XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)

Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevan...

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Autores: Fernández, Óscar, Arés, Adrián, Agüera, Eduardo, Aladro, Yolanda, Alonso, Ana, Arroyo, Rafael, Brieva, Luis, Calles, Carmen, Caminero, Ana Belén, Castillo Triviño, Tamara, Costa Frossard, Lucienne, Eichau, Sara, Hernández, Miguel Ángel, Landete, Lamberto, Llaneza, Miguel, Llufriu, Sara, Meca Lallana, José E., Meca Lallana, Virginia, Moral, Ester, Oreja Guevara, Celia, María Prieto, José, Romero Pinel, Lucía María, Vilaseca, Andreu, Rodríguez Antigüedad, Alfredo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/228188
Acceso en línea:https://hdl.handle.net/2445/228188
Access Level:acceso abierto
Palabra clave:Esclerosi múltiple
Malalties cerebrovasculars
Neuròlegs
Multiple sclerosis
Cerebrovascular disease
Neurologists
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spelling XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)Fernández, ÓscarArés, AdriánAgüera, EduardoAladro, YolandaAlonso, AnaArroyo, RafaelBrieva, LuisCalles, CarmenCaminero, Ana BelénCastillo Triviño, TamaraCosta Frossard, LucienneEichau, SaraHernández, Miguel ÁngelLandete, LambertoLlaneza, MiguelLlufriu, SaraMeca Lallana, José E.Meca Lallana, VirginiaMoral, EsterOreja Guevara, CeliaMaría Prieto, JoséRomero Pinel, Lucía MaríaVilaseca, AndreuRodríguez Antigüedad, AlfredoEsclerosi múltipleMalalties cerebrovascularsNeuròlegsMultiple sclerosisCerebrovascular diseaseNeurologistsIntroduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen. Aim: To present new developments in neurodegeneration and progression, the prodromal phase and diagnosis, the clinical use of biomarkers and neuroimaging, as well as the current role of patient-reported outcomes and digital monitoring. Highlights on the risk of infections and comorbidities in MS are also summarized. Content and Conclusions: In active MS lesions, there is no correlation between the myeloid cell phenotype and remyelination, while memory astrocytes, regulated by the CLEC16A gene, are present in chronic active lesions. Gray matter atrophy is associated with disability and progression independent of relapses, whereas cervical spinal cord atrophy predicts the prognosis of progressive forms and may lead to earlier diagnosis. Healthcare resource utilization increases in the years preceding the first demyelinating event, and although prodromal symptoms are highly variable, they are useful in identifying risk factors for the disease. The new McDonald criteria will facilitate the diagnosis of MS in patients with a radiologically isolated syndrome. Glial fibrillary acidic protein complements neurofilaments, and both biomarkers could soon be standardized for use in clinical practice; paramagnetic rim lesions and slowly expanding lesions are promising imaging markers. In another area, patient-reported health outcomes are valuable, although they are subject to selection bias and the need to define boundaries for their use. Finally, the risk of infections increases before diagnosis and may worsen with certain treatments. Comorbidities in MS should be managed as an integral part of disease management.IMR Press2026202620262026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/228188Comunicacions a congressos (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.31083/RN39227Revista de Neurología, 2026, vol. 81, num. 1, 39227https://doi.org/10.31083/RN39227cc-by (c) Fernández, Óscar et al., 2026https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2281882026-05-29T05:05:01Z
dc.title.none.fl_str_mv XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
title XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
spellingShingle XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
Fernández, Óscar
Esclerosi múltiple
Malalties cerebrovasculars
Neuròlegs
Multiple sclerosis
Cerebrovascular disease
Neurologists
title_short XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
title_full XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
title_fullStr XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
title_full_unstemmed XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
title_sort XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
dc.creator.none.fl_str_mv Fernández, Óscar
Arés, Adrián
Agüera, Eduardo
Aladro, Yolanda
Alonso, Ana
Arroyo, Rafael
Brieva, Luis
Calles, Carmen
Caminero, Ana Belén
Castillo Triviño, Tamara
Costa Frossard, Lucienne
Eichau, Sara
Hernández, Miguel Ángel
Landete, Lamberto
Llaneza, Miguel
Llufriu, Sara
Meca Lallana, José E.
Meca Lallana, Virginia
Moral, Ester
Oreja Guevara, Celia
María Prieto, José
Romero Pinel, Lucía María
Vilaseca, Andreu
Rodríguez Antigüedad, Alfredo
author Fernández, Óscar
author_facet Fernández, Óscar
Arés, Adrián
Agüera, Eduardo
Aladro, Yolanda
Alonso, Ana
Arroyo, Rafael
Brieva, Luis
Calles, Carmen
Caminero, Ana Belén
Castillo Triviño, Tamara
Costa Frossard, Lucienne
Eichau, Sara
Hernández, Miguel Ángel
Landete, Lamberto
Llaneza, Miguel
Llufriu, Sara
Meca Lallana, José E.
Meca Lallana, Virginia
Moral, Ester
Oreja Guevara, Celia
María Prieto, José
Romero Pinel, Lucía María
Vilaseca, Andreu
Rodríguez Antigüedad, Alfredo
author_role author
author2 Arés, Adrián
Agüera, Eduardo
Aladro, Yolanda
Alonso, Ana
Arroyo, Rafael
Brieva, Luis
Calles, Carmen
Caminero, Ana Belén
Castillo Triviño, Tamara
Costa Frossard, Lucienne
Eichau, Sara
Hernández, Miguel Ángel
Landete, Lamberto
Llaneza, Miguel
Llufriu, Sara
Meca Lallana, José E.
Meca Lallana, Virginia
Moral, Ester
Oreja Guevara, Celia
María Prieto, José
Romero Pinel, Lucía María
Vilaseca, Andreu
Rodríguez Antigüedad, Alfredo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi múltiple
Malalties cerebrovasculars
Neuròlegs
Multiple sclerosis
Cerebrovascular disease
Neurologists
topic Esclerosi múltiple
Malalties cerebrovasculars
Neuròlegs
Multiple sclerosis
Cerebrovascular disease
Neurologists
description Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen. Aim: To present new developments in neurodegeneration and progression, the prodromal phase and diagnosis, the clinical use of biomarkers and neuroimaging, as well as the current role of patient-reported outcomes and digital monitoring. Highlights on the risk of infections and comorbidities in MS are also summarized. Content and Conclusions: In active MS lesions, there is no correlation between the myeloid cell phenotype and remyelination, while memory astrocytes, regulated by the CLEC16A gene, are present in chronic active lesions. Gray matter atrophy is associated with disability and progression independent of relapses, whereas cervical spinal cord atrophy predicts the prognosis of progressive forms and may lead to earlier diagnosis. Healthcare resource utilization increases in the years preceding the first demyelinating event, and although prodromal symptoms are highly variable, they are useful in identifying risk factors for the disease. The new McDonald criteria will facilitate the diagnosis of MS in patients with a radiologically isolated syndrome. Glial fibrillary acidic protein complements neurofilaments, and both biomarkers could soon be standardized for use in clinical practice; paramagnetic rim lesions and slowly expanding lesions are promising imaging markers. In another area, patient-reported health outcomes are valuable, although they are subject to selection bias and the need to define boundaries for their use. Finally, the risk of infections increases before diagnosis and may worsen with certain treatments. Comorbidities in MS should be managed as an integral part of disease management.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228188
url https://hdl.handle.net/2445/228188
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.31083/RN39227
Revista de Neurología, 2026, vol. 81, num. 1, 39227
https://doi.org/10.31083/RN39227
dc.rights.none.fl_str_mv cc-by (c) Fernández, Óscar et al., 2026
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fernández, Óscar et al., 2026
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv IMR Press
publisher.none.fl_str_mv IMR Press
dc.source.none.fl_str_mv Comunicacions a congressos (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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