Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

Ye, J. (Jin)|||/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938; Calvo-Arnedo, I. (Isabel)|||/items/418daa5a-e5cd-4657-bed3-51d603fa8942; Cenzano-Armendáriz, I. (Itziar)|||/items/aebbf756-8d10-457e-b104-57eccfbf79ae; Vilas, A. (Amaia)|||/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f; Martinez-de-Morentin, X. (Xabier)|||/items/1f92837c-5ac6-4103-9879-95050a60eba9; Lasaga, M. (Miren)|||/items/9e42d289-4d2a-4ec0-93b4-124652c8961b; Alignani, D.O. (Diego Óscar)|||/items/86bf2300-6dd0-46b3-90d9-270da3841ff0; Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5; Viñado, A.C. (Ana C.)|||/items/85f5b700-b72e-49f4-af80-92f4d5c61887; San-Martín-Uriz, P. (Patxi)|||/items/621b7a74-311b-4ff1-b688-53d810e30429; Romero, J.P. (Juan Pablo)|||/items/03616479-3ca5-416f-9f44-f57c64007d00; Quilez-Agreda, D. (Delia)|||/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9; Miñana-Barrios, M. (Marta)|||/items/4190e756-316a-48bc-ad81-9a268c7b2b3a; Sancho-Seuma, J.I. (Juan Ignacio)|||/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38; Todisco, G. (Gabriele)|||/items/e09e40ce-62d3-428d-9311-e418f7e727be; Malcovati, L. (Luca)|||/items/b919b54e-5c36-434f-ba3a-07db91eaeb33; Planell-Picola, N. (Núria)|||/items/48849da1-9b4e-446c-b935-f2d5fd63b280; Saez, B. (Borja)|||/items/990d392a-7b64-40a1-8910-150af15b0f87; Tegner, J. (Jesper)|||/items/5fc25984-3966-49dc-8ebf-48e75a4275a7; Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1; Gomez-Cabrero, D. (David)|||/items/4f78b36e-9b75-4b96-a8ee-27e66595e10f

Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing (scRNA-seq) d...

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Detalles Bibliográficos
Autores:	Ye, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938, Calvo-Arnedo, I. (Isabel)\|\|\|/items/418daa5a-e5cd-4657-bed3-51d603fa8942, Cenzano-Armendáriz, I. (Itziar)\|\|\|/items/aebbf756-8d10-457e-b104-57eccfbf79ae, Vilas, A. (Amaia)\|\|\|/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f, Martinez-de-Morentin, X. (Xabier)\|\|\|/items/1f92837c-5ac6-4103-9879-95050a60eba9, Lasaga, M. (Miren)\|\|\|/items/9e42d289-4d2a-4ec0-93b4-124652c8961b, Alignani, D.O. (Diego Óscar)\|\|\|/items/86bf2300-6dd0-46b3-90d9-270da3841ff0, Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5, Viñado, A.C. (Ana C.)\|\|\|/items/85f5b700-b72e-49f4-af80-92f4d5c61887, San-Martín-Uriz, P. (Patxi)\|\|\|/items/621b7a74-311b-4ff1-b688-53d810e30429, Romero, J.P. (Juan Pablo)\|\|\|/items/03616479-3ca5-416f-9f44-f57c64007d00, Quilez-Agreda, D. (Delia)\|\|\|/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9, Miñana-Barrios, M. (Marta)\|\|\|/items/4190e756-316a-48bc-ad81-9a268c7b2b3a, Sancho-Seuma, J.I. (Juan Ignacio)\|\|\|/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38, Todisco, G. (Gabriele)\|\|\|/items/e09e40ce-62d3-428d-9311-e418f7e727be, Malcovati, L. (Luca)\|\|\|/items/b919b54e-5c36-434f-ba3a-07db91eaeb33, Planell-Picola, N. (Núria)\|\|\|/items/48849da1-9b4e-446c-b935-f2d5fd63b280, Saez, B. (Borja)\|\|\|/items/990d392a-7b64-40a1-8910-150af15b0f87, Tegner, J. (Jesper)\|\|\|/items/5fc25984-3966-49dc-8ebf-48e75a4275a7, Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Gomez-Cabrero, D. (David)\|\|\|/items/4f78b36e-9b75-4b96-a8ee-27e66595e10f
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/116499
Acceso en línea:	https://hdl.handle.net/10171/116499
Access Level:	acceso abierto
Palabra clave:	Biological sciences Omics Stem cells research Transcriptomics

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spelling	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservationYe, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938Calvo-Arnedo, I. (Isabel)\|\|\|/items/418daa5a-e5cd-4657-bed3-51d603fa8942Cenzano-Armendáriz, I. (Itziar)\|\|\|/items/aebbf756-8d10-457e-b104-57eccfbf79aeVilas, A. (Amaia)\|\|\|/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14fMartinez-de-Morentin, X. (Xabier)\|\|\|/items/1f92837c-5ac6-4103-9879-95050a60eba9Lasaga, M. (Miren)\|\|\|/items/9e42d289-4d2a-4ec0-93b4-124652c8961bAlignani, D.O. (Diego Óscar)\|\|\|/items/86bf2300-6dd0-46b3-90d9-270da3841ff0Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5Viñado, A.C. (Ana C.)\|\|\|/items/85f5b700-b72e-49f4-af80-92f4d5c61887San-Martín-Uriz, P. (Patxi)\|\|\|/items/621b7a74-311b-4ff1-b688-53d810e30429Romero, J.P. (Juan Pablo)\|\|\|/items/03616479-3ca5-416f-9f44-f57c64007d00Quilez-Agreda, D. (Delia)\|\|\|/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9Miñana-Barrios, M. (Marta)\|\|\|/items/4190e756-316a-48bc-ad81-9a268c7b2b3aSancho-Seuma, J.I. (Juan Ignacio)\|\|\|/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38Todisco, G. (Gabriele)\|\|\|/items/e09e40ce-62d3-428d-9311-e418f7e727beMalcovati, L. (Luca)\|\|\|/items/b919b54e-5c36-434f-ba3a-07db91eaeb33Planell-Picola, N. (Núria)\|\|\|/items/48849da1-9b4e-446c-b935-f2d5fd63b280Saez, B. (Borja)\|\|\|/items/990d392a-7b64-40a1-8910-150af15b0f87Tegner, J. (Jesper)\|\|\|/items/5fc25984-3966-49dc-8ebf-48e75a4275a7Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Gomez-Cabrero, D. (David)\|\|\|/items/4f78b36e-9b75-4b96-a8ee-27e66595e10fBiological sciencesOmicsStem cells researchTranscriptomicsUnderstanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing (scRNA-seq) datasets. As a result, we robustly identify for the first time 14 intermediate cell states and 11 stages of differentiation in the endothelial and mesenchymal BM compartments, respectively. Our data provide the most comprehensive description to date of the murine HSC-regulatory microenvironment and suggest a higher level of specialization of the cellular circuits than previously anticipated. Furthermore, this deep characterization allows inferring conserved features in human, suggesting that the layers of microenvironmental regulation of hematopoiesis may also be shared between species. Our resource and methodology is a stepping-stone toward a comprehensive cell atlas of the BM microenvironment.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/116499reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1164992026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
title	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
spellingShingle	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation Ye, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938 Biological sciences Omics Stem cells research Transcriptomics
title_short	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
title_full	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
title_fullStr	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
title_full_unstemmed	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
title_sort	Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation
dc.creator.none.fl_str_mv	Ye, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938 Calvo-Arnedo, I. (Isabel)\|\|\|/items/418daa5a-e5cd-4657-bed3-51d603fa8942 Cenzano-Armendáriz, I. (Itziar)\|\|\|/items/aebbf756-8d10-457e-b104-57eccfbf79ae Vilas, A. (Amaia)\|\|\|/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Martinez-de-Morentin, X. (Xabier)\|\|\|/items/1f92837c-5ac6-4103-9879-95050a60eba9 Lasaga, M. (Miren)\|\|\|/items/9e42d289-4d2a-4ec0-93b4-124652c8961b Alignani, D.O. (Diego Óscar)\|\|\|/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Viñado, A.C. (Ana C.)\|\|\|/items/85f5b700-b72e-49f4-af80-92f4d5c61887 San-Martín-Uriz, P. (Patxi)\|\|\|/items/621b7a74-311b-4ff1-b688-53d810e30429 Romero, J.P. (Juan Pablo)\|\|\|/items/03616479-3ca5-416f-9f44-f57c64007d00 Quilez-Agreda, D. (Delia)\|\|\|/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9 Miñana-Barrios, M. (Marta)\|\|\|/items/4190e756-316a-48bc-ad81-9a268c7b2b3a Sancho-Seuma, J.I. (Juan Ignacio)\|\|\|/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38 Todisco, G. (Gabriele)\|\|\|/items/e09e40ce-62d3-428d-9311-e418f7e727be Malcovati, L. (Luca)\|\|\|/items/b919b54e-5c36-434f-ba3a-07db91eaeb33 Planell-Picola, N. (Núria)\|\|\|/items/48849da1-9b4e-446c-b935-f2d5fd63b280 Saez, B. (Borja)\|\|\|/items/990d392a-7b64-40a1-8910-150af15b0f87 Tegner, J. (Jesper)\|\|\|/items/5fc25984-3966-49dc-8ebf-48e75a4275a7 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Gomez-Cabrero, D. (David)\|\|\|/items/4f78b36e-9b75-4b96-a8ee-27e66595e10f
author	Ye, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938
author_facet	Ye, J. (Jin)\|\|\|/items/fb83b05d-df89-4bc1-b5c0-e1a300ea5938 Calvo-Arnedo, I. (Isabel)\|\|\|/items/418daa5a-e5cd-4657-bed3-51d603fa8942 Cenzano-Armendáriz, I. (Itziar)\|\|\|/items/aebbf756-8d10-457e-b104-57eccfbf79ae Vilas, A. (Amaia)\|\|\|/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Martinez-de-Morentin, X. (Xabier)\|\|\|/items/1f92837c-5ac6-4103-9879-95050a60eba9 Lasaga, M. (Miren)\|\|\|/items/9e42d289-4d2a-4ec0-93b4-124652c8961b Alignani, D.O. (Diego Óscar)\|\|\|/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Viñado, A.C. (Ana C.)\|\|\|/items/85f5b700-b72e-49f4-af80-92f4d5c61887 San-Martín-Uriz, P. (Patxi)\|\|\|/items/621b7a74-311b-4ff1-b688-53d810e30429 Romero, J.P. (Juan Pablo)\|\|\|/items/03616479-3ca5-416f-9f44-f57c64007d00 Quilez-Agreda, D. (Delia)\|\|\|/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9 Miñana-Barrios, M. (Marta)\|\|\|/items/4190e756-316a-48bc-ad81-9a268c7b2b3a Sancho-Seuma, J.I. (Juan Ignacio)\|\|\|/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38 Todisco, G. (Gabriele)\|\|\|/items/e09e40ce-62d3-428d-9311-e418f7e727be Malcovati, L. (Luca)\|\|\|/items/b919b54e-5c36-434f-ba3a-07db91eaeb33 Planell-Picola, N. (Núria)\|\|\|/items/48849da1-9b4e-446c-b935-f2d5fd63b280 Saez, B. (Borja)\|\|\|/items/990d392a-7b64-40a1-8910-150af15b0f87 Tegner, J. (Jesper)\|\|\|/items/5fc25984-3966-49dc-8ebf-48e75a4275a7 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Gomez-Cabrero, D. (David)\|\|\|/items/4f78b36e-9b75-4b96-a8ee-27e66595e10f
author_role	author
author2	Calvo-Arnedo, I. (Isabel)\|\|\|/items/418daa5a-e5cd-4657-bed3-51d603fa8942 Cenzano-Armendáriz, I. (Itziar)\|\|\|/items/aebbf756-8d10-457e-b104-57eccfbf79ae Vilas, A. (Amaia)\|\|\|/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Martinez-de-Morentin, X. (Xabier)\|\|\|/items/1f92837c-5ac6-4103-9879-95050a60eba9 Lasaga, M. (Miren)\|\|\|/items/9e42d289-4d2a-4ec0-93b4-124652c8961b Alignani, D.O. (Diego Óscar)\|\|\|/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Paiva, B. (Bruno)\|\|\|/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Viñado, A.C. (Ana C.)\|\|\|/items/85f5b700-b72e-49f4-af80-92f4d5c61887 San-Martín-Uriz, P. (Patxi)\|\|\|/items/621b7a74-311b-4ff1-b688-53d810e30429 Romero, J.P. (Juan Pablo)\|\|\|/items/03616479-3ca5-416f-9f44-f57c64007d00 Quilez-Agreda, D. (Delia)\|\|\|/items/08a102a1-8da4-41eb-bb05-93bbe265a5e9 Miñana-Barrios, M. (Marta)\|\|\|/items/4190e756-316a-48bc-ad81-9a268c7b2b3a Sancho-Seuma, J.I. (Juan Ignacio)\|\|\|/items/212db544-f32a-4cea-b4c7-5a9e2fcaae38 Todisco, G. (Gabriele)\|\|\|/items/e09e40ce-62d3-428d-9311-e418f7e727be Malcovati, L. (Luca)\|\|\|/items/b919b54e-5c36-434f-ba3a-07db91eaeb33 Planell-Picola, N. (Núria)\|\|\|/items/48849da1-9b4e-446c-b935-f2d5fd63b280 Saez, B. (Borja)\|\|\|/items/990d392a-7b64-40a1-8910-150af15b0f87 Tegner, J. (Jesper)\|\|\|/items/5fc25984-3966-49dc-8ebf-48e75a4275a7 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Gomez-Cabrero, D. (David)\|\|\|/items/4f78b36e-9b75-4b96-a8ee-27e66595e10f
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Biological sciences Omics Stem cells research Transcriptomics
topic	Biological sciences Omics Stem cells research Transcriptomics
description	Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing (scRNA-seq) datasets. As a result, we robustly identify for the first time 14 intermediate cell states and 11 stages of differentiation in the endothelial and mesenchymal BM compartments, respectively. Our data provide the most comprehensive description to date of the murine HSC-regulatory microenvironment and suggest a higher level of specialization of the cellular circuits than previously anticipated. Furthermore, this deep characterization allows inferring conserved features in human, suggesting that the layers of microenvironmental regulation of hematopoiesis may also be shared between species. Our resource and methodology is a stepping-stone toward a comprehensive cell atlas of the BM microenvironment.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/116499
url	https://hdl.handle.net/10171/116499
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

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