Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)

The introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)-mediated allergies. However, it can be chall...

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Authors: Pascal, Mariona|||0000-0003-0549-9720, Moreno Aguilar, Carmen|||0000-0003-1338-7753, Dávila, Ignacio|||0000-0001-8485-5513, Tabar, Ana isabel, Bartra, Joan|||0000-0001-7767-4730, Labrador Horrillo, Moises|||0000-0003-3222-2380, Luengo Sánchez, Olga|||0000-0002-8905-2776
Format: article
Publication Date:2021
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:292276
Online Access:https://ddd.uab.cat/record/292276
https://dx.doi.org/urn:doi:10.1002/clt2.12052
Access Level:Open access
Keyword:Allergy
IgE
IgE ratio
Molecular diagnosis
Recommendations
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spelling Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)Pascal, Mariona|||0000-0003-0549-9720Moreno Aguilar, Carmen|||0000-0003-1338-7753Dávila, Ignacio|||0000-0001-8485-5513Tabar, Ana isabelBartra, Joan|||0000-0001-7767-4730Labrador Horrillo, Moises|||0000-0003-3222-2380Luengo Sánchez, Olga|||0000-0002-8905-2776AllergyIgEIgE ratioMolecular diagnosisRecommendationsThe introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)-mediated allergies. However, it can be challenging to accurately interpret the results of molecular assays, partly due to the limited evidence base. In this context, a panel of experts with extensive experience in interpreting in vitro measures of total and serum specific IgE reviewed the available scientific evidence. After this review, the panel selected a series of representative case studies to demonstrate how determination of specific and total IgE values and the relationship between them (ratio analysis) can add value to the diagnostic process by more precisely defining the patient's sensitization profile. Finally, the experts developed a series of recommendations on the clinical application of ratio analysis to optimize and complement the classical approach to allergy diagnosis.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292276https://dx.doi.org/urn:doi:10.1002/clt2.12052reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2922762026-06-06T12:50:31Z
dc.title.none.fl_str_mv Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
title Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
spellingShingle Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
Pascal, Mariona|||0000-0003-0549-9720
Allergy
IgE
IgE ratio
Molecular diagnosis
Recommendations
title_short Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
title_full Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
title_fullStr Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
title_full_unstemmed Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
title_sort Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA)
dc.creator.none.fl_str_mv Pascal, Mariona|||0000-0003-0549-9720
Moreno Aguilar, Carmen|||0000-0003-1338-7753
Dávila, Ignacio|||0000-0001-8485-5513
Tabar, Ana isabel
Bartra, Joan|||0000-0001-7767-4730
Labrador Horrillo, Moises|||0000-0003-3222-2380
Luengo Sánchez, Olga|||0000-0002-8905-2776
author Pascal, Mariona|||0000-0003-0549-9720
author_facet Pascal, Mariona|||0000-0003-0549-9720
Moreno Aguilar, Carmen|||0000-0003-1338-7753
Dávila, Ignacio|||0000-0001-8485-5513
Tabar, Ana isabel
Bartra, Joan|||0000-0001-7767-4730
Labrador Horrillo, Moises|||0000-0003-3222-2380
Luengo Sánchez, Olga|||0000-0002-8905-2776
author_role author
author2 Moreno Aguilar, Carmen|||0000-0003-1338-7753
Dávila, Ignacio|||0000-0001-8485-5513
Tabar, Ana isabel
Bartra, Joan|||0000-0001-7767-4730
Labrador Horrillo, Moises|||0000-0003-3222-2380
Luengo Sánchez, Olga|||0000-0002-8905-2776
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Allergy
IgE
IgE ratio
Molecular diagnosis
Recommendations
topic Allergy
IgE
IgE ratio
Molecular diagnosis
Recommendations
description The introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)-mediated allergies. However, it can be challenging to accurately interpret the results of molecular assays, partly due to the limited evidence base. In this context, a panel of experts with extensive experience in interpreting in vitro measures of total and serum specific IgE reviewed the available scientific evidence. After this review, the panel selected a series of representative case studies to demonstrate how determination of specific and total IgE values and the relationship between them (ratio analysis) can add value to the diagnostic process by more precisely defining the patient's sensitization profile. Finally, the experts developed a series of recommendations on the clinical application of ratio analysis to optimize and complement the classical approach to allergy diagnosis.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/292276
https://dx.doi.org/urn:doi:10.1002/clt2.12052
url https://ddd.uab.cat/record/292276
https://dx.doi.org/urn:doi:10.1002/clt2.12052
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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