Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke

In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an...

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Detalles Bibliográficos
Autores: Delgado-Mederos, Raquel, Gregori Pla, Clara, Zirak, Peyman, Blanco, Igor, Dinia, Lavinia, Marín, Rebeca, Durduran, Turgut, Martí-Fàbregas, Joan
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/114361
Acceso en línea:https://hdl.handle.net/2117/114361
Access Level:acceso abierto
Palabra clave:Cerebrovascular disease
Spectroscopy
Espectroscòpia de làser
Àrees temàtiques de la UPC::Física
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spelling Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic strokeDelgado-Mederos, RaquelGregori Pla, ClaraZirak, PeymanBlanco, IgorDinia, LaviniaMarín, RebecaDurduran, TurgutMartí-Fàbregas, JoanCerebrovascular diseaseSpectroscopyEspectroscòpia de làserÀrees temàtiques de la UPC::FísicaIn this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.Peer ReviewedOSA20182018-02-2120182018-02-22journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/114361reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 DTS16%2F00087 MEDical PHOTonics platform for AGEing (MEDPHOTAGE): Plataforma fotónica, no invasiva, tipo "point-of-care", para la evaluación del riesgo cerebrovascular asociado con el envejecimientoEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructuresopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1143612026-05-27T15:37:01Z
dc.title.none.fl_str_mv Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
title Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
spellingShingle Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
Delgado-Mederos, Raquel
Cerebrovascular disease
Spectroscopy
Espectroscòpia de làser
Àrees temàtiques de la UPC::Física
title_short Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
title_full Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
title_fullStr Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
title_full_unstemmed Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
title_sort Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
dc.creator.none.fl_str_mv Delgado-Mederos, Raquel
Gregori Pla, Clara
Zirak, Peyman
Blanco, Igor
Dinia, Lavinia
Marín, Rebeca
Durduran, Turgut
Martí-Fàbregas, Joan
author Delgado-Mederos, Raquel
author_facet Delgado-Mederos, Raquel
Gregori Pla, Clara
Zirak, Peyman
Blanco, Igor
Dinia, Lavinia
Marín, Rebeca
Durduran, Turgut
Martí-Fàbregas, Joan
author_role author
author2 Gregori Pla, Clara
Zirak, Peyman
Blanco, Igor
Dinia, Lavinia
Marín, Rebeca
Durduran, Turgut
Martí-Fàbregas, Joan
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cerebrovascular disease
Spectroscopy
Espectroscòpia de làser
Àrees temàtiques de la UPC::Física
topic Cerebrovascular disease
Spectroscopy
Espectroscòpia de làser
Àrees temàtiques de la UPC::Física
description In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-02-21
2018
2018-02-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/114361
url https://hdl.handle.net/2117/114361
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 DTS16%2F00087 MEDical PHOTonics platform for AGEing (MEDPHOTAGE): Plataforma fotónica, no invasiva, tipo "point-of-care", para la evaluación del riesgo cerebrovascular asociado con el envejecimiento
European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructures
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv OSA
publisher.none.fl_str_mv OSA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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