Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls

Background. We conducted a meta-analysis of voxel-based morphometry (VBM) studies in autism spectrum disorder (ASD) to clarify the changes in regional white-matter volume underpinning this condition, and generated an online database to facilitate replication and further analyses by other researchers...

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Autores: Raduà Castaño, Joaquim, Via Virgili, Esther, Catani, Marco, Mataix-Cols, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2011
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/226473
Acceso en línea:https://hdl.handle.net/2445/226473
Access Level:acceso abierto
Palabra clave:Trastorns de l'espectre autista
Comparació (Psicologia)
Marcadors genètics
Autism spectrum disorders
Comparison (Psychology)
Genetic markers
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spelling Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controlsRaduà Castaño, JoaquimVia Virgili, EstherCatani, MarcoMataix-Cols, DavidTrastorns de l'espectre autistaComparació (Psicologia)Marcadors genèticsAutism spectrum disordersComparison (Psychology)Genetic markersBackground. We conducted a meta-analysis of voxel-based morphometry (VBM) studies in autism spectrum disorder (ASD) to clarify the changes in regional white-matter volume underpinning this condition, and generated an online database to facilitate replication and further analyses by other researchers. Method. PubMed, ScienceDirect, Web of Knowledge and Scopus databases were searched between 2002 (the date of the first white-matter VBM study in ASD) and 2010. Manual searches were also conducted. Authors were contacted to obtain additional data. Coordinates were extracted from clusters of significant white-matter difference between patients and controls. A new template for white matter was created for the signed differential mapping (SDM) meta-analytic method. A diffusion tensor imaging (DTI)-derived atlas was used to optimally localize the changes in white-matter volume. Results. Thirteen datasets comprising 246 patients with ASD and 237 healthy controls met inclusion criteria. No between-group differences were found in global white-matter volumes. ASD patients showed increases of white-matter volume in the right arcuate fasciculus and also in the left inferior fronto-occipital and uncinate fasciculi. These findings remained unchanged in quartile and jackknife sensitivity analyses and also in subgroup analyses (pediatric versus adult samples). Conclusions. Patients with ASD display increases of white-matter volume in tracts known to be important for language and social cognition. Whether the results apply to individuals with lower IQ or younger age and whether there are meaningful neurobiological differences between the subtypes of ASD remain to be investigated.Cambridge University Press2026202620112026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion12 p.application/pdfhttps://hdl.handle.net/2445/226473Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1017/S0033291710002187Psychological Medicine, 2011, vol. 41, num. 7, 1539-1550https://doi.org/10.1017/S0033291710002187(c) Cabridge University Press, 2010info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2264732026-05-29T05:05:01Z
dc.title.none.fl_str_mv Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
title Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
spellingShingle Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
Raduà Castaño, Joaquim
Trastorns de l'espectre autista
Comparació (Psicologia)
Marcadors genètics
Autism spectrum disorders
Comparison (Psychology)
Genetic markers
title_short Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
title_full Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
title_fullStr Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
title_full_unstemmed Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
title_sort Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
dc.creator.none.fl_str_mv Raduà Castaño, Joaquim
Via Virgili, Esther
Catani, Marco
Mataix-Cols, David
author Raduà Castaño, Joaquim
author_facet Raduà Castaño, Joaquim
Via Virgili, Esther
Catani, Marco
Mataix-Cols, David
author_role author
author2 Via Virgili, Esther
Catani, Marco
Mataix-Cols, David
author2_role author
author
author
dc.subject.none.fl_str_mv Trastorns de l'espectre autista
Comparació (Psicologia)
Marcadors genètics
Autism spectrum disorders
Comparison (Psychology)
Genetic markers
topic Trastorns de l'espectre autista
Comparació (Psicologia)
Marcadors genètics
Autism spectrum disorders
Comparison (Psychology)
Genetic markers
description Background. We conducted a meta-analysis of voxel-based morphometry (VBM) studies in autism spectrum disorder (ASD) to clarify the changes in regional white-matter volume underpinning this condition, and generated an online database to facilitate replication and further analyses by other researchers. Method. PubMed, ScienceDirect, Web of Knowledge and Scopus databases were searched between 2002 (the date of the first white-matter VBM study in ASD) and 2010. Manual searches were also conducted. Authors were contacted to obtain additional data. Coordinates were extracted from clusters of significant white-matter difference between patients and controls. A new template for white matter was created for the signed differential mapping (SDM) meta-analytic method. A diffusion tensor imaging (DTI)-derived atlas was used to optimally localize the changes in white-matter volume. Results. Thirteen datasets comprising 246 patients with ASD and 237 healthy controls met inclusion criteria. No between-group differences were found in global white-matter volumes. ASD patients showed increases of white-matter volume in the right arcuate fasciculus and also in the left inferior fronto-occipital and uncinate fasciculi. These findings remained unchanged in quartile and jackknife sensitivity analyses and also in subgroup analyses (pediatric versus adult samples). Conclusions. Patients with ASD display increases of white-matter volume in tracts known to be important for language and social cognition. Whether the results apply to individuals with lower IQ or younger age and whether there are meaningful neurobiological differences between the subtypes of ASD remain to be investigated.
publishDate 2011
dc.date.none.fl_str_mv 2011
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226473
url https://hdl.handle.net/2445/226473
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1017/S0033291710002187
Psychological Medicine, 2011, vol. 41, num. 7, 1539-1550
https://doi.org/10.1017/S0033291710002187
dc.rights.none.fl_str_mv (c) Cabridge University Press, 2010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cabridge University Press, 2010
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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