Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population

Determine short-term changes in tear film volume and stability after various treat-ments for dry eye disease in healthy participants. Methods: 36 healthy participants aged from 18-35 years were recruited for a single-session examination and randomly assigned to one of three treatment groups (1:1:1 t...

Descripción completa

Detalles Bibliográficos
Autores: Sabucedo Villamarín, Belén, García Queiruga, Jacobo, Cacabelos Torres, Laura, Giráldez Fernández, María Jesús, Yebra-Pimentel Vilar, Eva, Pena Verdeal, Hugo
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/42234
Acceso en línea:https://hdl.handle.net/10347/42234
Access Level:acceso abierto
Palabra clave:Dry Eye Disease
Dry Eye ManagemenT
Artificial Tears
Eyelid Cleansing Wipes
Ocular Bath
220915 Optometría
id ES_31061ba6e1b2daf98cd3090a47c04829
oai_identifier_str oai:minerva.usc.gal:10347/42234
network_acronym_str ES
network_name_str España
repository_id_str
spelling Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young populationSabucedo Villamarín, BelénGarcía Queiruga, JacoboCacabelos Torres, LauraGiráldez Fernández, María JesúsYebra-Pimentel Vilar, EvaPena Verdeal, HugoDry Eye DiseaseDry Eye ManagemenTArtificial TearsEyelid Cleansing WipesOcular Bath220915 OptometríaDetermine short-term changes in tear film volume and stability after various treat-ments for dry eye disease in healthy participants. Methods: 36 healthy participants aged from 18-35 years were recruited for a single-session examination and randomly assigned to one of three treatment groups (1:1:1 treatment, 1:1 eye): Group 1 (artificial tears ‘Comfort Drops’), Group 2 (eyelid wipes ‘Systane Lid Wipes’), and Group 3 (ocu-lar bath ‘Acuaiss’). Tear Meniscus Height (TMH) was assessed at baseline, 2, 5, 10, 15, and 20 minutes, and Non-Invasive Break-Up Time (NIBUT) at baseline, 2, 10, and 20 minutes, all using the OCULUS Keratograph 5M by one examiner. Results: Of the ini-tially recruited participants, 35 were analyzed; one was excluded for reflex tearing. Group 1 (n=12) showed a significant TMH increase at 2 minutes compared to 10 and 20 minutes (Friedman, p=0.004; Bonferroni, p≤0.028). Group 3 (n=12) showed a signif-icant increase at 2 and 5 minutes compared to baseline and decrease at 10 minutes against 2 and 5 minutes (Friedman, p<0.001; Bonferroni, p≤0.034). Group 2 (n=11) showed no significant changes over time (Friedman, p=0.108). NIBUT showed no sig-nificant differences at any time point in any group (Friedman, p≥0.231). Basal TMH differed between groups (ANOVA, p=0.048), but post-hoc analysis found no signifi-cance (Bonferroni, all p≥0.088). No significant differences in TMH at other time points (Kruskal-Wallis/ANOVA, p≥0.265) or in NIBUT between groups (Krus-kal-Wallis/ANOVA, p=0.108) were found. Conclusion: In healthy participants, artifi-cial tears and ocular baths temporarily increase TMH, while eyelid wipes don´t. Nei-ther has an immediate impact on NIBUTMDPIUniversidade de Santiago de Compostela. Departamento de Física Aplicada20252025-04-2720252025-04-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/42234reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/422342026-06-15T12:47:27Z
dc.title.none.fl_str_mv Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
title Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
spellingShingle Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
Sabucedo Villamarín, Belén
Dry Eye Disease
Dry Eye ManagemenT
Artificial Tears
Eyelid Cleansing Wipes
Ocular Bath
220915 Optometría
title_short Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
title_full Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
title_fullStr Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
title_full_unstemmed Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
title_sort Short-term changes in tear film stability and tear volume fol-lowing the application of various DED management options in a healthy young population
dc.creator.none.fl_str_mv Sabucedo Villamarín, Belén
García Queiruga, Jacobo
Cacabelos Torres, Laura
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
Pena Verdeal, Hugo
author Sabucedo Villamarín, Belén
author_facet Sabucedo Villamarín, Belén
García Queiruga, Jacobo
Cacabelos Torres, Laura
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
Pena Verdeal, Hugo
author_role author
author2 García Queiruga, Jacobo
Cacabelos Torres, Laura
Giráldez Fernández, María Jesús
Yebra-Pimentel Vilar, Eva
Pena Verdeal, Hugo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Física Aplicada
dc.subject.none.fl_str_mv Dry Eye Disease
Dry Eye ManagemenT
Artificial Tears
Eyelid Cleansing Wipes
Ocular Bath
220915 Optometría
topic Dry Eye Disease
Dry Eye ManagemenT
Artificial Tears
Eyelid Cleansing Wipes
Ocular Bath
220915 Optometría
description Determine short-term changes in tear film volume and stability after various treat-ments for dry eye disease in healthy participants. Methods: 36 healthy participants aged from 18-35 years were recruited for a single-session examination and randomly assigned to one of three treatment groups (1:1:1 treatment, 1:1 eye): Group 1 (artificial tears ‘Comfort Drops’), Group 2 (eyelid wipes ‘Systane Lid Wipes’), and Group 3 (ocu-lar bath ‘Acuaiss’). Tear Meniscus Height (TMH) was assessed at baseline, 2, 5, 10, 15, and 20 minutes, and Non-Invasive Break-Up Time (NIBUT) at baseline, 2, 10, and 20 minutes, all using the OCULUS Keratograph 5M by one examiner. Results: Of the ini-tially recruited participants, 35 were analyzed; one was excluded for reflex tearing. Group 1 (n=12) showed a significant TMH increase at 2 minutes compared to 10 and 20 minutes (Friedman, p=0.004; Bonferroni, p≤0.028). Group 3 (n=12) showed a signif-icant increase at 2 and 5 minutes compared to baseline and decrease at 10 minutes against 2 and 5 minutes (Friedman, p<0.001; Bonferroni, p≤0.034). Group 2 (n=11) showed no significant changes over time (Friedman, p=0.108). NIBUT showed no sig-nificant differences at any time point in any group (Friedman, p≥0.231). Basal TMH differed between groups (ANOVA, p=0.048), but post-hoc analysis found no signifi-cance (Bonferroni, all p≥0.088). No significant differences in TMH at other time points (Kruskal-Wallis/ANOVA, p≥0.265) or in NIBUT between groups (Krus-kal-Wallis/ANOVA, p=0.108) were found. Conclusion: In healthy participants, artifi-cial tears and ocular baths temporarily increase TMH, while eyelid wipes don´t. Nei-ther has an immediate impact on NIBUT
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-27
2025
2025-04-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/42234
url https://hdl.handle.net/10347/42234
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405584311189504
score 15,811543

Similares en LA Referencia