Genomic and functional conservation of lncRNAs: lessons from flies

Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the...

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Authors: Camilleri Robles, Carlos, Amador, Raziel, Klein, Cecilia C., Guigó Serra, Roderic, Corominas, Montserrat (Corominas Guiu), Ruiz Romero, Marina
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/186441
Online Access:https://hdl.handle.net/2445/186441
Access Level:Open access
Keyword:Drosòfila melanogaster
Mosques
Drosophila melanogaster
Flies
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repository_id_str
spelling Genomic and functional conservation of lncRNAs: lessons from fliesCamilleri Robles, CarlosAmador, RazielKlein, Cecilia C.Guigó Serra, RodericCorominas, Montserrat (Corominas Guiu)Ruiz Romero, MarinaDrosòfila melanogasterMosquesDrosophila melanogasterFliesOver the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological processes, including development and disease, most of their functions and mechanisms of action remain unknown. Poor conservation of the DNA sequences encoding for these transcripts makes the identification of lncRNAs orthologues among different species very challenging, especially between evolutionarily distant species such as flies and humans or mice. However, the functions of lncRNAs are unexpectedly preserved among different species supporting the idea that conservation occurs beyond DNA sequences and reinforcing the potential of characterising lncRNAs in animal models. In this review, we describe the features and roles of lncRNAs in the fruit fly Drosophila melanogaster, focusing on genomic and functional comparisons with human and mouse lncRNAs. We also discuss the current state of advances and limitations in the study of lncRNA conservation and future perspectives.Springer Verlag2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/186441Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1007/s00335-021-09939-4Mammalian Genome, 2022, vol. 33, num. 2, p. 328-342https://doi.org/10.1007/s00335-021-09939-4cc-by (c) Camilleri‑Robles, Carlos et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1864412026-05-27T06:46:51Z
dc.title.none.fl_str_mv Genomic and functional conservation of lncRNAs: lessons from flies
title Genomic and functional conservation of lncRNAs: lessons from flies
spellingShingle Genomic and functional conservation of lncRNAs: lessons from flies
Camilleri Robles, Carlos
Drosòfila melanogaster
Mosques
Drosophila melanogaster
Flies
title_short Genomic and functional conservation of lncRNAs: lessons from flies
title_full Genomic and functional conservation of lncRNAs: lessons from flies
title_fullStr Genomic and functional conservation of lncRNAs: lessons from flies
title_full_unstemmed Genomic and functional conservation of lncRNAs: lessons from flies
title_sort Genomic and functional conservation of lncRNAs: lessons from flies
dc.creator.none.fl_str_mv Camilleri Robles, Carlos
Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas, Montserrat (Corominas Guiu)
Ruiz Romero, Marina
author Camilleri Robles, Carlos
author_facet Camilleri Robles, Carlos
Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas, Montserrat (Corominas Guiu)
Ruiz Romero, Marina
author_role author
author2 Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas, Montserrat (Corominas Guiu)
Ruiz Romero, Marina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Drosòfila melanogaster
Mosques
Drosophila melanogaster
Flies
topic Drosòfila melanogaster
Mosques
Drosophila melanogaster
Flies
description Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological processes, including development and disease, most of their functions and mechanisms of action remain unknown. Poor conservation of the DNA sequences encoding for these transcripts makes the identification of lncRNAs orthologues among different species very challenging, especially between evolutionarily distant species such as flies and humans or mice. However, the functions of lncRNAs are unexpectedly preserved among different species supporting the idea that conservation occurs beyond DNA sequences and reinforcing the potential of characterising lncRNAs in animal models. In this review, we describe the features and roles of lncRNAs in the fruit fly Drosophila melanogaster, focusing on genomic and functional comparisons with human and mouse lncRNAs. We also discuss the current state of advances and limitations in the study of lncRNA conservation and future perspectives.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186441
url https://hdl.handle.net/2445/186441
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00335-021-09939-4
Mammalian Genome, 2022, vol. 33, num. 2, p. 328-342
https://doi.org/10.1007/s00335-021-09939-4
dc.rights.none.fl_str_mv cc-by (c) Camilleri‑Robles, Carlos et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Camilleri‑Robles, Carlos et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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