Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier
Background The Blood-Brain Barrier (BBB) is a complex and dynamic interface that regulates the exchange of molecules and cells between the blood and the central nervous system. It undergoes structural and functional throughout oxidative stress and inflammation, which may compromise its integrity and...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/728180 |
| Acceso en línea: | https://hdl.handle.net/10486/728180 https://dx.doi.org/10.1186/s12987-024-00599-5 |
| Access Level: | acceso abierto |
| Palabra clave: | NRF2 Blood-Brain Barrier Inflammation Oxidative stress Neurological disorders Tight junction Phytochemicals Medicina Química |
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Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain BarrierCazalla Ibáñez, EduardoCuadrado Pastor, AntonioGarcía Yagüe, Ángel JuanNRF2Blood-Brain BarrierInflammationOxidative stressNeurological disordersTight junctionPhytochemicalsMedicinaQuímicaBackground The Blood-Brain Barrier (BBB) is a complex and dynamic interface that regulates the exchange of molecules and cells between the blood and the central nervous system. It undergoes structural and functional throughout oxidative stress and inflammation, which may compromise its integrity and contribute to the pathogenesis of neurodegenerative diseases. Main body Maintaining BBB integrity is of utmost importance in preventing a wide range of neurological disorders. NRF2 is the main transcription factor that regulates cellular redox balance and inflammation-related gene expression. It has also demonstrated a potential role in regulating tight junction integrity and contributing to the inhibition of ECM remodeling, by reducing the expression of several metalloprotease family members involved in maintaining BBB function. Overall, we review current insights on the role of NRF2 in addressing protection against the effects of BBB dysfunction, discuss its involvement in BBB maintenance in different neuropathological diseases, as well as, some of its potential activators that have been used in vitro and in vivo animal models for preventing barrier dysfunction. Conclusions Thus, emerging evidence suggests that upregulation of NRF2 and its target genes could suppress oxidative stress, and neuroinflammation, restore BBB integrity, and increase its protectionThis research was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) (grands PDC2021-121421-I00, PDC2022-1337665-I00, PID2022-141786OB-I00 and PID2019-110061RB-I00). The Autonomous Community of Madrid (grands S2017BMD-3827 and P2022_BMD-7230). EC is holder of an FPU contract of MIU (Ministry of Universities FPU2021, FPU21/02505)Springer NatureDepartamento de BioquímicaFacultad de MedicinaGobierno de EspañaComunidad de Madrid20242024-11-21review articlehttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/728180https://dx.doi.org/10.1186/s12987-024-00599-539574123reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7281802026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| title |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| spellingShingle |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier Cazalla Ibáñez, Eduardo NRF2 Blood-Brain Barrier Inflammation Oxidative stress Neurological disorders Tight junction Phytochemicals Medicina Química |
| title_short |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| title_full |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| title_fullStr |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| title_full_unstemmed |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| title_sort |
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier |
| dc.creator.none.fl_str_mv |
Cazalla Ibáñez, Eduardo Cuadrado Pastor, Antonio García Yagüe, Ángel Juan |
| author |
Cazalla Ibáñez, Eduardo |
| author_facet |
Cazalla Ibáñez, Eduardo Cuadrado Pastor, Antonio García Yagüe, Ángel Juan |
| author_role |
author |
| author2 |
Cuadrado Pastor, Antonio García Yagüe, Ángel Juan |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
Departamento de Bioquímica Facultad de Medicina Gobierno de España Comunidad de Madrid |
| dc.subject.none.fl_str_mv |
NRF2 Blood-Brain Barrier Inflammation Oxidative stress Neurological disorders Tight junction Phytochemicals Medicina Química |
| topic |
NRF2 Blood-Brain Barrier Inflammation Oxidative stress Neurological disorders Tight junction Phytochemicals Medicina Química |
| description |
Background The Blood-Brain Barrier (BBB) is a complex and dynamic interface that regulates the exchange of molecules and cells between the blood and the central nervous system. It undergoes structural and functional throughout oxidative stress and inflammation, which may compromise its integrity and contribute to the pathogenesis of neurodegenerative diseases. Main body Maintaining BBB integrity is of utmost importance in preventing a wide range of neurological disorders. NRF2 is the main transcription factor that regulates cellular redox balance and inflammation-related gene expression. It has also demonstrated a potential role in regulating tight junction integrity and contributing to the inhibition of ECM remodeling, by reducing the expression of several metalloprotease family members involved in maintaining BBB function. Overall, we review current insights on the role of NRF2 in addressing protection against the effects of BBB dysfunction, discuss its involvement in BBB maintenance in different neuropathological diseases, as well as, some of its potential activators that have been used in vitro and in vivo animal models for preventing barrier dysfunction. Conclusions Thus, emerging evidence suggests that upregulation of NRF2 and its target genes could suppress oxidative stress, and neuroinflammation, restore BBB integrity, and increase its protection |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-11-21 |
| dc.type.none.fl_str_mv |
review article http://purl.org/coar/resource_type/c_dcae04bc AM http://purl.org/coar/version/c_ab4af688f83e57aa |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10486/728180 https://dx.doi.org/10.1186/s12987-024-00599-5 39574123 |
| url |
https://hdl.handle.net/10486/728180 https://dx.doi.org/10.1186/s12987-024-00599-5 |
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39574123 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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