena, DeborahSastre Garriga, JaumeEsclerosi múltiple - ImatgeriaDISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple SclerosisOther subheadings::Other subheadings::Other subheadings::/diagnostic imagingENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltipleOtros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagenClinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosisSíndrome clínicamente aislado; Imágenes por resonancia magnética; Esclerosis múltipleSíndrome clínicament aïllat; Imatges per ressonància magnètica; Esclerosi múltipleBackground T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce. Objective To describe longitudinal changes in T1-w/T2-w in patients with clinically isolated syndrome (CIS) and multiple sclerosis, and to investigate their clinical associations. Methods T1-w/T2-w images were generated and the mean value obtained in the corresponding lesion, normal-appearing grey (NAGM) and white matter (NAWM) masks. By co-registering baseline to follow-up MRI, evolved lesions were assessed; and by placing the mask of new lesions to the baseline study, the pre-lesional tissue integrity was measured. Results We included 171 CIS patients and 22 established multiple sclerosis patients. In CIS, evolved lesions showed significant T1-w/T2-w increases compared to baseline (+7.6%, P < 0.001). T1-w/T2-w values in new lesions were lower than in pre-lesional tissue (-28.2%, P < 0.001), and pre-lesional tissue was already lower than baseline NAWM (-7.8%, P < 0.001). In CIS at baseline, higher NAGM T1-w/T2-w was associated with multiple sclerosis diagnosis, and longitudinal decreases in NAGM and NAWM T1-w/T2-w were associated with disease activity. In established multiple sclerosis, T1-w/T2-w was inversely correlated with clinical disability and disease duration. Conclusion A decrease in T1-w/T2-w ratio precedes lesion formation. In CIS, higher T1-w/T2-w was associated with multiple sclerosis diagnosis. In established multiple sclerosis, lower T1-w/T2-w values were associated with clinical disability. The possible differential impact of chronic inflammation, iron deposition and demyelination should be considered to interpret these findings.This project was developed as a part of Mateus Boaventura ECTRIMS Clinical Training Fellowship Programme 2018–2019. This study was partially supported by the Project PI18/00823, from the Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III.ElsevierInstitut Català de la Salut[Boaventura M, Sastre-Garriga J, Vidal-Jordana A, Quartana D, Carvajal R, Tintoré M, Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. [Garcia-Vidal A, Auger C, Alberich M, Rovira À, Pareto D] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7862http://hdl.handle.net/11351/7862Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNeuroImage: Clinical;34https://doi.org/10.1016/j.nicl.2022.102967info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00823Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/78622026-05-29T05:05:01Z
score 15,811543

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