Association Between Body Size Phenotypes and Subclinical Atherosclerosis

Context: The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood. Objective: To evaluate the association between body size phenotypes and subclinical atherosclerosis. Design: Cross-sectional. Setting: Cardiovascular d...

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Detalhes bibliográficos
Autores: Rossello, Xavier, Fuster, Valentin, Oliva, Belen, Sanz, Javier, Fernandez-Friera, Leticia, Lopez-Melgar, Beatriz, Mendiguren, Jose M, Lara-Pezzi, Enrique, Bueno, Hector, Fernandez-Ortiz, Antonio, Ibáñez, Borja, Ordovas, Jose M
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11189
Acesso em linha:http://hdl.handle.net/20.500.12105/11189
Access Level:acceso abierto
Palavra-chave:Body size phenotypes
Obesity
Subclinical atherosclerosis
Estudios de Cohortes
Enfermedades Asintomáticas
Prevalencia
Tamaño Corporal
Femenino
Masculino
Aterosclerosis
Estudios Transversales
Factores de Riesgo
Humanos
Persona de Mediana Edad
Fenotipo
Adulto
España
Spain
Adult
Humans
Body Size
Middle Aged
Cross-Sectional Studies
Asymptomatic Diseases
Phenotype
Male
Female
Risk Factors
Atherosclerosis
Cohort Studies
Prevalence
Cardiovascular risk
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spelling Association Between Body Size Phenotypes and Subclinical AtherosclerosisRossello, XavierFuster, ValentinOliva, BelenSanz, JavierFernandez-Friera, LeticiaLopez-Melgar, BeatrizMendiguren, Jose MLara-Pezzi, EnriqueBueno, HectorFernandez-Ortiz, AntonioIbáñez, BorjaOrdovas, Jose MBody size phenotypesObesitySubclinical atherosclerosisEstudios de CohortesEnfermedades AsintomáticasPrevalenciaTamaño CorporalFemeninoMasculinoAterosclerosisEstudios TransversalesFactores de RiesgoHumanosPersona de Mediana EdadFenotipoAdultoEspañaSpainAdultHumansBody SizeMiddle AgedCross-Sectional StudiesAsymptomatic DiseasesPhenotypeMaleFemaleRisk FactorsAtherosclerosisCohort StudiesPrevalenceCardiovascular riskContext: The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood. Objective: To evaluate the association between body size phenotypes and subclinical atherosclerosis. Design: Cross-sectional. Setting: Cardiovascular disease-free cohort. Participants: Middle-aged asymptomatic subjects (n = 3909). A total of 6 cardiometabolic body size phenotypes were defined based on the presence of at least 1 cardiometabolic abnormality (blood pressure, fasting blood glucose, triglycerides, low high-density lipoprotein cholesterol, homeostasis model assessment-insulin resistance index, high-sensitivity C-reactive protein) and based on BMI: normal-weight (NW; BMI <25), overweight (OW; BMI = 25.0-29.9) or obese (08; BMI >30.0). Main Outcome Measures: Subclinical atherosclerosis was evaluated by 2D vascular ultrasonography and noncontrast cardiac computed tomography. Results: For metabolically healthy subjects, the presence of subclinical atherosclerosis increased across BMI categories (49.6%, 58.0%, and 67.7% for NW, OW, and OB, respectively), whereas fewer differences were observed for metabolically unhealthy subjects (61.1%, 69.7%, and 70.5%, respectively). When BMI and cardiometabolic abnormalities were assessed separately, the association of body size phenotypes with the extent of subclinical atherosclerosis was mostly driven by the coexistence of cardiometabolic risk factors: adjusted OR = 1.04 (95% confidence interval [CI), 0.90-1.19) for OW and OR = 1.07 (95% CI, 0.88-1.30) for OB in comparison with NW, whereas there was an increasing association between the extent of subclinical atherosclerosis and the number of cardiometabolic abnormalities: adjusted OR = 1.21 (95% CI, 1.05-1.40),1.60 (95% Cl, 1.33-1.93), 1.92 (95% CI, 1.48-2.50), and 2.27 (95% Cl, 1.67-3.09) for 1, 2, 3, and >3, respectively, in comparison with noncardiometabolic abnormalities. Conclusions: The prevalence of subclinical atherosclerosis varies across body size phenotypes. Pharmacologic and lifestyle interventions might modify their cardiovascular risk by facilitating the transition from one phenotype to another.Oxford University PressCentro Nacional de Investigaciones Cardiovasculares Carlos III (España)Banco SantanderInstituto de Salud Carlos IIIEuropean Regional Development FundFundación ProCNIC20202020-10-2120202020-12-0120202020-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/11189reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES SEV-2015-0505 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/111892026-06-12T12:43:37Z
dc.title.none.fl_str_mv Association Between Body Size Phenotypes and Subclinical Atherosclerosis
title Association Between Body Size Phenotypes and Subclinical Atherosclerosis
spellingShingle Association Between Body Size Phenotypes and Subclinical Atherosclerosis
Rossello, Xavier
Body size phenotypes
Obesity
Subclinical atherosclerosis
Estudios de Cohortes
Enfermedades Asintomáticas
Prevalencia
Tamaño Corporal
Femenino
Masculino
Aterosclerosis
Estudios Transversales
Factores de Riesgo
Humanos
Persona de Mediana Edad
Fenotipo
Adulto
España
Spain
Adult
Humans
Body Size
Middle Aged
Cross-Sectional Studies
Asymptomatic Diseases
Phenotype
Male
Female
Risk Factors
Atherosclerosis
Cohort Studies
Prevalence
Cardiovascular risk
title_short Association Between Body Size Phenotypes and Subclinical Atherosclerosis
title_full Association Between Body Size Phenotypes and Subclinical Atherosclerosis
title_fullStr Association Between Body Size Phenotypes and Subclinical Atherosclerosis
title_full_unstemmed Association Between Body Size Phenotypes and Subclinical Atherosclerosis
title_sort Association Between Body Size Phenotypes and Subclinical Atherosclerosis
dc.creator.none.fl_str_mv Rossello, Xavier
Fuster, Valentin
Oliva, Belen
Sanz, Javier
Fernandez-Friera, Leticia
Lopez-Melgar, Beatriz
Mendiguren, Jose M
Lara-Pezzi, Enrique
Bueno, Hector
Fernandez-Ortiz, Antonio
Ibáñez, Borja
Ordovas, Jose M
author Rossello, Xavier
author_facet Rossello, Xavier
Fuster, Valentin
Oliva, Belen
Sanz, Javier
Fernandez-Friera, Leticia
Lopez-Melgar, Beatriz
Mendiguren, Jose M
Lara-Pezzi, Enrique
Bueno, Hector
Fernandez-Ortiz, Antonio
Ibáñez, Borja
Ordovas, Jose M
author_role author
author2 Fuster, Valentin
Oliva, Belen
Sanz, Javier
Fernandez-Friera, Leticia
Lopez-Melgar, Beatriz
Mendiguren, Jose M
Lara-Pezzi, Enrique
Bueno, Hector
Fernandez-Ortiz, Antonio
Ibáñez, Borja
Ordovas, Jose M
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
Banco Santander
Instituto de Salud Carlos III
European Regional Development Fund
Fundación ProCNIC
dc.subject.none.fl_str_mv Body size phenotypes
Obesity
Subclinical atherosclerosis
Estudios de Cohortes
Enfermedades Asintomáticas
Prevalencia
Tamaño Corporal
Femenino
Masculino
Aterosclerosis
Estudios Transversales
Factores de Riesgo
Humanos
Persona de Mediana Edad
Fenotipo
Adulto
España
Spain
Adult
Humans
Body Size
Middle Aged
Cross-Sectional Studies
Asymptomatic Diseases
Phenotype
Male
Female
Risk Factors
Atherosclerosis
Cohort Studies
Prevalence
Cardiovascular risk
topic Body size phenotypes
Obesity
Subclinical atherosclerosis
Estudios de Cohortes
Enfermedades Asintomáticas
Prevalencia
Tamaño Corporal
Femenino
Masculino
Aterosclerosis
Estudios Transversales
Factores de Riesgo
Humanos
Persona de Mediana Edad
Fenotipo
Adulto
España
Spain
Adult
Humans
Body Size
Middle Aged
Cross-Sectional Studies
Asymptomatic Diseases
Phenotype
Male
Female
Risk Factors
Atherosclerosis
Cohort Studies
Prevalence
Cardiovascular risk
description Context: The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood. Objective: To evaluate the association between body size phenotypes and subclinical atherosclerosis. Design: Cross-sectional. Setting: Cardiovascular disease-free cohort. Participants: Middle-aged asymptomatic subjects (n = 3909). A total of 6 cardiometabolic body size phenotypes were defined based on the presence of at least 1 cardiometabolic abnormality (blood pressure, fasting blood glucose, triglycerides, low high-density lipoprotein cholesterol, homeostasis model assessment-insulin resistance index, high-sensitivity C-reactive protein) and based on BMI: normal-weight (NW; BMI <25), overweight (OW; BMI = 25.0-29.9) or obese (08; BMI >30.0). Main Outcome Measures: Subclinical atherosclerosis was evaluated by 2D vascular ultrasonography and noncontrast cardiac computed tomography. Results: For metabolically healthy subjects, the presence of subclinical atherosclerosis increased across BMI categories (49.6%, 58.0%, and 67.7% for NW, OW, and OB, respectively), whereas fewer differences were observed for metabolically unhealthy subjects (61.1%, 69.7%, and 70.5%, respectively). When BMI and cardiometabolic abnormalities were assessed separately, the association of body size phenotypes with the extent of subclinical atherosclerosis was mostly driven by the coexistence of cardiometabolic risk factors: adjusted OR = 1.04 (95% confidence interval [CI), 0.90-1.19) for OW and OR = 1.07 (95% CI, 0.88-1.30) for OB in comparison with NW, whereas there was an increasing association between the extent of subclinical atherosclerosis and the number of cardiometabolic abnormalities: adjusted OR = 1.21 (95% CI, 1.05-1.40),1.60 (95% Cl, 1.33-1.93), 1.92 (95% CI, 1.48-2.50), and 2.27 (95% Cl, 1.67-3.09) for 1, 2, 3, and >3, respectively, in comparison with noncardiometabolic abnormalities. Conclusions: The prevalence of subclinical atherosclerosis varies across body size phenotypes. Pharmacologic and lifestyle interventions might modify their cardiovascular risk by facilitating the transition from one phenotype to another.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-10-21
2020
2020-12-01
2020
2020-12-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/11189
url http://hdl.handle.net/20.500.12105/11189
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES SEV-2015-0505 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405581416071168
score 15,811543

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