Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma

Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with g...

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Autores: Puig Alcántara, Josep, Sánchez González, Javier, Blasco Solà, Gerard, Daunis-i-Estadella, Pepus, Federau, Christian, Alberich Bayarri, Ángel, Biarnés, Carles, Nael, Kambiz, Essig, Marco, Jain, Rajan, Wintermark, Max, Pedraza, S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/14046
Acceso en línea:http://hdl.handle.net/10256/14046
Access Level:acceso abierto
Palabra clave:Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
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spelling Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in GlioblastomaPuig Alcántara, JosepSánchez González, JavierBlasco Solà, GerardDaunis-i-Estadella, PepusFederau, ChristianAlberich Bayarri, ÁngelBiarnés, CarlesNael, KambizEssig, MarcoJain, RajanWintermark, MaxPedraza, S.Ressonància magnèticaMagnetic resonanceCervell -- TumorsBrain -- TumorsGliomesGliomasIntravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses. Results We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy. Conclusions The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastomaPublic Library of Science (PLoS)2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/14046http://hdl.handle.net/10256/14046PLoS One, 2016, vol. 11, núm. 7, p. e0158887Articles publicats (D-IMA)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158887info:eu-repo/semantics/altIdentifier/eissn/1932-6203Attribution 4.0 Spainhttp://creativecommons.org/licenses/by4.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/140462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
title Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
spellingShingle Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
Puig Alcántara, Josep
Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
title_short Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
title_full Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
title_fullStr Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
title_full_unstemmed Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
title_sort Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
dc.creator.none.fl_str_mv Puig Alcántara, Josep
Sánchez González, Javier
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Federau, Christian
Alberich Bayarri, Ángel
Biarnés, Carles
Nael, Kambiz
Essig, Marco
Jain, Rajan
Wintermark, Max
Pedraza, S.
author Puig Alcántara, Josep
author_facet Puig Alcántara, Josep
Sánchez González, Javier
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Federau, Christian
Alberich Bayarri, Ángel
Biarnés, Carles
Nael, Kambiz
Essig, Marco
Jain, Rajan
Wintermark, Max
Pedraza, S.
author_role author
author2 Sánchez González, Javier
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Federau, Christian
Alberich Bayarri, Ángel
Biarnés, Carles
Nael, Kambiz
Essig, Marco
Jain, Rajan
Wintermark, Max
Pedraza, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
topic Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
description Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses. Results We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy. Conclusions The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastoma
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/14046
http://hdl.handle.net/10256/14046
url http://hdl.handle.net/10256/14046
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158887
info:eu-repo/semantics/altIdentifier/eissn/1932-6203
dc.rights.none.fl_str_mv Attribution 4.0 Spain
http://creativecommons.org/licenses/by4.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 Spain
http://creativecommons.org/licenses/by4.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv PLoS One, 2016, vol. 11, núm. 7, p. e0158887
Articles publicats (D-IMA)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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