Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.

We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compa...

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Autores: Lee, Seung-Tae, Muench, Marcus O., Fomin, Marina E., Xiao, Jianqiao, Zhou, Mi, Smith, Adam de, Martín-Subero, José Ignacio, Heath, Simon C., Houseman, E.Andres, Roy, Ritu, Wrensch, Margaret, Wiencke, John K., Metayer, Catherine, Wiemels, Joseph L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/119014
Acceso en línea:https://hdl.handle.net/2445/119014
Access Level:acceso abierto
Palabra clave:Leucèmia
Epigenètica
Cèl·lules mare embrionàries
Leukemia
Epigenetics
Embryonic stem cells
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spelling Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.Lee, Seung-TaeMuench, Marcus O.Fomin, Marina E.Xiao, JianqiaoZhou, MiSmith, Adam deMartín-Subero, José IgnacioHeath, Simon C.Houseman, E.AndresRoy, RituWrensch, MargaretWiencke, John K.Metayer, CatherineWiemels, Joseph L.LeucèmiaEpigenèticaCèl·lules mare embrionàriesLeukemiaEpigeneticsEmbryonic stem cellsWe investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators.Oxford University Press2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/119014Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/nar/gkv103Nucleic Acids Research, 2015, vol. 43, num. 5, p. 2590-2602https://doi.org/10.1093/nar/gkv103cc-by-nc (c) Lee, Seung-Tae et al., 2015http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1190142026-05-29T05:05:01Z
dc.title.none.fl_str_mv Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
title Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
spellingShingle Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
Lee, Seung-Tae
Leucèmia
Epigenètica
Cèl·lules mare embrionàries
Leukemia
Epigenetics
Embryonic stem cells
title_short Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
title_full Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
title_fullStr Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
title_full_unstemmed Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
title_sort Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
dc.creator.none.fl_str_mv Lee, Seung-Tae
Muench, Marcus O.
Fomin, Marina E.
Xiao, Jianqiao
Zhou, Mi
Smith, Adam de
Martín-Subero, José Ignacio
Heath, Simon C.
Houseman, E.Andres
Roy, Ritu
Wrensch, Margaret
Wiencke, John K.
Metayer, Catherine
Wiemels, Joseph L.
author Lee, Seung-Tae
author_facet Lee, Seung-Tae
Muench, Marcus O.
Fomin, Marina E.
Xiao, Jianqiao
Zhou, Mi
Smith, Adam de
Martín-Subero, José Ignacio
Heath, Simon C.
Houseman, E.Andres
Roy, Ritu
Wrensch, Margaret
Wiencke, John K.
Metayer, Catherine
Wiemels, Joseph L.
author_role author
author2 Muench, Marcus O.
Fomin, Marina E.
Xiao, Jianqiao
Zhou, Mi
Smith, Adam de
Martín-Subero, José Ignacio
Heath, Simon C.
Houseman, E.Andres
Roy, Ritu
Wrensch, Margaret
Wiencke, John K.
Metayer, Catherine
Wiemels, Joseph L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leucèmia
Epigenètica
Cèl·lules mare embrionàries
Leukemia
Epigenetics
Embryonic stem cells
topic Leucèmia
Epigenètica
Cèl·lules mare embrionàries
Leukemia
Epigenetics
Embryonic stem cells
description We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119014
url https://hdl.handle.net/2445/119014
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/nar/gkv103
Nucleic Acids Research, 2015, vol. 43, num. 5, p. 2590-2602
https://doi.org/10.1093/nar/gkv103
dc.rights.none.fl_str_mv cc-by-nc (c) Lee, Seung-Tae et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Lee, Seung-Tae et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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