Impact of Hyperferritinemia on the Outcome of Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation for Lymphoid Malignancies

Hyperferritinemia has been associated with adverse outcomes after allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning. However, its characteristics and impact on the outcome in the reduced-intensity conditioning (RIC) and in the lymphoid malignancy settings are f...

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Detalles Bibliográficos
Autores: Barba, Pere|||0000-0001-7076-7969, Valcárcel, David|||0000-0002-8747-078X, Pérez-Simón, José Antonio|||0000-0003-3616-6101, Fernandez Aviles, Francesc|||0000-0003-3051-3926, Piñana, José Luis|||0000-0001-8533-2562, Martino Bofarull, Rodrigo|||0000-0001-5143-4042, López-Anglada, Lucía|||0000-0003-1727-8546, Rovira Argelagués, Montserrat|||0000-0001-7786-9079, García Cadenas, Irene|||0000-0002-2994-9055, Novelli, Silvana|||0000-0001-8750-0195, Carreras, Enric|||0000-0002-3134-9964, López Corral, Lucia|||0000-0003-1908-5596, Sierra, Jorge|||0000-0002-7966-0356
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:303529
Acceso en línea:https://ddd.uab.cat/record/303529
https://dx.doi.org/urn:doi:10.1016/j.bbmt.2012.12.018
Access Level:acceso abierto
Palabra clave:Ferritin
HCT comorbidity index
Hematopoietic cell transplantation
Lymphoma
Reduced-intensity conditioning
RIC
Descripción
Sumario:Hyperferritinemia has been associated with adverse outcomes after allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning. However, its characteristics and impact on the outcome in the reduced-intensity conditioning (RIC) and in the lymphoid malignancy settings are far from clear. The study includes 201 adult patients undergoing allo-HCT with RIC (allo-RIC) for lymphoid malignancies with a median follow-up for survivors of 52 months (range, 3 to 123). Median serum ferritin level at allo-RIC was 379 ng/mL (range, 4 to 10,790). In the multivariate analysis, patients with hyperferritinemia at transplantation (.

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