Effect of finerenone on ambulatory blood pressure in chronic kidney disease in type 2 diabetes
Objective: Finerenone is a selective nonsteroidal mineralocorticoid receptor antagonist with a short half-life. Its effects on cardiorenal outcomes were thought to be mediated primarily via nonhemodynamic pathways, but office blood pressure (BP) measurements were insufficient to fully assess hemodyn...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/718807 |
| Acceso en línea: | http://hdl.handle.net/10486/718807 https://dx.doi.org/10.1097/HJH.0000000000003330 |
| Access Level: | acceso abierto |
| Palabra clave: | albuminuria ambulatory blood pressure monitoring chronic kidney disease finerenone type 2 diabetes Medicina |
| Sumario: | Objective: Finerenone is a selective nonsteroidal mineralocorticoid receptor antagonist with a short half-life. Its effects on cardiorenal outcomes were thought to be mediated primarily via nonhemodynamic pathways, but office blood pressure (BP) measurements were insufficient to fully assess hemodynamic effects. This analysis assessed the effects of finerenone on 24-h ambulatory BP in patients with chronic kidney disease and type 2 diabetes. Methods: ARTS-DN (NCT01874431) was a phase 2b trial that randomized 823 patients with type 2 diabetes and chronic kidney disease, with urine albumin-to-creatinine ratio ≥30 mg/g and estimated glomerular filtration rate of 30–90ml/min per 1.73m2 to placebo or finerenone (1.25–20mg once daily in the morning) administered over 90days. Ambulatory BP monitoring (ABPM) over 24h was performed in a subset of 240 patients at screening, Day 60, and Day 90. Results: Placebo-adjusted change in 24-h ABPM systolic BP (SBP) at Day 90 was –8.3 mmHg (95% confidence interval [CI], –16.6 to 0.1) for finerenone 10mg (n=27), –11.2 mmHg (95% CI, –18.8 to –3.6) for finerenone 15mg (n=34), and –9.9mmHg (95% CI, –17.7 to –2.0) for finerenone 20mg (n=31). Mean daytime and nighttime SBP recordings were similarly reduced and finerenone did not increase the incidence of SBP dipping. Finerenone produced a persistent reduction in SBP over the entire 24-h interval. Conclusions: Finerenone reduced 24-h, daytime, and night-time SBP. Despite a short half-life, changes in BP were persistent over 24h with once-daily dosing in the morning |
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