Tratamiento de la enfermedad de Cushing. Cirugía transesfenoidal y radioterapia hipofisaria
Transsphenoidal surgery is currently considered the treatment of choice for Cushing's disease. Initial remission is achieved in approximately 70-85%, but 10-15% of patients with remission will suffer a recurrence months or years later. Pituitary irradiation has been used as a therapeutic tool f...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2009 |
| País: | España |
| Institución: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/33328 |
| Acceso en línea: | https://hdl.handle.net/10578/33328 |
| Access Level: | acceso abierto |
| Palabra clave: | Cirugía transesfenoidal Cushing’s syndrome Hipersecreción hipofisaria de ACTH Pituitary ACTH hypersecretion Pituitary irradiation Radioterapia hipofisaria Síndrome de Cushing Transsphenoidal surgery |
| Sumario: | Transsphenoidal surgery is currently considered the treatment of choice for Cushing's disease. Initial remission is achieved in approximately 70-85%, but 10-15% of patients with remission will suffer a recurrence months or years later. Pituitary irradiation has been used as a therapeutic tool for many years. Nowadays, this option is considered a second-line treatment, to be used when there is postsurgical persistence or recurrence of the disease. The present article reviews the surgical approaches, remission rates reported by different groups, prognostic factors, and the most frequent complications after transsphenoidal surgery. We also review the different techniques that can be used for pituitary irradiation, as well as the efficacy and morbidity reported for each of these techniques in patients with Cushing's disease. |
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