Virus genomes reveal factors that spread and sustained the Ebola epidemic.
The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/46892 |
| Acesso em linha: | https://hdl.handle.net/10578/46892 |
| Access Level: | acceso abierto |
| Palavra-chave: | Ebola virus Epidemiology Genomic sequencing West African Ebola |
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ES_31b7b4bc35518c930225606fdcea2b10 |
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oai:ruidera.uclm.es:10578/46892 |
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ES |
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España |
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|
| dc.title.none.fl_str_mv |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| title |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| spellingShingle |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. Dudas , Gytis Ebola virus Epidemiology Genomic sequencing West African Ebola |
| title_short |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| title_full |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| title_fullStr |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| title_full_unstemmed |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| title_sort |
Virus genomes reveal factors that spread and sustained the Ebola epidemic. |
| dc.creator.none.fl_str_mv |
Dudas , Gytis Carvalho , Luiz Max Bedford , Trevor Tatem , Andrew J Baele , Guy Faria , Nuno R Park , Daniel J Ladner , Jason T Arias Esteban, Armando Asogun Danny Bielejec, Filip Caddy, Sarah L. Cotten, Matthew D’Ambrozio, Jonathan Dellicour, Simon Di Caro,nAntonino Diclaro, Joseph W. Duraffour, Sophie Elmore, Michael J. Fakoli, Lawrence S. Faye, Ousmane Gilbert, Merle L. Gevao, Sahr M. Gire, Stephen Gladden-Young, Adrianne Gnirke, Andreas Goba, Augustine Grant, Donald S. Haagmans, Bart L. Hiscox, Julian A. Jah, Umaru Kugelman, Jeffrey R. Di Liu Jia Lu Malboeuf, Christine M. Mate, Suzanne Matthews, David A. Matranga, Christian B. Meredith, Luke W. Qu, James Quick, Joshua Pas, Suzan D. Phan, My V. T. Pollakis, Georgios Reusken, Chantal B. Sanchez-Lockhart, Mariano Schaffner, Stephen F. Schieffelin, John S. Sealfon, Rachel S. Simon-Loriere, Etienne Smits, Saskia L. Stoecker, Kilian Thorne, Lucy Tobin, Ekaete Alice Vandi, Mohamed A. Watson, Simon J. West, Kendra Whitmer, Shannon Wiley, Michael R. Winnicki, Sarah M. Wohl, Shirlee Wölfel, Roman Yozwiak, Nathan L. Andersen, Kristian G. Blyden, Sylvia O. Bolay, Fatorma Carroll, Miles W. Dahn, Bernice Diallo, Boubacar Formenty, Pierre Fraser, Christophe Gao, George F. Garry, Robert F. Goodfellow, Ian Günther, Stephan Happi, Christian T. Holmes, Edward C. Kargbo, Brima Keïta, Sakoba Kellam, Paul Koopmans, Marion P. G. Kuhn, Jens H. Loman, Nicholas J. Magassouba, N’Faly Naidoo, Dhamari Nichol, Stuart T. Nyenswah, Tolbert Palacios, Gustavo Pybus, Oliver G. Sabeti, Pardis C. Sall, Amadou Ströher, Ute Wurie, Isatta Suchard, Marc A. Lemey, Philippe Rambaut, Andrew R01 AI117011 |
| author |
Dudas , Gytis |
| author_facet |
Dudas , Gytis Carvalho , Luiz Max Bedford , Trevor Tatem , Andrew J Baele , Guy Faria , Nuno R Park , Daniel J Ladner , Jason T Arias Esteban, Armando Asogun Danny Bielejec, Filip Caddy, Sarah L. Cotten, Matthew D’Ambrozio, Jonathan Dellicour, Simon Di Caro,nAntonino Diclaro, Joseph W. Duraffour, Sophie Elmore, Michael J. Fakoli, Lawrence S. Faye, Ousmane Gilbert, Merle L. Gevao, Sahr M. Gire, Stephen Gladden-Young, Adrianne Gnirke, Andreas Goba, Augustine Grant, Donald S. Haagmans, Bart L. Hiscox, Julian A. Jah, Umaru Kugelman, Jeffrey R. Di Liu Jia Lu Malboeuf, Christine M. Mate, Suzanne Matthews, David A. Matranga, Christian B. Meredith, Luke W. Qu, James Quick, Joshua Pas, Suzan D. Phan, My V. T. Pollakis, Georgios Reusken, Chantal B. Sanchez-Lockhart, Mariano Schaffner, Stephen F. Schieffelin, John S. Sealfon, Rachel S. Simon-Loriere, Etienne Smits, Saskia L. Stoecker, Kilian Thorne, Lucy Tobin, Ekaete Alice Vandi, Mohamed A. Watson, Simon J. West, Kendra Whitmer, Shannon Wiley, Michael R. Winnicki, Sarah M. Wohl, Shirlee Wölfel, Roman Yozwiak, Nathan L. Andersen, Kristian G. Blyden, Sylvia O. Bolay, Fatorma Carroll, Miles W. Dahn, Bernice Diallo, Boubacar Formenty, Pierre Fraser, Christophe Gao, George F. Garry, Robert F. Goodfellow, Ian Günther, Stephan Happi, Christian T. Holmes, Edward C. Kargbo, Brima Keïta, Sakoba Kellam, Paul Koopmans, Marion P. G. Kuhn, Jens H. Loman, Nicholas J. Magassouba, N’Faly Naidoo, Dhamari Nichol, Stuart T. Nyenswah, Tolbert Palacios, Gustavo Pybus, Oliver G. Sabeti, Pardis C. Sall, Amadou Ströher, Ute Wurie, Isatta Suchard, Marc A. Lemey, Philippe Rambaut, Andrew R01 AI117011 |
| author_role |
author |
| author2 |
Carvalho , Luiz Max Bedford , Trevor Tatem , Andrew J Baele , Guy Faria , Nuno R Park , Daniel J Ladner , Jason T Arias Esteban, Armando Asogun Danny Bielejec, Filip Caddy, Sarah L. Cotten, Matthew D’Ambrozio, Jonathan Dellicour, Simon Di Caro,nAntonino Diclaro, Joseph W. Duraffour, Sophie Elmore, Michael J. Fakoli, Lawrence S. Faye, Ousmane Gilbert, Merle L. Gevao, Sahr M. Gire, Stephen Gladden-Young, Adrianne Gnirke, Andreas Goba, Augustine Grant, Donald S. Haagmans, Bart L. Hiscox, Julian A. Jah, Umaru Kugelman, Jeffrey R. Di Liu Jia Lu Malboeuf, Christine M. Mate, Suzanne Matthews, David A. Matranga, Christian B. Meredith, Luke W. Qu, James Quick, Joshua Pas, Suzan D. Phan, My V. T. Pollakis, Georgios Reusken, Chantal B. Sanchez-Lockhart, Mariano Schaffner, Stephen F. Schieffelin, John S. Sealfon, Rachel S. Simon-Loriere, Etienne Smits, Saskia L. Stoecker, Kilian Thorne, Lucy Tobin, Ekaete Alice Vandi, Mohamed A. Watson, Simon J. West, Kendra Whitmer, Shannon Wiley, Michael R. Winnicki, Sarah M. Wohl, Shirlee Wölfel, Roman Yozwiak, Nathan L. Andersen, Kristian G. Blyden, Sylvia O. Bolay, Fatorma Carroll, Miles W. Dahn, Bernice Diallo, Boubacar Formenty, Pierre Fraser, Christophe Gao, George F. Garry, Robert F. Goodfellow, Ian Günther, Stephan Happi, Christian T. Holmes, Edward C. Kargbo, Brima Keïta, Sakoba Kellam, Paul Koopmans, Marion P. G. Kuhn, Jens H. Loman, Nicholas J. Magassouba, N’Faly Naidoo, Dhamari Nichol, Stuart T. Nyenswah, Tolbert Palacios, Gustavo Pybus, Oliver G. Sabeti, Pardis C. Sall, Amadou Ströher, Ute Wurie, Isatta Suchard, Marc A. Lemey, Philippe Rambaut, Andrew R01 AI117011 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ebola virus Epidemiology Genomic sequencing West African Ebola |
| topic |
Ebola virus Epidemiology Genomic sequencing West African Ebola |
| description |
The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic ‘gravity’ model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10578/46892 |
| url |
https://hdl.handle.net/10578/46892 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
278433-PREDEMICS (P.L., A.R.) ERC 260864 (P.L., A.R., M.A.S.) 643476-COMPARE (M.P.G.K., A.R.) 634650-VIROGENESIS (P.L., M.P.G.K.) 666100-EVIDENT IFS/2011/272-372, EMLab (S.G.) National Institutes of Health R01 AI107034 R01 HG006139 National Science Foundation IIS 1251151 DMS 1264153 (M.A.S.) NIH AI081982 AI082119 AI082805 AI088843 AI104216 AI104621 AI115754 HSN272200900049C HHSN272201400048C (R.F.G.) NIH R35 GM119774-01 Bill and Melinda Gates Foundation OPP1106427 1032350 OPP1134076 Wellcome Trust 106866/Z/15/Z Key Research and Development Program from the Ministry of Science and Technology of China 2016YFC1200800 (D.L.) National Natural Science Foundation of China 81590760 and 81321063 (G.F.G.) National Institute of Allergy and Infectious Disease U19AI110818 5R01AI114855-03 United States Agency for International Development OAA-G-15-00001 Bill and Melinda Gates Foundation OPP1123407 (P.C.S.) NIH 1U01HG007480-01 World Bank ACE019 (C.T.H.) NIH UL1TR001114 HHSN272201400048C (K.G.A.) HHSN272200700016I |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Macmillan Publishers |
| publisher.none.fl_str_mv |
Macmillan Publishers |
| dc.source.none.fl_str_mv |
reponame:RUIdeRA. Repositorio Institucional de la UCLM instname:Universidad de Castilla-La Mancha |
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Universidad de Castilla-La Mancha |
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RUIdeRA. Repositorio Institucional de la UCLM |
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RUIdeRA. Repositorio Institucional de la UCLM |
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1869405629021421568 |
| spelling |
Virus genomes reveal factors that spread and sustained the Ebola epidemic.Dudas , GytisCarvalho , Luiz MaxBedford , TrevorTatem , Andrew JBaele , GuyFaria , Nuno RPark , Daniel JLadner , Jason TArias Esteban, ArmandoAsogun DannyBielejec, FilipCaddy, Sarah L.Cotten, MatthewD’Ambrozio, JonathanDellicour, SimonDi Caro,nAntoninoDiclaro, Joseph W.Duraffour, SophieElmore, Michael J.Fakoli, Lawrence S.Faye, OusmaneGilbert, Merle L.Gevao, Sahr M.Gire, StephenGladden-Young, AdrianneGnirke, AndreasGoba, AugustineGrant, Donald S.Haagmans, Bart L.Hiscox, Julian A.Jah, UmaruKugelman, Jeffrey R.Di LiuJia LuMalboeuf, Christine M.Mate, SuzanneMatthews, David A.Matranga, Christian B.Meredith, Luke W.Qu, JamesQuick, JoshuaPas, Suzan D.Phan, My V. T.Pollakis, GeorgiosReusken, Chantal B.Sanchez-Lockhart, MarianoSchaffner, Stephen F.Schieffelin, John S.Sealfon, Rachel S.Simon-Loriere, EtienneSmits, Saskia L.Stoecker, KilianThorne, LucyTobin, Ekaete AliceVandi, Mohamed A.Watson, Simon J.West, KendraWhitmer, ShannonWiley, Michael R.Winnicki, Sarah M.Wohl, ShirleeWölfel, RomanYozwiak, Nathan L.Andersen, Kristian G.Blyden, Sylvia O.Bolay, FatormaCarroll, Miles W.Dahn, BerniceDiallo, BoubacarFormenty, PierreFraser, ChristopheGao, George F.Garry, Robert F.Goodfellow, IanGünther, StephanHappi, Christian T.Holmes, Edward C.Kargbo, BrimaKeïta, SakobaKellam, PaulKoopmans, Marion P. G.Kuhn, Jens H.Loman, Nicholas J.Magassouba, N’FalyNaidoo, DhamariNichol, Stuart T.Nyenswah, TolbertPalacios, GustavoPybus, Oliver G.Sabeti, Pardis C.Sall, AmadouStröher, UteWurie, IsattaSuchard, Marc A.Lemey, PhilippeRambaut, AndrewR01 AI117011Ebola virusEpidemiologyGenomic sequencingWest African EbolaThe 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic ‘gravity’ model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.Macmillan Publishers202620262017info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/46892reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglés278433-PREDEMICS (P.L., A.R.)ERC 260864 (P.L., A.R., M.A.S.)643476-COMPARE (M.P.G.K., A.R.)634650-VIROGENESIS (P.L., M.P.G.K.)666100-EVIDENTIFS/2011/272-372, EMLab (S.G.)National Institutes of Health R01 AI107034R01 HG006139National Science Foundation IIS 1251151DMS 1264153 (M.A.S.)NIH AI081982AI082119AI082805AI088843AI104216AI104621AI115754HSN272200900049CHHSN272201400048C (R.F.G.)NIH R35 GM119774-01Bill and Melinda Gates Foundation OPP11064271032350OPP1134076Wellcome Trust 106866/Z/15/ZKey Research and Development Program from the Ministry of Science and Technology of China 2016YFC1200800 (D.L.)National Natural Science Foundation of China 81590760 and 81321063 (G.F.G.)National Institute of Allergy and Infectious Disease U19AI1108185R01AI114855-03United States Agency for International Development OAA-G-15-00001Bill and Melinda Gates Foundation OPP1123407 (P.C.S.)NIH 1U01HG007480-01World Bank ACE019 (C.T.H.)NIH UL1TR001114HHSN272201400048C (K.G.A.)HHSN272200700016Iinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/468922026-05-27T07:36:41Z |
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15.812429 |