Chromosomal bands affected by acute oil exposure and DNA repair errors

BACKGROUND: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA...

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Autores: Monyarch, Gemma, Castro Reis, Fernanda de, Zock, Jan-Paul, Pozo-Rodríguez, Francisco, Espinosa Cardiel, Ana, Giraldo, Jesús, Rodríguez-Trigo, Gema, Castaño-Vinyals, Gemma, Gómez, Federico Pablo, Verea, Héctor, Antó i Boqué, Josep Maria, Coll, Maria Dolors, Barberà i Mir, Joan Albert, Fuster, Carme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/97221
Acceso en línea:https://hdl.handle.net/2445/97221
Access Level:acceso abierto
Palabra clave:Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Hidrocarburs
ADN
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Hydrocarbons
DNA
Cancer
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spelling Chromosomal bands affected by acute oil exposure and DNA repair errorsMonyarch, GemmaCastro Reis, Fernanda deZock, Jan-PaulPozo-Rodríguez, FranciscoEspinosa Cardiel, AnaGiraldo, JesúsRodríguez-Trigo, GemaCastaño-Vinyals, GemmaGómez, Federico PabloVerea, HéctorAntó i Boqué, Josep MariaColl, Maria DolorsBarberà i Mir, Joan AlbertFuster, CarmeCatàstrofe del Prestige, Espanya, 2002Mutació (Biologia)HidrocarbursADNCàncerPrestige oil spill, Spain, 2002Mutation (Biology)HydrocarbonsDNACancerBACKGROUND: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. OBJECTIVES: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. METHODS: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. RESULTS: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016). CONCLUSION: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.Public Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/97221Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0081276PLoS One, 2013, vol. 8, num. 11, p. e81276http://dx.doi.org/10.1371/journal.pone.0081276cc-by (c) Monyarch, G. et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/972212026-05-27T06:46:51Z
dc.title.none.fl_str_mv Chromosomal bands affected by acute oil exposure and DNA repair errors
title Chromosomal bands affected by acute oil exposure and DNA repair errors
spellingShingle Chromosomal bands affected by acute oil exposure and DNA repair errors
Monyarch, Gemma
Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Hidrocarburs
ADN
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Hydrocarbons
DNA
Cancer
title_short Chromosomal bands affected by acute oil exposure and DNA repair errors
title_full Chromosomal bands affected by acute oil exposure and DNA repair errors
title_fullStr Chromosomal bands affected by acute oil exposure and DNA repair errors
title_full_unstemmed Chromosomal bands affected by acute oil exposure and DNA repair errors
title_sort Chromosomal bands affected by acute oil exposure and DNA repair errors
dc.creator.none.fl_str_mv Monyarch, Gemma
Castro Reis, Fernanda de
Zock, Jan-Paul
Pozo-Rodríguez, Francisco
Espinosa Cardiel, Ana
Giraldo, Jesús
Rodríguez-Trigo, Gema
Castaño-Vinyals, Gemma
Gómez, Federico Pablo
Verea, Héctor
Antó i Boqué, Josep Maria
Coll, Maria Dolors
Barberà i Mir, Joan Albert
Fuster, Carme
author Monyarch, Gemma
author_facet Monyarch, Gemma
Castro Reis, Fernanda de
Zock, Jan-Paul
Pozo-Rodríguez, Francisco
Espinosa Cardiel, Ana
Giraldo, Jesús
Rodríguez-Trigo, Gema
Castaño-Vinyals, Gemma
Gómez, Federico Pablo
Verea, Héctor
Antó i Boqué, Josep Maria
Coll, Maria Dolors
Barberà i Mir, Joan Albert
Fuster, Carme
author_role author
author2 Castro Reis, Fernanda de
Zock, Jan-Paul
Pozo-Rodríguez, Francisco
Espinosa Cardiel, Ana
Giraldo, Jesús
Rodríguez-Trigo, Gema
Castaño-Vinyals, Gemma
Gómez, Federico Pablo
Verea, Héctor
Antó i Boqué, Josep Maria
Coll, Maria Dolors
Barberà i Mir, Joan Albert
Fuster, Carme
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Hidrocarburs
ADN
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Hydrocarbons
DNA
Cancer
topic Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Hidrocarburs
ADN
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Hydrocarbons
DNA
Cancer
description BACKGROUND: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. OBJECTIVES: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. METHODS: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. RESULTS: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016). CONCLUSION: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/97221
url https://hdl.handle.net/2445/97221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0081276
PLoS One, 2013, vol. 8, num. 11, p. e81276
http://dx.doi.org/10.1371/journal.pone.0081276
dc.rights.none.fl_str_mv cc-by (c) Monyarch, G. et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Monyarch, G. et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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